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Table 2 Baseline characteristics of the participants

From: Integrated bioinformatics analysis elucidates granulosa cell whole-transcriptome landscape of PCOS in China

Characteristic

Control (n = 66)

PCOS (n = 64)

P value

Age (years)

30.45 ± 3.71

30.03 ± 3.68

0.515

BMI (kg/m2)

21.76 ± 3.10

22.87 ± 3.10

0.044

Duration of infertility (years)

2.57 ± 2.14

3.83 ± 2.51

0.004

Antral follicle count

13.31 ± 4.88

19.70 ± 6.86

0.000

Laboratory tests

 Ratio of LH to FSH

0.98 ± 0.76

1.47 ± 0.92

0.001

 LH (IU/L)

6.39 ± 6.71

8.63 ± 5.14

0.036

 FSH (IU/L)

6.27 ± 1.45

6.07 ± 1.71

0.472

 Estradiol (pmol/L)

88.40 ± 47.65

92.51 ± 51.42

0.640

 TT (nmol/L)

0.69 ± 0.34

1.34 ± 0.66

0.000

 P (nmol/L)

1.41 ± 1.46

1.11 ± 1.88

0.310

 PRL (ng/ml)

24.25 ± 8.56

19.54 ± 17.05

0.165

 AMH (ng/mL)

4.36 ± 2.18

8.37 ± 4.82

0.000

 Triglyceride (mmol/ L)

1.05 ± 0.47

1.54 ± 1.09

0.001

 Total cholesterol (mmol/L)

4.11 ± 0.61

4.92 ± 2.16

0.004

 HDL-C (mmol/L)

1.41 ± 0.25

1.32 ± 0.30

0.071

 LDL-C (mmol/L)

2.37 ± 0.48

2.58 ± 0.61

0.028

 Fasting glucose (mmol/L)

4.61 ± 0.75

4.87 ± 0.57

0.108

 Fasting insulin (µU/ mL)

7.33 ± 3.49

9.98 ± 6.78

0.430

 HOMA-IR

1.61 ± 0.65

2.31 ± 1.44

0.001

 Duration of gonadotropin stimulation (d)

9.91 ± 1.73

11.23 ± 2.61

0.001

 Total dose of gonadotropin (IU)

2077.27 ± 664.73

2085.12 ± 813.93

0.952

Type of fertilization— no. (%)

  

0.923

 With IVF

33 (50.00%)

32 (50.00%)

 

 With ICSI

23 (34.85%)

23 (35.94%)

 

 With mixed IVF and ICSI

10 (15.15%)

9 (14.06%)

 

 No. of oocytes retrieved

13.32 ± 5.63

17.78 ± 9.21

0.001

 No. of MII oocytes

10.97 ± 5.29

15.05 ± 8.49

0.001

 Rate of MII oocytes

0.84 ± 0.21

0.86 ± 0.19

0.712

 No. of 2 PN fertilized

7.91 ± 4.71

9.58 ± 6.47

0.095

 2PN fertilization rate

0.72 ± 0.22

0.62 ± 0.25

0.015

 No. of day 3 good-quality embryos

3.98 ± 2.23

4.47 ± 2.94

0.292

 Rate of day 3 good-quality embryos

0.57 ± 0.25

0.52 ± 0.27

0.236

  1. Data are presented as the mean ± standard deviation, or number (percentage) of cases
  2. BMI Body mass index, LH Luteinizing hormone, FSH Follicle-stimulating hormone, TT Total testosterone, AMH Anti-mullerian hormone, P Progesterone, PRL Prolactin, HDL High-density lipoprotein, LDL Low-density lipoprotein, HOMA-IR Homeostatic model assessment of insulin resistance, IVF In vitro fertilization, ICSI Intracytoplasmic sperm injection, MII Mature oocytes, 2PN fertilized oocytes with two primary pronucleus
  3. P-value from analysis of variance or independent t-test for continuous variables, and Chi-square test or Fisher’s exact test for categorical variables. p < 0.05 was considered statistically significant