Table 1 GO analysis of DEGs according to the expression of ALKBH5 in ovarian cancer
From: ALKBH5 modulates macrophages polarization in tumor microenvironment of ovarian cancer
Ontology | ID | Description | Count | P-value | Fold enrichment |
|---|---|---|---|---|---|
BP | GO: 0006954 | Inflammatory response | 14 | 0.0000296 | 4.201085608 |
BP | GO:0006955 | Immune response | 13 | 0.000604 | 3.288925209 |
BP | GO:0006629 | Lipid metabolic process | 7 | 0.007533531 | 4.069801683 |
BP | GO:0061844 | Antimicrobial humoral immune response mediated by antimicrobial peptide | 5 | 0.012541582 | 5.547305046 |
BP | GO:0032355 | Response to estradiol | 5 | 0.013740931 | 5.398716518 |
BP | GO:0050852 | T cell receptor signaling pathway | 6 | 0.018869267 | 3.901008065 |
BP | GO:0045893 | Positive regulation of transcription, DNA-templated | 12 | 0.022040078 | 2.175674663 |
BP | GO:0071805 | Potassium ion transmembrane transport | 5 | 0.022460029 | 4.651201923 |
BP | GO:0008285 | Negative regulation of cell proliferation | 9 | 0.035365282 | 2.381578228 |
BP | GO:0007165 | Signal transduction | 17 | 0.039221453 | 1.707501038 |
BP | GO:0007399 | Nervous system development | 8 | 0.040573389 | 2.50634715 |
CC | GO:0005576 | Extracellular region | 34 | 0.000291 | 1.916231801 |
CC | GO:0009986 | Cell surface | 15 | 0.000699 | 2.891282943 |
CC | GO:0005887 | Integral component of plasma membrane | 23 | 0.004477562 | 1.896484463 |
CC | GO:0005615 | Extracellular space | 27 | 0.008560599 | 1.685749584 |
CC | GO:0070062 | Extracellular exosome | 30 | 0.009312576 | 1.614527868 |
CC | GO:0016021 | Integral component of membrane | 58 | 0.024020882 | 1.281279272 |
CC | GO:0005886 | Plasma membrane | 53 | 0.035827021 | 1.275180742 |
MF | GO:0005125 | Cytokine activity | 9 | 0.000259 | 5.421373556 |
MF | GO:0005515 | Protein binding | 124 | 0.009391396 | 1.133723536 |
MF | GO:0008889 | Glycerophosphodiester phosphodiesterase activity | 2 | 0.04267721 | 45.7804878 |
MF | GO:0008083 | Growth factor activity | 5 | 0.056972199 | 3.447325889 |
MF | GO:0016504 | Peptidase activator activity | 2 | 0.091506587 | 20.80931264 |
MF | GO:0005507 | Copper ion binding | 3 | 0.09307753 | 5.819553535 |