Table 1 The baseline characteristics of the patients and the ovarian stimulation characteristics and embryological outcomes of the patients with different serum E2/P ratios on OPU + 7
Characteristic | Total | E2/P ratios on OPU + 7 (pg/ng) | |||
|---|---|---|---|---|---|
Low (1.3—15.7) | Middle (15.7—28.8) | High (28.8—487.2) | P-value | ||
No. of cycles | 2257 | 752 | 751 | 754 | |
Female Age (years) | 29.6 ± 3.5 | 29.8 ± 3.6 | 29.5 ± 3.5 | 29.4 ± 3.4 | 0.159 |
BMI (kg/m2) | 23.2 ± 3.7 | 22.4 ± 3.5 | 23.0 ± 3.6 | 24.1 ± 4.0 | < 0.001 |
AMH (ng/ml) | 6.4 ± 3.6 | 5.9 ± 3.3 | 6.5 ± 3.5 | 6.7 ± 3.8 | < 0.001 |
AFC | 18.2 ± 7.1 | 16.8 ± 6.5 | 18.1 ± 7.0 | 19.5 ± 7.5 | < 0.001 |
Infertility duration (years) | 3.3 ± 2.4 | 3.5 ± 2.3 | 3.3 ± 2.4 | 3.2 ± 2.3 | 0.133 |
Infertility type | 0.800 | ||||
Primary | 1213 (53.7%) | 397 (52.8%) | 409 (54.5%) | 407 (54.0%) | |
Secondary | 1044 (46.3%) | 355 (47.2%) | 342 (45.5%) | 347 (46.0%) | |
Infertility factors | < 0.001 | ||||
Pelvic and tubal factors | 1483 (65.7%) | 484 (64.4%) | 511 (68.0%) | 488 (64.7%) | |
Endometriosis | 90 (4.0%) | 46 (6.1%) | 28 (3.7%) | 16 (2.1%) | |
Male factor | 470 (20.8%) | 142 (18.9%) | 151 (20.1%) | 177 (23.5%) | |
Unexplained | 214 (9.5%) | 80 (10.6%) | 61 (8.1%) | 73 (9.7%) | |
Fertilization method | 0.930 | ||||
IVF | 1879 (83.3%) | 626 (83.2%) | 628 (83.6%) | 625 (82.9%) | |
ICSI | 378 (16.7%) | 126 (16.8%) | 123 (16.4%) | 129 (17.1%) | |
Dosage of Gn (IU) | 2303.1 ± 823.4 | 2298.2 ± 812.0 | 2234.5 ± 798.1 | 2376.2 ± 853.7 | 0.004 |
Duration of Gn (days) | 11.8 ± 1.7 | 11.9 ± 1.8 | 11.8 ± 1.7 | 11.7 ± 1.7 | 0.040 |
Endometrial thickness on hCG day (mm) | 11.7 ± 2.6 | 11.5 ± 2.6 | 11.7 ± 2.7 | 11.7 ± 2.6 | 0.139 |
Moderate or severe OHSS rate | 55 (2.4%) | 22 (2.9%) | 22 (2.9%) | 11 (1.5%) | 0.103 |
No. of oocytes retrieved | 11.1 ± 2.4 | 10.8 ± 2.2 | 11.1 ± 2.5 | 11.3 ± 2.5 | < 0.001 |
No. of mature oocytes | 10.4 ± 2.3 | 10.1 ± 2.1 | 10.4 ± 2.3 | 10.6 ± 2.4 | < 0.001 |
Fertilization rate (2PN) (%) | 89.3 ± 10.0 | 88.6 ± 10.1 | 89.7 ± 10.0 | 89.7 ± 9.9 | 0.048 |
Cleavage rate (%) | 98.9 ± 4.1 | 98.2 ± 5.1 | 99.1 ± 3.6 | 99.3 ± 3.3 | < 0.001 |
No. of embryos obtained | 4.8 ± 1.0 | 4.7 ± 1.1 | 4.8 ± 1.1 | 4.7 ± 1.0 | 0.751 |
good-quality embryo rate (%) | 80.8 ± 17.0 | 79.9 ± 16.1 | 80.3 ± 17.5 | 82.2 ± 17.2 | 0.020 |
Blastocyst formation rate (%) | 86.4 ± 19.6 | 83.1 ± 21.1 | 86.3 ± 19.8 | 89.7 ± 17.3 | < 0.001 |
No. of transferred embryos, n (%) | 0.026 | ||||
1 | 1345 (59.6%) | 475 (63.2%) | 445 (59.3%) | 425 (56.4%) | |
2 | 912 (40.4%) | 277 (36.8%) | 306 (40.7%) | 329 (43.6%) | |
Implantation rate | 65.4 ± 44.3 | 61.6 ± 45.5 | 63.8 ± 44.6 | 70.7 ± 42.2 | < 0.001 |
Trigger dosage | < 0.001 | ||||
rhCG 250 µg | 678 (30.0%) | 241 (32.0%) | 231 (30.8%) | 206 (27.3%) | |
rhCG 250 µg + uhCG 1000 IU | 195 (8.6%) | 80 (10.6%) | 73 (9.7%) | 42 (5.6%) | |
rhCG 250 µg + uhCG 2000 IU | 1384 (61.3%) | 431 (57.3%) | 447 (59.5%) | 506 (67.1%) | |
Luteal support | < 0.001 | ||||
C | 224 (9.9%) | 93 (12.4%) | 73 (9.7%) | 58 (7.7%) | |
C + D | 268 (11.9%) | 68 (9.0%) | 97 (12.9%) | 103 (13.7%) | |
C + D + P | 1243 (55.1%) | 403 (53.6%) | 457 (60.9%) | 383 (50.8%) | |
C + D + P + F | 522 (23.1%) | 188 (25.0%) | 124 (16.5%) | 210 (27.9%) | |