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  1. Cancer stem cells (CSCs) are believed to be ‘seed cell’ in cancer recurrence and metastasis. MicroRNAs (miRNAs) can play an important role in the progression of primary tumor towards metastasis by regulating t...

    Authors: Dengyu Chen, Yunxia Zhang, Jing Wang, Junsong Chen, Cuiping Yang, Kai Cai, Xiaoying Wang, Fangfang Shi and Jun Dou

    Citation: Journal of Ovarian Research 2013 6:50

    Content type: Research

    Published on:

  2. Surgery is the cornerstone for clinical management of patients with borderline ovarian tumors (BOT). As these patients have an excellent overall prognosis, perioperative morbidity is the critical point for dec...

    Authors: Fabian Trillsch, Jan David Ruetzel, Uwe Herwig, Ulrike Doerste, Linn Woelber, Donata Grimm, Matthias Choschzick, Fritz Jaenicke and Sven Mahner

    Citation: Journal of Ovarian Research 2013 6:48

    Content type: Research

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  3. Primary non-Hodgkin’s lymphoma of the ovary is a rare occurrence. An ovarian involvement by non-Hodgkin lymphoma (NHL) may include one of the four subtypes of lymphoma: diffuse large B-cell lymphoma, Burkitt’s...

    Authors: Paola Bianchi, Francesco Torcia, Marta Vitali, Giuliana Cozza, Marco Matteoli and Valentina Giovanale

    Citation: Journal of Ovarian Research 2013 6:46

    Content type: Case report

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  4. VEGF may play a role in the pathogenesis of cancer disease, for example in cell growth, proliferation and angiogenesis. In this study, we investigated plasma levels of this cytokine in comparison to plasma lev...

    Authors: Sławomir Ławicki, Grażyna Ewa Będkowska, Ewa Gacuta-Szumarska and Maciej Szmitkowski

    Citation: Journal of Ovarian Research 2013 6:45

    Content type: Research

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  5. Endometriosis is frequently associated with high levels of CA125. This marker is therefore not useful for discriminating ovarian endometrioma from ovarian malignancy. The aim of this study was to establish a p...

    Authors: Emanuela Anastasi, Teresa Granato, Renato Falzarano, Paola Storelli, Adele Ticino, Luigi Frati, Pierluigi Benedetti Panici and Maria Grazia Porpora

    Citation: Journal of Ovarian Research 2013 6:44

    Content type: Research

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  6. Leydig cell tumours represent more than 75% of all testosterone-secreting ovarian masses. These benign tumours are frequently occult or very small, but cause dramatic virilization. Chronic hyperandrogenism can...

    Authors: Giovanna Saraceno, Valeria Barresi, Francesco Trimarchi and Salvatore Cannavo

    Citation: Journal of Ovarian Research 2013 6:43

    Content type: Case report

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  7. Approximately one third of women diagnosed with ovarian cancer is 70 years or older. Information on the treatment reality of these elderly patients is limited.

    Authors: Fabian Trillsch, Linn Woelber, Christine Eulenburg, Ioana Braicu, Sandrina Lambrechts, Radoslav Chekerov, Els van Nieuwenhuysen, Paul Speiser, Alain Zeimet, Dan Cacsire Castillo-Tong, Nicole Concin, Robert Zeillinger, Ignace Vergote, Sven Mahner and Jalid Sehouli

    Citation: Journal of Ovarian Research 2013 6:42

    Content type: Research

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  8. Malignant tumors are the single most common cause of death and the mortality rate of ovarian cancer is the highest among gynecological disorders. The excision of benign tumors is generally followed by complete...

    Authors: Chi-Chang Chang, Chao-Ming Hung, Yun-Ru Yang, Mon-Juan Lee and Yi-Chiang Hsu

    Citation: Journal of Ovarian Research 2013 6:41

    Content type: Research

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  9. Our work has been carried out in the context of the therapeutic failure in ovarian carcinoma, which remains the leading cause of death by gynecologic malignancy. In these tumours, recurrence and subsequent acq...

    Authors: Julie Tomasina, Aurélie Malzert-Freon, Florence Giffard, Emilie Brotin, Marie-Hélène Louis, Edwige Abeilard, Sylvain Rault, Pascal Gauduchon and Laurent Poulain

    Citation: Journal of Ovarian Research 2013 6:38

    Content type: Brief communication

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  10. Vitamin D deficiency and vitamin D receptor (VDR) gene polymorphism, FokI, is reported to increase the risk of many cancers. Role of vitamin D and its receptor polymorphisms in ovarian cancer has not been clearly...

    Authors: Sudhesna Mohapatra, Alpana Saxena, Gauri Gandhi, Bidhan Chandra Koner and Prakash Chandra Ray

    Citation: Journal of Ovarian Research 2013 6:37

    Content type: Research

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  11. The polycystic ovary syndrome (PCOS) is a complex and heterogeneous endocrine condition characterized by hyperandrogenism, hyperinsulinemia, insulin resistance and chronic anovulation. Regulation and interacti...

    Authors: Md Munir Hossain, Mingju Cao, Qi Wang, Ji Young Kim, Karl Schellander, Dawit Tesfaye and Benjamin K Tsang

    Citation: Journal of Ovarian Research 2013 6:36

    Content type: Research

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  12. A diagnosis of advanced ovarian cancer is the beginning of a long and arduous journey for a patient. Worldwide, approximately half of the individuals undergoing therapy for advanced cancer will succumb to the ...

    Authors: Kellie S Rath, Georgia A McCann, David E Cohn, Brian K Rivera, Periannan Kuppusamy and Karuppaiyah Selvendiran

    Citation: Journal of Ovarian Research 2013 6:35

    Content type: Review

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  13. Metastatic neoplasms to the ovary often cause diagnostic problems, in particular those large ovarian masses mimicking primary tumors. Most of these tumors arise from digestive system or breast, while 37-year-o...

    Authors: Nunzia Simona Losito, Cono Scaffa, Monica Cantile, Gerardo Botti, Raffaele Costanzo, Angela Manna, Renato Franco and Stefano Greggi

    Citation: Journal of Ovarian Research 2013 6:34

    Content type: Case report

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  14. Currently, cryopreservation of oocytes, embryos and ovarian tissue is considered the basis of fertility preservation programs for women with cancer and other diseases who are rendered sterile by gonadotoxic dr...

    Authors: Justo Callejo, Cristina Salvador, Santiago González-Nuñez, Laura Almeida, Luciano Rodriguez, Laura Marqués, Ana Valls and José Maria Lailla

    Citation: Journal of Ovarian Research 2013 6:33

    Content type: Case report

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  15. Polycystic Ovary Syndrome (PCOS) is defined by two out of the following three criteria being met: oligo- or anovulation, hyperandrogenism, and polycystic ovaries. Affected women are often obese and insulin res...

    Authors: E Leonie AF van Houten, Joop SE Laven, Yvonne V Louwers, Anke McLuskey, Axel PN Themmen and Jenny A Visser

    Citation: Journal of Ovarian Research 2013 6:32

    Content type: Brief communication

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  16. The capacity of nadir CA-125 levels to predict the prognosis of epithelial ovarian cancer remains controversial. This study aimed to explore whether the nadir CA-125 serum levels could predict the durations of...

    Authors: Xia Xu, Yan Wang, Fang Wang, Lizhou Jia, Yiqin Zhou, Fei Deng, Junwei Qu, Bifang Zhou, Aifeng Meng, Bole Fu, Xiaoxiang Chen, Zhiying Qian and Jinhua Wang

    Citation: Journal of Ovarian Research 2013 6:31

    Content type: Research

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  17. Oocyte in vitro maturation (IVM) and cryopreservation at the time of routine ovarian tissue freezing may be offered to cancer patients as an additional option for fertility preservation. This study aimed to in...

    Authors: Patrick Imesch, David Scheiner, Min Xie, Daniel Fink, Erwin Macas, Raghvendra Dubey and Bruno Imthurn

    Citation: Journal of Ovarian Research 2013 6:30

    Content type: Research

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  18. Evaluate and compare the utility of serum folate receptor alpha (FRA) and megakaryocyte potentiating factor (MPF) determinations relative to serum CA125, mesothelin (MSLN) and HE4 for the diagnosis of epitheli...

    Authors: Daniel J O’Shannessy, Elizabeth B Somers, Leslie M Palmer, Robert P Thiel, Pankaj Oberoi, Ryan Heath and Lisa Marcucci

    Citation: Journal of Ovarian Research 2013 6:29

    Content type: Research

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  19. This study aimed to investigate an unusual case of immature ovarian teratoma with onset of mature glial cells implanted on the contralateral ovary, a challenge in the diagnosis of the second ovarian tumor. We ...

    Authors: Ancuta Gheorghisan-Galateanu, Dana Cristina Terzea, Mara Carsote and Catalina Poiana

    Citation: Journal of Ovarian Research 2013 6:28

    Content type: Case report

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  20. Leiomyosarcoma of the rectum is a very rare mesenchymal tumor. Because of its rarity, its diagnosis, treatment, and pathology often present challenges to the clinician. The characteristics of this tumor, such ...

    Authors: Yung-Taek Ouh, Jin Hwa Hong, Kyung-Jin Min, Kyeong-A So and Jae Kwan Lee

    Citation: Journal of Ovarian Research 2013 6:27

    Content type: Case report

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  21. High-grade serous ovarian cancers are a distinct histological subtype of ovarian cancer often characterised by a dysfunctional BRCA/Fanconi anaemia (BRCA/FA) pathway, which is critical to the homologous recomb...

    Authors: Thomas Mikeska, Kathryn Alsop, Gillian Mitchell, David DL Bowtell and Alexander Dobrovic

    Citation: Journal of Ovarian Research 2013 6:26

    Content type: Brief communication

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  22. Platinum drugs, including cisplatin, are a frontline therapeutic in ovarian cancer treatment and acquired resistance to these agents is a major contributor to ovarian cancer morbidity and mortality. In this st...

    Authors: Matthew J Schultz, Amanda F Swindall, John W Wright, Elizabeth S Sztul, Charles N Landen and Susan L Bellis

    Citation: Journal of Ovarian Research 2013 6:25

    Content type: Research

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  23. It has already been found that very small embyronic-like stem cells (VSELs) are present in adult human tissues and organs. The aim of this study was to find if there exists any similar population of cells in c...

    Authors: Irma Virant-Klun, Martin Stimpfel, Branko Cvjeticanin, Eda Vrtacnik-Bokal and Thomas Skutella

    Citation: Journal of Ovarian Research 2013 6:24

    Content type: Research

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  24. Although agonistic autoantibodies against type-1 angiotensin-II receptor (AT1-AA) are frequently detected in women with preeclampsia, the clinical significance of AT1-AA in association with epithelial ovarian can...

    Authors: Li Song, Su-Li Zhang, Ke-Hua Bai, Jie Yang, Hai-Yan Xiong, Xiao Li, Teng Liu and Hui-Rong Liu

    Citation: Journal of Ovarian Research 2013 6:22

    Content type: Research

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  25. Ovarian cancer has the highest mortality rate of all gynaecologic cancers. Faced with poor prognoses, stressful treatment effects and a high likelihood of recurrence, survivors must confront significant physic...

    Authors: Shalini H Moonsammy, Crissa L Guglietti, Daniel Santa Mina, Sarah Ferguson, Jennifer L Kuk, Sara Urowitz, David Wiljer and Paul Ritvo

    Citation: Journal of Ovarian Research 2013 6:21

    Content type: Research

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  26. Cryopreserved ovarian cortical tissue acts as a source of primordial follicles (PF) which can either be auto-transplanted or cultured in vitro to obtain mature oocytes. This offers a good opportunity to attain bi...

    Authors: Seema Parte, Deepa Bhartiya, Dhananjay D Manjramkar, Anahita Chauhan and Amita Joshi

    Citation: Journal of Ovarian Research 2013 6:20

    Content type: Research

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  27. Epithelial ovarian cancer (EOC) is the most lethal gynecological cancer. Several hospitals throughout the region provide primary treatment for these patients and it is well know that treatment quality is corre...

    Authors: Vincenzo Dario Mandato, Martino Abrate, Pierandrea De Iaco, Debora Pirillo, Gino Ciarlini, Maurizio Leoni, Giuseppe Comerci, Alessandro Ventura, Bruno Lenzi, Andrea Amadori, Federica Rosati, Ruby Martinello, Rossana De Palma, Chiara Ventura, Laura Maria Beatrice Belotti, Debora Formisano…

    Citation: Journal of Ovarian Research 2013 6:19

    Content type: Research

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  28. Ovarian carcinoma is the leading cause of cancer death worldwide among gynecological malignancies, and the majority of cases are related with recurrence and chemoresistance. Cancer stem cells (CSCs) are believ...

    Authors: Young Tae Park, Ju-yeon Jeong, Mi-jung Lee, Kwang-il Kim, Tae-Heon Kim, Young-do Kwon, Chan Lee, Ok Jun Kim and Hee-Jung An

    Citation: Journal of Ovarian Research 2013 6:18

    Content type: Research

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  29. There is no information in the literature on the impact of changes in quality of life (QoL) scores on prognosis in ovarian cancer. We investigated whether changes in QoL during treatment could predict survival...

    Authors: Digant Gupta, Donald P Braun, Edgar D Staren and Maurie Markman

    Citation: Journal of Ovarian Research 2013 6:17

    Content type: Research

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  30. Successful egg cryopreservation has many potential benefits to a variety of patients. However, a superior standard protocol describing all aspects of oocyte cryopreservation has not yet been identified. Oocyte...

    Authors: Cassie T Wang, Lifeng Liang, Craig Witz, Dan Williams, Jason Griffith, Josh Skorupski, Ghassan Haddad, Jimmy Gill and Weihua Wang

    Citation: Journal of Ovarian Research 2013 6:15

    Content type: Research

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  31. There is no consensus regarding the management of ovarian cancer patients, who have shown complete clinical response (CCR) to primary therapy and have rising cancer antigen CA-125 levels but have no symptoms o...

    Authors: Fang Wang, Yanfen Ye, Xia Xu, Xuehui Zhou, Jinhua Wang and Xiaoxiang Chen

    Citation: Journal of Ovarian Research 2013 6:14

    Content type: Research

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  32. The massive edema of ovary, with or without fibromatosis, is a rare tumor-like entity characterized by an increase in volume of one or both ovaries for accumulation of edema fluid in the stroma that separates ...

    Authors: Rossella De Cecio, Monica Cantile, Nicola Fortunato, Annarosaria De Chiara, Nunzia Simona Losito, Renato Franco and Gerardo Botti

    Citation: Journal of Ovarian Research 2013 6:13

    Content type: Case report

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  33. The ovarian surface epithelium responds to cytokines and hormonal cues to initiate proliferation and migration following ovulation. Although insulin and IGF are potent proliferative factors for the ovarian sur...

    Authors: Shelby M King, Dimple A Modi, Sharon L Eddie and Joanna E Burdette

    Citation: Journal of Ovarian Research 2013 6:12

    Content type: Research

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  34. The FSH starting dose is usually chosen according to women’s age, anamnesis, clinical criteria and markers of ovarian reserve. Currently used markers include antral follicle count (AFC), which is considered to...

    Authors: Antonio La Marca, Valentina Grisendi, Simone Giulini, Cindy Argento, Alessandra Tirelli, Giulia Dondi, Enrico Papaleo and Annibale Volpe

    Citation: Journal of Ovarian Research 2013 6:11

    Content type: Research

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  35. Ovarian cancer (OC) is the sixth most common cancer in women. Currently, carboplatin/paclitaxel ± bevacizumab is the cornerstone of front-line treatment. Conversely, the therapeutic options for recurrent or pr...

    Authors: Nicoletta Staropoli, Domenico Ciliberto, Cirino Botta, Lucia Fiorillo, Simona Gualtieri, Angela Salvino, Pierfrancesco Tassone and Pierosandro Tagliaferri

    Citation: Journal of Ovarian Research 2013 6:10

    Content type: Research

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  36. Intraperitoneal (i.p.) models that accurately mimic the feature behavior of human ovarian cancer are required to investigate the pathology and therapeutics of the disease. However, established i.p. models whic...

    Authors: Jianjun Zhang, Xinlian Chen, Gang Shi, Xiaoyan Xie, Hongqian Liu, Xuemei Zhang, Yi Lai, Yan Zuo, Zhong Chen, Shanling Liu and He Wang

    Citation: Journal of Ovarian Research 2013 6:9

    Content type: Research

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  37. Cell lines are very useful for clinical and basic research. Thus far, only 11 reports have documented the characteristics of ovarian endometrioid adenocarcinoma cell lines in the literature. Due to the scarcit...

    Authors: Takashi Yamada, Takayoshi Kanda, Hiroshi Mori, Kaname Shimokawa, Mitsuo Kagawa and Yuro Shibayama

    Citation: Journal of Ovarian Research 2013 6:8

    Content type: Research

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  38. Since ovarian cancer is associated with high frequency of p53 mutation, the availability of p 53 r eactivation and i nduction of m assive a poptosis (PRIMA-1) offers a possible new therapeutic strategy for overco...

    Authors: Noriko Kobayashi, Mohammadreza Abedini, Noriaki Sakuragi and Benjamin K Tsang

    Citation: Journal of Ovarian Research 2013 6:7

    Content type: Research

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  39. Anti-Her-2 treatment is successfully administered to Her-2 overexpressing breast cancer patients and significantly implicates upon their survival. Building on these promising results, anti-Her-2 treatment prot...

    Authors: Sabine Heublein, Thomas Vrekoussis, Doris Mayr, Klaus Friese, Miriam Lenhard, Udo Jeschke and Darius Dian

    Citation: Journal of Ovarian Research 2013 6:6

    Content type: Brief communication

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  40. Epithelial ovarian cancer is one of the leading causes of gynaecological cancer morbidity and mortality in women. Early stage ovarian cancer is usually asymptomatic, therefore, is often first diagnosed when it...

    Authors: Ratana Lim, Martha Lappas, Clyde Riley, Niels Borregaard, Holger J Moller, Nuzhat Ahmed and Gregory E Rice

    Citation: Journal of Ovarian Research 2013 6:5

    Content type: Research

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  41. Under-carboxylated osteocalcin (ucOC), the precursor substrate of bone biomarker OC is a potent regulator of energy metabolism by promoting insulin production and adiponectin synthesis and decreasing fat store...

    Authors: Carmen E Pepene

    Citation: Journal of Ovarian Research 2013 6:4

    Content type: Research

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  42. Chronological age and oocyte yield are independent determinants of live birth in assisted conception. Anti-Müllerian hormone (AMH) is strongly associated with oocyte yield after controlled ovarian stimulation....

    Authors: Amani Khader, Suzanne M Lloyd, Alex McConnachie, Richard Fleming, Valentina Grisendi, Antonio La Marca and Scott M Nelson

    Citation: Journal of Ovarian Research 2013 6:3

    Content type: Research

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  43. There is a clinical need for routinely available genomic biomarker testing in newly diagnosed ovarian cancer. In the current study we performed molecular cytogenetics using a validated array based comparative ...

    Authors: Shelly Gunn, Xavier Reveles, Korrie Weldon, Andres Barrera, Mariam Ishaque, Dale Taylor, Chris McCaskill, Jaeweon Kim, Rashmi Shah, Mansoor Mohammed, Todd Barry, Brianne Kaiser, Amita Patnaik and Anthony Tolcher

    Citation: Journal of Ovarian Research 2013 6:2

    Content type: Research

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  44. The assessment of the embryo quality is crucial to maintain an high pregnancy rate and to reduce the risk of multiple pregnancy. The evaluation of the pronuclear and nucleolar characteristics of human zygote h...

    Authors: Alessia Nicoli, Francesco Capodanno, Ilaria Rondini, Barbara Valli, Maria Teresa Villani, Daria Morini, Leonardo De Pascalis, Stefano Palomba and Giovanni Battista La Sala

    Citation: Journal of Ovarian Research 2013 6:1

    Content type: Review

    Published on:

  45. Epithelial Ovarian Cancer (EOC) is the second most common gynaecological cancer and accounts for more deaths than all gynaecological cancers combined. Despite extensive research, progress has been slow in unde...

    Authors: Thumuluru Kavitha Madhuri, Anil Tailor, Ben Haagsma, Helen Coley and Simon Butler-Manuel

    Citation: Journal of Ovarian Research 2012 5:46

    Content type: Review

    Published on:

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