Table 3 NER components and response to platinum therapy in ovarian cancer

ERCC1

Forms heterodimer with ERCC4 to form XPF, which binds DNA with nuclease activity

SNP C8092A, which affects mRNA stability associated with reduced tumour size and more differentiation [96].

In vitro cell line experiments found high ERCC1 expression correlated to platinum resistance due to upregulated NER [97]

XPA

Binds and stabilises damaged DNA

Paradoxically XPA expression associated with better overall survival in women with metastatic ovarian cancer and chemotherapy response [98]

XPB

A transcription factor that can also aid unwinding of DNA at sites of damage

Five fold higher mRNA expression in platinum resistant ovarian cancer cell lines than non resistant cells [89].

XPG

Endonuclease that catalyses 3′ incision

No statistically significant effect of XPG polymorphisms [94]

CSB

ATP dependent helicase that enables DNA repair

Six times higher mRNA expression in platinum resistant ovarian cancer cells [98]