From: Fertility preservation after gonadotoxic treatments for cancer and autoimmune diseases
Characteristics | Â | |
---|---|---|
Number of participants (n) | 43 | Â |
Number of cycles (n) | 67 | Â |
Age (years) | 32 | (29–37) |
AFC | 7 | (4–13) |
Basal FSH (IU/L) | 6.1 | (5.7–9.9) |
AMH (ng/ml) | 1.48 | (0.29–3.22) |
Disease type [n (%)]a | ||
 Haematological cancers | 6 | (14.0) |
 Breast cancer | 22 | (51.2) |
 Gynecological cancers | 3 | (7.0) |
 Sarcoma | 2 | (4.7) |
 Other cancers | 6 | (14.0) |
 Systemic autoimmune diseases | 4 | (9.3) |
Gonadotroxic treatment [n (%)]a | ||
 Before fertility preservation | 38 | (88.4) |
 After fertility preservation | 5 | (11.6) |
Stimulation start timing/ stimulation phase [n (%)]b | ||
 Normal (Day 1–4) | 31 | (46.3) |
 Random (Follicular phase, Luteal phase) | 31 | (46.3) |
 DuoStim | 5 | (7.5) |
LH suppression regimen [n (%)]b | ||
 GnRH antagonist | 27 | (40.3) |
 PPOS | 17 | (25.4) |
 Others | 23 | (34.3) |
Gonadotropin | ||
 Starting dose of Gonadotropin (IU) | 225 | (150–300) |
 Duration of Gonadotropin use (days) | 10 | (8–12) |
 Total dosage of Gonadotropin use (IU) | 2100 | (1350–2700) |
Triggar [n (%)]b | ||
 hCG or recombinant hCG | 64 | (95.5) |
 GnRHa | 1 | (1.5) |
 Dual triggar | 2 | (3.0) |
 Serum estradiol on trigger day (pmol/L) | 1281.5 | (749.3–2044.3) |
Outcome of oocyte retrieval | ||
 Number of oocyte retrieved (n) | 7 | (3–12) |
 Number of MII oocytes retrieved (n) | 6 | (2–11) |
 Number of MI oocytes retrieved (n) | 0 | (0–1) |
 Number of GV oocytes retrieved (n) | 0 | (0–1) |
 Mature oocyte rate (%)c | 91.7 | (76.3–100) |
Method for fertilisation [n (%)]b | ||
 Conventional insemination | 6 | (9.0) |
 Intracytoplasmic sperm injection | 14 | (20.9) |
 Split | 6 | (9.0) |
 None | 41 | (61.2) |
Embryological outcome | ||
 Fertilisation rate (%)d | 75.0 | (57.1–100) |
 Cleavage developmental rate (%)e | 85.7 | (62.5–100) |
 Blastocyst developmental rate (%)f | 87.5 | (57.1–100) |
Vitrified stage [n (%)]a | ||
 Oocyte | 27 | (62.8) |
 Blastocyst | 16 | (37.2) |