Fig. 7From: Progestin and adipoQ receptor 7 (PAQR7) mediate the anti-apoptotic effect of P4 on human granulosa cells and its deficiency reduces ovarian function in female miceThe protein levels of PAQR7 in DOR patients and mice. (A) The protein levels of PAQR7 were examined in the granulosa cells (GCs) isolated from female suffering from patients diagnosed with diminished ovarian reserve (DOR, n = 8) and the Control group (n = 11). (B) Construction of the mouse model for decreased ovarian reserve (DOR). Assessment of ovarian follicles via HE-staining assays in DOR mice ovaries. Scale bars represent 200 μm. (C) The numbers of follicles/ovary were reduced in DOR mice. (D) The ovarian index in DOR mice. (E, F) The protein level of PAQR7 in the ovary of DOR mice (n = 3) and the control group (n = 3). *P < 0.05, ***P < 0.001, compared with the control mice by the student t-testBack to article page