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  1. Content type: Research

    The anti-tumor effects of S-allylcysteine (SAC), a water-soluble garlic derivative, on human ovarian cancer cells have been previous studied in vitro and in vivo models but the precise epigenetic molecular mec...

    Authors: Yasi Xu, Dan Su, Lucheng Zhu, Shirong Zhang, Shenglin Ma, Kan Wu, Qiang Yuan and Nengming Lin

    Citation: Journal of Ovarian Research 2018 11:39

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  2. Content type: Research

    Myo-inositol (MI), successfully used in polycystic ovary syndrome (PCOS), was administered with α-LA to exploit its action of favouring the passage of other molecules through biological barriers, and also cons...

    Authors: Mario Montanino Oliva, Giovanna Buonomo, Marco Calcagno and Vittorio Unfer

    Citation: Journal of Ovarian Research 2018 11:38

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  3. Content type: Research

    The use of long protocol during controlled ovarian stimulation for assisted reproduction attracts high dosage of gonadotropins. High dose of gonadotropins can be detrimental to oocyte development, which affect...

    Authors: Humphrey Ochin, Xiang Ma, Lin Wang, Xuan Li, Jie Song, Yan Meng, Jiandong Shen, Yu-Gui Cui and Jiayin Liu

    Citation: Journal of Ovarian Research 2018 11:37

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  4. Content type: Research

    Ovarian cancer stem cells (OCSCs) contribute to the poor prognosis of ovarian cancer. Involvement of the androgen receptor (AR) in the malignant behaviors of other tumors has been reported. However, whether AR...

    Authors: Kaijian Ling, Lupin Jiang, Shi Liang, Joseph Kwong, Leiyan Yang, Yudi Li, PingYin, Qingchun Deng and Zhiqing Liang

    Citation: Journal of Ovarian Research 2018 11:36

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    The Correction to this article has been published in Journal of Ovarian Research 2019 12:11

  5. Content type: Research

    Fertility preservation by whole ovary cryopreservation and transplantation (WOCP&TP) with vascular anastomosis requires successful cryopreservation. In this study, we investigated the possibility of restoring ...

    Authors: Yan Ding, Jia-liang Shao, Jun-wei Li, Ying Zhang, Kai-hua Hong, Ke-qin Hua and Xiang Wang

    Citation: Journal of Ovarian Research 2018 11:35

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  6. Content type: Research

    The granulosa cells are indispensable for follicular development and its function is orchestrated by several genes, which in turn posttranscriptionally regulated by microRNAs (miRNA). In our previous study, th...

    Authors: Hari Om Pande, Dawit Tesfaye, Michael Hoelker, Samuel Gebremedhn, Eva Held, Christiane Neuhoff, Ernst Tholen, Karl Schellander and Dessie Salilew Wondim

    Citation: Journal of Ovarian Research 2018 11:34

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  7. Content type: Research

    In recent years, cancer rates have been rising among reproductive-age women. Thus, chemotherapy exposure has become an important cause of premature ovarian failure (POF). There has been growing interest regard...

    Authors: Rauf Melekoglu, Osman Ciftci, Sevil Eraslan, Asli Cetin and Nese Basak

    Citation: Journal of Ovarian Research 2018 11:33

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  8. Content type: Research

    KLK10 exon 3 hypermethylation correlated to tumor-specific lack of KLK10 expression in cancer cell lines and primary tumors. In the present study we investigate the possible role of KLK10 exon 3 methylation in ov...

    Authors: Mustafa A. El Sherbini, Amal A. Mansour, Maha M. Sallam, Emtiaz A. Shaban, Zeinab A. Shehab ElDin and Amr H. El-Shalakany

    Citation: Journal of Ovarian Research 2018 11:32

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  9. Content type: Research

    B-cell-specific Moloney murine leukemia virus integration site 1 (BMI1) might be an appropriate biomarker in the management of epithelial ovarian cancer (EOC). However, the biological role of BMI1 and its rele...

    Authors: Qianying Zhao, Qiuhong Qian, Dongyan Cao, Jiaxin Yang, Ting Gui and Keng Shen

    Citation: Journal of Ovarian Research 2018 11:31

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  10. Content type: Research

    Synchronous endometrial disorders have been poorly studied in women with endometrioid borderline ovarian tumors (EBOT). The aims of this study were to investigate the risk of endometrial disorders among women ...

    Authors: Shuang-zheng Jia, Jun-ji Zhang, Jun-jun Yang, Yang Xiang, Zhiyong Liang and Jin-hua Leng

    Citation: Journal of Ovarian Research 2018 11:30

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  11. Content type: Research

    Obesity has been linked to several types of cancers including ovarian cancer. Retinol binding protein 4 (RBP4) is an adipokine that drives the development of hyperinsulinemia and type II diabetes in obesity pa...

    Authors: Yanyan Wang, Yilin Wang and Zhenyu Zhang

    Citation: Journal of Ovarian Research 2018 11:29

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  12. Content type: Research

    In recent years the question of the lack of transparency in clinical research has been debated by clinicians, researchers, citizens and their representatives, authors and publishers. This is particularly impor...

    Authors: Anna Roberto, Silvia Radrezza and Paola Mosconi

    Citation: Journal of Ovarian Research 2018 11:28

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  13. Content type: Research

    Ovarian cancer is the leading gynecologic cancer diagnosed in North America and because related symptoms are not disease specific, this often leads to late detection, an advanced disease state, and the need fo...

    Authors: Taryne Chong, Amila Sarac, Cindy Q. Yao, Linda Liao, Nicola Lyttle, Paul C. Boutros, John M. S. Bartlett and Melanie Spears

    Citation: Journal of Ovarian Research 2018 11:27

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  14. Content type: Research

    PCOS is a leading endocrinopathy of young women instigating androgens elevation, insulin resistance, obesity, cardiometabolic and menstrual complications. The study investigated the effects of quercetin in a l...

    Authors: Sarwat Jahan, Abira Abid, Sidra Khalid, Tayyaba Afsar, Qurat-Ul-Ain, Ghazala Shaheen, Ali Almajwal and Suhail Razak

    Citation: Journal of Ovarian Research 2018 11:26

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  15. Content type: Research

    Hyperandrogenism and insulin resistance may be related to the etiology of PCOS. Zucker fa/fa rats with polycystic ovary are obese, have insulin resistance without diabetes mellitus or hyperandrogenism and can ...

    Authors: Miyuki Morishita, Toshiaki Endo, Tsuyoshi Baba, Yoshika Kuno, Keiko Ikeda, Tamotsu Kiya, Hiroyuki Honnma and Tsuyoshi Saito

    Citation: Journal of Ovarian Research 2018 11:24

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  16. Content type: Research

    Highly Individualized Egg Retrieval (HIER), defined as age-specific early oocyte retrieval (ER), has been demonstrated to avoid premature luteinization in women ≥43. We here investigated whether HIER also appl...

    Authors: Yan-Guang Wu, David H. Barad, Vitaly A. Kushnir, Qi Wang, Lin Zhang, Sarah K. Darmon, David F. Albertini and Norbert Gleicher

    Citation: Journal of Ovarian Research 2018 11:23

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  17. Content type: Research

    The recurrence, metastasis and poor prognosis are important characteristics of ovarian carcinoma (OC), which are associated with exfoliation of cells from the primary tumor and colonization of the cells in pel...

    Authors: Ji Pang, Pengcheng Jiang, Ying Wang, Lu Jiang, Hai Qian, Yan Tao, Ruxia Shi, Jizong Gao, Yongchang Chen and Yan Wu

    Citation: Journal of Ovarian Research 2018 11:22

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  18. Content type: Research

    The purpose of this retrospective study was to determine the prognosis of non-serous epithelial ovarian cancer (EOC) patients with exclusively retroperitoneal lymph node (LN) metastases, and to compare the pro...

    Authors: Hanifi Sahin, Mehmet Mutlu Meydanli, Mustafa Erkan Sari, Ibrahim Yalcin, Gonca Çoban, Nazlı Topfedaisi Ozkan, Zeliha Firat Cuylan, Baki Erdem, Kemal Gungorduk, Özgür Akbayir, Murat Dede, Mustafa Coşkun Salman, Tayfun Güngör and Ali Ayhan

    Citation: Journal of Ovarian Research 2018 11:21

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  19. Content type: Research

    Extracellular vesicles (EVs) are considered as a new class of resources for potential biomarkers. We analyzed expression of specific mRNA and miRNA in EVs derived from ovarian cancer ascites and the ideal cont...

    Authors: Cindy M. Yamamoto, Melanie L. Oakes, Taku Murakami, Michael G. Muto, Ross S. Berkowitz and Shu-Wing Ng

    Citation: Journal of Ovarian Research 2018 11:20

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  20. Content type: Research

    Metformin influences insulin receptor signaling, which might interfere with the proliferation of ovarian follicular structures and steroidogenesis. We hypothesize that reductions in glucose and insulin levels ...

    Authors: Roberta Rassi Mahamed, Carla Cristina Maganhin, Gisela Rodrigues Silva Sasso, Manuel de Jesus Simões, Maria Candida Pinheiro Baracat, Edmund Chada Baracat and José Maria Soares- Jr

    Citation: Journal of Ovarian Research 2018 11:18

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  21. Content type: Research

    High cyclooxygenase (COX)-2 expression in ovarian tumors has been associated with poor prognosis, but the role of COX-1 expression and its relation to survival is less clear. Here, we evaluated COX expression ...

    Authors: Alicia Beeghly-Fadiel, Andrew J. Wilson, Spencer Keene, Meral El Ramahi, Shu Xu, Lawrence J. Marnett, Oluwole Fadare, Marta A. Crispens and Dineo Khabele

    Citation: Journal of Ovarian Research 2018 11:17

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  22. Content type: Research

    Ovarian cancer is a leading cause of the death from gynecologic malignancies. Hypoxia is closely related to the malignant growth of cells. However, the molecular mechanism of hypoxia-regulated ovarian cancer c...

    Authors: Ke Zhang, Xiangjun Kong, Guangde Feng, Wei Xiang, Long Chen, Fang Yang, Chunyu Cao, Yifei Ding, Hang Chen, Mingxing Chu, Pingqing Wang and Baoyun Zhang

    Citation: Journal of Ovarian Research 2018 11:16

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  23. Content type: Case report

    Pelvic masses are a common gynecologic problem, and majority of them are diagnosed as ovarian tumors finally. Sometimes, it is hard to distinguish the origin of these pelvic masses. The following case is a sol...

    Authors: Wei-Ting Chao, Chia-Hao Liu, Yi-Jen Chen, Hua-Hsi Wu, Chi-Mu Chuang and Peng-Hui Wang

    Citation: Journal of Ovarian Research 2018 11:14

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  24. Content type: Review

    Over these years, more and more sex cord-stromal tumors have been reported. Granulosa cell tumor (GCT) is a rare tumor in ovaries, accounts for 2% to 5% of ovarian cancers. The main different feature of GCTs f...

    Authors: Jiaheng Li, Riqiang Bao, Shiwei Peng and Chunping Zhang

    Citation: Journal of Ovarian Research 2018 11:13

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  25. Content type: Research

    The ST6Gal-I sialyltransferase is upregulated in numerous cancers, and high expression of this enzyme correlates with poor patient prognosis in various malignancies, including ovarian cancer. Through its sialy...

    Authors: Colleen M. Britain, Andrew T. Holdbrooks, Joshua C. Anderson, Christopher D. Willey and Susan L. Bellis

    Citation: Journal of Ovarian Research 2018 11:12

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  26. Content type: Case report

    Struma ovarii is a rare ovarian neoplasm that often appears malignant on conventional imaging. Pseudo-Meigs’ syndrome with ascites, pleural effusion, and elevated serum CA 125 levels is much rarer and leads to...

    Authors: Sayaka Fujiwara, Hideaki Tsuyoshi, Toshiya Nishimura, Nozomu Takahashi and Yoshio Yoshida

    Citation: Journal of Ovarian Research 2018 11:11

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  27. Content type: Research

    Cancer is widely believed to result from chronic inflammation, and red cell distribution width (RDW) and mean platelet volume (MPV) are considered as inflammatory markers for cancer. We investigated the values...

    Authors: Yuan-yuan Qin, Yang-yang Wu, Xiao-ying Xian, Jin-qiu Qin, Zhan-feng Lai, Lin Liao and Fa-quan Lin

    Citation: Journal of Ovarian Research 2018 11:10

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  28. Content type: Research

    Toll-like receptors (TLRs) are transmembrane proteins expressed on the surface of ovarian cancer (OC) and immune cells. Identifying the specific roles of the TLR-mediated signaling pathways in OC cells is impo...

    Authors: Luiz Gustavo de Almeida Chuffa, Grazielle de Moura Ferreira, Luiz Antonio Lupi, Iseu da Silva Nunes and Wagner José Fávaro

    Citation: Journal of Ovarian Research 2018 11:8

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  29. Content type: Research

    Serous borderline tumor (SBT) of the micropapillary type (SBT-MP) became one of the major pathological SBT diagnoses in addition to typical SBT, and was also defined as “non-invasive” low-gradeserous carcinoma...

    Authors: Go Nakai, Takashi Yamada, Kazuhiro Yamamoto, Yoshinobu Hirose, Masahide Ohmichi and Yoshifumi Narumi

    Citation: Journal of Ovarian Research 2018 11:7

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  30. Content type: Research

    The polycystic ovary syndrome (PCOS) is a common metabolic and endocrine disorder with pathological mechanisms remain unclear. The following study investigates the ovarian hyperfibrosis forming via transformin...

    Authors: Daojuan Wang, Wenqing Wang, Qiao Liang, Xuan He, Yanjie Xia, Shanmei Shen, Hongwei Wang, Qian Gao and Yong Wang

    Citation: Journal of Ovarian Research 2018 11:6

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  31. Content type: Research

    To evaluate the performance of computed tomography (CT) as a diagnostic aid to differentiate between ruptured ovarian corpus luteal cyst (ROCLC) and ruptured ectopic pregnancy with hemorrhage (REPWH).

    Authors: Xiaohong Liu, Litao Song, Jian Wang, Qin Liu, Yingna Liu and Xin Zhang

    Citation: Journal of Ovarian Research 2018 11:5

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  32. Content type: Research

    Autotransplantation of cryopreserved ovarian cortex can be associated with a risk of cancer cell reseeding. This issue could be eliminated by grafting isolated preantral follicles. Collagenase NB6 is an enzyme...

    Authors: Elodie Mouloungui, Tristan Zver, Christophe Roux and Clotilde Amiot

    Citation: Journal of Ovarian Research 2018 11:4

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  33. Content type: Research

    Stem cells in the ovary comprise of two distinct populations including very small embryonic-like stem cells (VSELs) and slightly bigger progenitors termed ovarian stem cells (OSCs). They are lodged in ovary su...

    Authors: Hiren Patel, Deepa Bhartiya and Seema Parte

    Citation: Journal of Ovarian Research 2018 11:3

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  34. Content type: Research

    Improvements in oocyte cryopreservation techniques and establishment of cryopreserved donor oocyte banks have led to improved access to and lower cost of donor oocytes, upending the traditional practice of fre...

    Authors: Vitaly A. Kushnir, Sarah K. Darmon, David H. Barad and Norbert Gleicher

    Citation: Journal of Ovarian Research 2018 11:2

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  35. Content type: Research

    MMP and TIMP play an important role in the degradation of extracellular matrix components which are essential for tumor growth, invasion and metastasis. Aim of this research was to assess MMP3 and TIMP3 as pro...

    Authors: Aneta Cymbaluk-Płoska, Anita Chudecka-Głaz, Ewa Pius-Sadowska, Bogusław Machaliński, Janusz Menkiszak and Agnieszka Sompolska-Rzechuła

    Citation: Journal of Ovarian Research 2018 11:1

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  36. Content type: Research

    Food restriction during pregnancy can influence the health of the offspring during the adulthood. The aim of the present study was to examine the effect of maternal food restriction (MFR) on the reproductive p...

    Authors: Abdel Halim Harrath, Abdulkarem Alrezaki, Lamjed Mansour, Saleh H. Alwasel and Stefano Palomba

    Citation: Journal of Ovarian Research 2017 10:77

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  37. Content type: Research

    TEK signaling plays a very important role in folliculogenesis. It activates Ras/ERK/MYC, PI3K/AKT/mTORC1 and ovarian steroidogenesis activation pathways. These are the main pathways for cell growth, differenti...

    Authors: Abolfazl Bahrami, Seyed Reza Miraie-Ashtiani, Mostafa Sadeghi, Ali Najafi and Reza Ranjbar

    Citation: Journal of Ovarian Research 2017 10:76

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  38. Content type: Review

    Limited understanding of ovarian cancer (OC) genome portrait has hindered the therapeutic advances. The serial monitoring of tumor genotypes is becoming increasingly attainable with circulating cell-free DNA (...

    Authors: Xianliang Cheng, Lei Zhang, Yajuan Chen and Chen Qing

    Citation: Journal of Ovarian Research 2017 10:75

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  39. Content type: Research

    Supplementation of bovine oocyte-cumulus complexes during in vitro maturation (IVM) with 1 μM of docosahexaenoic acid (DHA), C22:6 n-3 polyunsaturated fatty acid, was reported to improve in vitro embryo develo...

    Authors: Sebastien Elis, Mouhamad Oseikria, Anais Vitorino Carvalho, Priscila Silvana Bertevello, Emilie Corbin, Ana-Paula Teixeira-Gomes, Jérôme Lecardonnel, Catherine Archilla, Véronique Duranthon, Valérie Labas and Svetlana Uzbekova

    Citation: Journal of Ovarian Research 2017 10:74

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  40. Content type: Review

    Exosomes are nanoparticles(40-100 nm) secreted by most cells in the body, which can be isolated from several types of extracellular fluids. It has been shown that exosomes play a key role in intercellular comm...

    Authors: Lin Cheng, Shuying Wu, Kun Zhang, Yun’an Qing and Tianmin Xu

    Citation: Journal of Ovarian Research 2017 10:73

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  41. Content type: Research

    In order to validate if the test result of the Chemotherapy Resistance Test (CTR-Test) is able to predict the resistances or sensitivities of tumors in ovarian cancer patients to drugs, the CTR-Test result and...

    Authors: Frank Christian Kischkel, Carina Meyer, Julia Eich, Mani Nassir, Monika Mentze, Ioana Braicu, Annette Kopp-Schneider and Jalid Sehouli

    Citation: Journal of Ovarian Research 2017 10:72

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  42. Content type: Research

    Ovarian tissue cryopreservation followed by transplantation after cancer remission is the most commonly applied fertility restoration approach in very young girls and women who require immediate cancer therapy...

    Authors: Maria Costanza Chiti, Marie-Madeleine Dolmans, Maria Hobeika, Alice Cernogoraz, Jacques Donnez and Christiani Andrade Amorim

    Citation: Journal of Ovarian Research 2017 10:71

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  43. Content type: Research

    There is no consensus on the exact parameters that define the LH surge for natural cycle frozen-thawed embryo transfers (NC-FET). Accurately determining the LH surge would affect the timing, and subsequently t...

    Authors: Mohamad Irani, Alex Robles, Vinay Gunnala, David Reichman and Zev Rosenwaks

    Citation: Journal of Ovarian Research 2017 10:70

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  44. Content type: Research

    Metastasis is the major cause of morbidity and mortality in patients with epithelial ovarian cancer (EOC), however the mechanisms that underline this process are poorly understood. Collagen triple helix repeat...

    Authors: Biying Guo, Huan Yan, Luying Li, Kemin Yin, Fang Ji and Shu Zhang

    Citation: Journal of Ovarian Research 2017 10:69

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  45. Content type: Research

    Luteinizing hormone (LH) regulation of the ligand, natriuretic peptide precursor type C, and its receptor, natriuretic peptide receptor 2 (NPR2), is critical for oocyte maturation; however, the mechanism is no...

    Authors: Wenchao Sun, Chang Liu, Ying Feng, Guangchao Zhuo, Wenjing Zhou, Xiaoyang Fei and Zhifen Zhang

    Citation: Journal of Ovarian Research 2017 10:68

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  46. Content type: Research

    Clinico-pathological characteristics and possible prognostic factors among women with epithelial ovarian carcinoma (EOC) with or without concurrent endometriosis were explored.

    Authors: Tong Ren, Shu Wang, Jian Sun, Ji-Min Qu, Yang Xiang, Keng Shen and Jing He Lang

    Citation: Journal of Ovarian Research 2017 10:67

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