Fig. 4
From: DNA damage repair in ovarian cancer: unlocking the heterogeneity
Eukaryotic mismatch repair mechanism. DNA mismatches are recognised by the mismatch recognition factor MutSα, which then prompts binding and DNA stabilisation by the MLH1-PMS2 heterodimer (MutLα). The PCNA and RFA clamp loader are able to load on at a nearby ‘nick’. MutSα activated exonuclease 1 (Exo1) excise the mismatch in a 5′ to 3′ direction and the excised fragment of DNA is removed by the DNA polymerase δ holoenzyme. DNA polymerase δ refills the DNA gap and it is ligated by DNA ligase I