Table 5 Gene ontology and pathway analysis of hypermethylated genes using DAVID tool. 6Â A) KEGG pathway, 6B) Biological process (BP), 6C) Cellular component (CC) and 6D) Molecular function (MF)
Category | Term | Count | P-Value |
|---|---|---|---|
KEGG_PATHWAY | Focal adhesion | 10 | 2.20E-03 |
Regulation of actin cytoskeleton | 10 | 4.90E-03 | |
Calcium signaling pathway | 10 | 9.20E-03 | |
MAPK signaling pathway | 11 | 9.90E-03 | |
Ras signaling pathway | 9 | 1.80E-02 | |
HIF-1 signaling pathway | 6 | 1.90E-02 | |
ErbB signaling pathway | 5 | 3.10E-02 | |
GOTERM_BP_DIRECT | cell morphogenesis | 8 | 2.40E-04 |
positive regulation of protein phosphorylation | 10 | 2.10E-03 | |
protein autophosphorylation | 9 | 2.60E-03 | |
synapse assembly | 6 | 2.70E-03 | |
eye development | 5 | 2.80E-03 | |
modulation of synaptic transmission | 6 | 5.00E-03 | |
protein targeting to lysosome | 4 | 5.80E-03 | |
signal transduction | 29 | 5.80E-03 | |
response to thyroid hormone | 3 | 5.80E-03 | |
brain development | 10 | 7.90E-03 | |
homophilic cell adhesion via plasma membrane adhesion molecules | 8 | 8.30E-03 | |
establishment of cell polarity | 4 | 1.20E-02 | |
peptidyl-tyrosine phosphorylation | 5 | 1.40E-02 | |
central nervous system development | 7 | 1.40E-02 | |
detection of calcium ion | 3 | 1.40E-02 | |
animal organ development | 4 | 1.40E-02 | |
positive regulation of epithelial cell proliferation | 5 | 1.50E-02 | |
response to nicotine | 4 | 1.50E-02 | |
actin filament organization | 7 | 1.60E-02 | |
endocytosis | 8 | 2.40E-02 | |
positive regulation of bone resorption | 3 | 2.50E-02 | |
epidermis development | 5 | 2.60E-02 | |
neuromuscular synaptic transmission | 3 | 3.10E-02 | |
transmembrane receptor protein tyrosine kinase signaling pathway | 6 | 3.30E-02 | |
negative regulation of cell migration | 7 | 3.60E-02 | |
animal organ morphogenesis | 6 | 3.60E-02 | |
glial cell differentiation | 3 | 3.90E-02 | |
fibroblast growth factor receptor signaling pathway | 4 | 4.10E-02 | |
multicellular organism development | 6 | 4.20E-02 | |
regulation of cytoskeleton organization | 3 | 4.20E-02 | |
positive regulation of osteoclast differentiation | 3 | 4.20E-02 | |
cell-cell adhesion | 7 | 4.40E-02 | |
regulation of cell shape | 6 | 4.80E-02 | |
protein dephosphorylation | 6 | 4.90E-02 | |
GOTERM_CC_DIRECT | synapse | 20 | 8.80E-05 |
cytoplasm | 96 | 3.10E-03 | |
neuron projection | 13 | 3.40E-03 | |
axon terminus | 5 | 7.30E-03 | |
axon | 12 | 7.90E-03 | |
adherens junction | 8 | 9.80E-03 | |
plasma membrane | 88 | 9.90E-03 | |
sarcolemma | 6 | 1.30E-02 | |
neuronal cell body | 11 | 2.30E-02 | |
cytosol | 89 | 2.40E-02 | |
presynaptic membrane | 6 | 2.60E-02 | |
integral component of postsynaptic density membrane | 4 | 2.90E-02 | |
postsynaptic density membrane | 5 | 3.80E-02 | |
extrinsic component of postsynaptic membrane | 2 | 3.90E-02 | |
cell-cell junction | 7 | 4.00E-02 | |
cell projection | 7 | 4.00E-02 | |
glutamatergic synapse | 11 | 4.40E-02 | |
GOTERM_MF_DIRECT | actin binding | 13 | 2.50E-03 |
cadherin binding | 12 | 4.20E-03 | |
protein phosphatase binding | 6 | 7.60E-03 | |
heterocyclic compound binding | 3 | 7.70E-03 | |
alpha-catenin binding | 3 | 9.30E-03 | |
dystroglycan binding | 3 | 9.30E-03 | |
protein kinase activity | 12 | 1.50E-02 | |
SH2 domain binding | 4 | 1.80E-02 | |
small GTPase binding | 10 | 1.90E-02 | |
protein kinase activator activity | 4 | 1.90E-02 | |
clathrin binding | 4 | 2.30E-02 | |
calmodulin binding | 8 | 2.30E-02 | |
phospholipid scramblase activity | 3 | 2.40E-02 | |
phosphatidylinositol-3-phosphate binding | 4 | 2.40E-02 | |
SH3 domain binding | 6 | 2.90E-02 | |
3’,5’-cyclic-nucleotide phosphodiesterase activity | 3 | 3.20E-02 | |
protein tyrosine kinase binding | 4 | 3.30E-02 | |
enzyme binding | 11 | 3.50E-02 | |
protein serine/threonine/tyrosine kinase activity | 12 | 3.90E-02 | |
structural molecule activity | 7 | 4.90E-02 |