Figure 2
From: Safe and targeted anticancer therapy for ovarian cancer using a novel class of curcumin analogs
The dual functionality of DAP-F(p)-NOH or DAP-CF3(p)-NOH compounds. The reductive environment of the cancer cells shifts the equilibrium balance, such that less antioxidant cytoprotection is afforded to cancer cells versus normal cells. The –NOH (N-hydroxy-pyrroline) moiety undergoes conversion to and exists in equilibrium with the nitroxide (>NO) form (shown in the circle).