Fig. 1

Identification of differentially expressed pyroptosis-related genes (DE-PRGs) in ovarian cancer (OV). (A) The flowchart of the research. (B) The heatmap of differential gene expression, among which the top 50 up-regulated and the top 50 down-regulated genes were listed. Different colors represent the different trend of gene expression between normal tissues and OV tissues. (C) The volcano plot showed the differentially expressed genes (DEGs) between normal tissues and OV tissues. The up-regulated and down-regulated DEGs were respectively highlighted in red and blue. (D) The Venn plot of the DE-PRGs. (E) The Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis of the 106 DE-PRGs (up). The hallmark pathway from mSigDB enrichment analysis of the 106 DE-PRGs (bottom). Here, the top 20 clusters were shown, while the size of the circles represents gene ratio and the color scale represents the p-value. (F) The protein-protein interaction (PPI) network plot of the 106 DE-PRGs (left), among which 13 hub genes with significant associations were defined (right)