Skip to main content

Advertisement

  • Correction
  • Open Access

Correction to: Nanog interaction with the androgen receptor signaling axis induce ovarian cancer stem cell regulation: studies based on the CRISPR/Cas9 system

Contributed equally
Journal of Ovarian Research201912:11

https://doi.org/10.1186/s13048-019-0487-3

  • Published:

The original article was published in Journal of Ovarian Research 2018 11:36

Correction to: J Ovarian Res (2018) 11:36

https://doi.org/10.1186/s13048-018-0403-2

The original article [1] contains errors in Figs. 6 and 8. The corrected figures can be shown ahead.
Fig. 6
Fig. 6

Migratory tendency of GFP (+)/GFP (−) cells when treated with different hormone drugs. a and b) The number of migratory cells increased in the DHT groups of the A2780 + 20 and SKOV3 + 5 GFP (+)/GFP (−) cell lines. c and d) Notably, when treated with DHT, the number of GFP (+) migratory cells increased markedly compared with DMSO or DHT + ASC-J9; e and f) The number of migratory in A2780 + 20 and SKOV3 + 5 Nanog GFP (+) cells were also higher than that of the Nanog GFP (−) cells. For analysis, the cells number in four fields was calculated at 40× magnification. Bar: 100 μM. DHT: 10 nM, and ASC-J9: 5 μM. **P < 0.01; ***P < 0.001

Fig. 8
Fig. 8

AR signaling axis enhances the stemness characteristics of ovarian cancer cells. a) Sphere formation assays of the monoclonal GFP (+)/GFP (−) cells of the SKPV3 + 5 and A2780 + 20 cell lines. The sphere formation abilities of the GFP (+) cell lines were significantly stronger than those of the GFP (−) cell lines. Bar: 200 μM. b) Colony formation assays of the monoclonal GFP (+)/GFP (−) cells of the SKPV3 + 5 and A2780 + 20 cell lines. The clonal efficiency of the GFP (+) cells was higher than that of the GFP (−) cells. Bar: 200 μM. c and d) Androgen or inhibitor treatment in SKPV3 + 5 and A2780 + 20 GFP (+) cells. Sphere and colony formation were enhanced when DHT was added, while ASC-J9 decreased this effect. DMSO was used as the vehicle control. DHT: 10 nM, and ASC-J9: 5 μM; Bar: 100 μM. *P < 0.05, **P < 0.01, and ***P < 0.001

Notes

Declarations

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

Authors’ Affiliations

(1)
Department of Obstetrics & Gynecology, Southwest Hospital, Third Military Medical University, Chongqing, 400038, China
(2)
Bjrigham Young University, ID 272 Rigby Hall, Rexburg, 83460–4500, USA
(3)
Department of Obstetrics & Gynaecology Faculty of Medicine, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong, China

Reference

  1. Ling K, Jiang L, Liang S, et al. Nanog interaction with the androgen receptor signaling axis induce ovarian cancer stem cell regulation: studies based on the CRISPR/Cas9 system. J Ovarian Res. 2018;11:36 https://doi.org/10.1186/s13048-018-0403-2.View ArticleGoogle Scholar

Copyright

© The Author(s). 2019

Advertisement