Table 6 Details of top six hypermethylated genes obtained from MeDIP-sequencing
Hypermethylated Genes | Gene name | Feature | log2FoldChange | p-value | Status in ovarian cancer |
|---|---|---|---|---|---|
POLR3B | RNA polymerase III subunit B | Promoter 1k | 0.66 | 0.006106 | Not reported in ovarian cancer |
PLXND1 | Plexin D | Promoter 1k | 0.69 | 0.000595 | Only 1 study reported mentioning regulation of Epithelial-Mesenchymal transition by PLXND1 |
GIGYF2 | Grb 10-interacting GYF protein 2 | Promoter 1k | 0.33 | 0.033441 | Not reported in ovarian cancer |
STK4 | Serine/Threonine kinase 4 | Promoter 3k | 0.5 | 0.019861 | Reported as downregulated in OC |
CRKL | CRK-like proto oncogene | Promoter 3k | 0.78 | 0.003422 | Two studies were reported demonstrating the regulation of EMT through ERK signalling pathwway. Another study reported its overexpression. |
BMP2 | Bone morphogenetic protein 2 | Promoter 3k | 0.5 | 0.023133 | Few studies were reported. One of them had shown a downregulated expression. |