Table 2 Overview of the role of LINC00174 in cancer
Cancer | Expression | Functions | Role | Mechanism | Reference |
|---|---|---|---|---|---|
NSCLC | Downregulated | Overexpression of LINC00174 inhibited NSCLC cell proliferation and migration, and induced apoptosis | Tumor suppressor | LINC00174/miR-31-5p/LATS2 axis | [47] |
CRC | Upregulated | Overexpression of LINC00174 promoted CRC cell viability, proliferation, migration, invasion and EMT | Oncogene | LINC00174/miR-3127-5p/E2F7 axis | [34] |
KIRC | Upregulated | Overexpression of LINC00174 promoted KIRC cell viability, proliferation, migration and invasion | Oncogene | LINC00174/miR-612/FOXM1 axis | [36] |
HCC | Upregulated | Overexpression of LINC00174 accelerated proliferation and metastasis of HCC cells while reduced apoptosis | Oncogene | LINC00174/miR-320/S100A10 axis | [37] |
BCa | Upregulated | Knockdown of LINC00174 attenuated proliferative and migratory abilities in BCa cells. | Oncogene | LINC00174/miR-1827 | [38] |
Glioma | Upregulated | Knockdown of LINC00174 significantly suppressed GBM cells proliferation | Oncogene | - | [39] |
OS | Upregulated | Knockdown of LINC00174 suppressed OS Cell Proliferation, Migration, Invasion and OS Tumor Growth | Oncogene | LINC00174/miR-378a-3p/SSH2 and TGF-β/SMAD pathway | [43] |
TETs | Upregulated | Knockdown of LINC00174 reduced cell proliferation, migration, and lipid droplets accumulation in TET cells | Oncogene | LINC00174/miR-145-5p/SCD5 axis | [44] |
Glioma | Upregulated | Knockdown of LINC00174 could remarkably prevent cell proliferation and promote cell apoptosis in both glioma cells and Temozolomide-resistant glioma cells | Oncogene | LINC00174/miR-138-5p/SOX9 axis | [40] |
Glioma | Upregulated | Knockdown of LINC00174 increased BTB permeability and reduced the expression of the tight junction-related proteins ZO-1, occludin, and claudin-5 | Oncogene | LINC00174/miR-138-5p (miR-150-5p)/FOSL2 feedback loop | [41] |
Glioma | Upregulated | Knockdown of LINC00174 inhibited cell proliferation, migration, invasion and glycolysis of glioma cells | Oncogene | LINC00174/miR-152-3p/SLC2A1 axis | [42] |
CRC | Upregulated | Knockdown of LINC00174 could repress CRC cell growth | Oncogene | LINC00174/miR-1910-3p/TAZ axis | [35] |
LUSC | Upregulated | Knockdown of LINC00174 could repress LUSC cells proliferation, migration, and invasion while promoting cell apoptosis | Oncogene | LINC00174/miR-185-5p/NFIX axis | [45] |
LC | Upregulated | Knockdown of LINC00174 could repress LC cells proliferation, migration, invasion and angiogenesis while promoting cell apoptosis | Oncogene | LINC00174/miR-584-3p/RPS24 axis | [46] |