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Olaparib, a poly ADP-ribose polymerase (PARP) inhibitor, has proven to be effective and safe as maintenance therapy and multiline therapy in ovarian cancer, especially in patients with BRCA mutations. ... efficac...
Ovarian cancer (OC) is one of the most aggressive women cancers with increasing incidence and mortality rates worldwide. ... demonstrated play an important roles in a many cancers, the detailed function and mecha...
Both BRCA1 and angiotensin II type 1 receptor (AGTR1) play a critical role in ovarian cancer progression. However, the crosstalk between BRCA1 and AGTR1 signaling pathways remains largely unknown.
The HOX genes are a family of homeodomain-containing transcription factors that determine cellular identity during development. Here we review a number of recent studies showing that HOX genes are strongly expres...
There is no information in the literature on the impact of changes in quality of life (QoL) scores on prognosis in ovarian cancer. We investigated whether changes in QoL during treatment could predict survival in...
About 5–10% of all ovarian cancer cases show familial clustering, and some 15–25% of familial ovarian cancer cases are mediated by high-penetrance mutations...BRCA1 and BRCA2...genes. Only few other genes have be...
In this study, we tested the hypothesis that single nucleotide polymorphisms (SNPs) of differentiation-associated human gene icb-1 (C1orf38) may be associated with ovarian cancer susceptibility. For this purpose,...
Fertility preservation using ovarian tissue cryopreservation (OTC) in patients with certain diseases, especially those needing chemo- or radiotherapy, is becoming routine in various Western countries. Our hospita...
Glutathione peroxidase 3 (GPX3) is a selenocysteine-containing antioxidant enzyme that reacts with hydrogen peroxide and soluble fatty acid hydroperoxides, thereby helping to maintain redox balance within cells. ...
Pegylated liposomal doxorubicin (PLD) is a nano-doxorubicin anticancer agent. It was used as early as 2014 to treat ovarian and breast cancer, multiple myeloma and Kaposi's sarcoma. The 2018 National Comprehensiv...
Karyopherin α-2 (KPNA2) is a member of karyopherin family, which is proved to be responsible for the import or export of cargo proteins. Studies have determined that KPNA2 is associated with the development and p...
Ovarian cancer is one of the most common gynecological ... fairly high. However, the pathogenesis of ovarian cancer is not clear. The present study aimed ... expressed genes and signaling pathways associated with...
Drug resistance and recurrence are main contributors to the poor prognosis of ovarian cancer. Cisplatin is a platinum compound which is ... the treatment of various solid tumors including ovarian cancer. Up to no...
MicroRNAs (miRNAs) are non-coding, single-stranded small RNAs that regulate gene expression negatively, which is involved in fundamental cellular processes. In this study, we investigated the role of miR-490-3P i...
The Erratum to this article has been published in Journal of Ovarian Research 2015 8:79
Endometrioid carcinoma of the ovary is one of the most types of epithelial ovarian cancer associated to endometrioisis. Endometrioid tumors as well ... ) in the most common subtypes of ovarian cancer cells compar...
To detect the expression of Growth factor binding protein 2 associated binding protein 2 (Gab2) and CT10 regulator of kinase II (CrkII) in ovarian cancer and analyze their clinical significance. To explore ... an...
Cervical cancer is one of the most common female ... were obtained using data from GTEx and The Cancer Genome Atlas (TCGA) database. The functionalities ... that were associated with the prognosis of cervical cancer
To investigate the alterations of peripheral lymphocyte subpopulations in ovarian cancer patients compared to benign or borderline counterparts....
A diagnosis of advanced ovarian cancer is the beginning of a long and ... half of the individuals undergoing therapy for advanced cancer will succumb to the disease, or consequences ... -fluorouracil, and doxorub...
Ovarian cancer is a common malignant tumor in women, ... causes, pathogenesis, recurrence and metastasis of ovarian cancer, and early diagnosis and treatment still face ... . The sensitivity and specificity of ex...
Ceramide plays an important role in the occurrence and development of tumor. The synthesis of ceramide needs the participation of LASS. Current studies have shown that different LASS family members play different...
Ovarian cancer (OC) is the most lethal gynecologic...
A leading theory for ovarian carcinogenesis proposes that inflammation associated with incessant ovulation is a driver of oncogenesis. Consistent with this theory, nonsteroidal anti-inflammatory drugs (NSAIDs) ex...
Ovarian cancer is the fifth most common cause of cancer death in women and the leading cause ... initiating events and early developmental stages of ovarian cancer, lack of reliable ovarian cancer-specific biomar...
Individual patients with ovarian cancer show remarkably different prognosis. Present prognostic models for ovarian cancer mainly focus on clinico-pathological parameters, so ... are urgently needed. Platelets con...
MUC16 (CA125) is a commonly used tumor marker for ovarian cancer screening and reported to be an immunosuppressive...
New biomarkers that replace or are used in conjunction with the current ovarian cancer diagnostic antigen, CA125, are needed for detection of ovarian cancer in the presurgical setting, as well as ... 1 (LRG1) in ...
Autophagy is a lysosomal-driven catabolic process that contributes to preserve cell and tissue homeostases through the regular elimination of damaged, aged and redundant self-constituents. In normal cells, autoph...
Recently, increasing evidence has indicated that elevation of Hexokinase 2 (HK2) plays an important role in several cancers on regulating cell motility and growth. However ... role on regulating cell EMT in human...
To construct a machine learning diagnostic model integrating feature dimensionality reduction techniques and artificial neural network classifiers to develop the value of clinical routine blood indexes for the au...
Ovarian cancer is the most lethal gynecologic neoplasm, and ... the promising immunotherapy showed limited efficacy in ovarian cancer, probably due to the immunosuppressive microenvironment. ... the immune exclus...
The most frequently used molecular imaging technique is currently 18F-deoxy-glucose (FDG) positron emission tomography (PET). FDG-PET holds promise in the evaluation of recurrent or residual ovarian cancer when C...
Ubiquitin-binding enzyme E2T (UBE2T), a member of the E2 family of the ubiquitin–proteasome pathway, is associated with tumorigenesis of varioustumours; however, its role and mechanism in ovarian cancer remain un...
Epithelial ovarian cancer (EOC) is still a major gynecologic ... expression of microRNAs is widely dysregulated in ovarian cancer; and that they have evolved into tumorigenic...
Ovarian cancer is one of the most common malignant ... However, the role of Cul4B in ovarian cancer has not been studied.
The present study aimed to investigate whether baicalein improves the sensitivity of resistant ovarian cancer cells to cisplatin.
Ovarian cancer is a disease with increasing incidence worldwide, ... However, the role of SLFN5 in ovarian cancer cells has not been fully elucidated. Samples were collected from patients with ovarian cancer diag...
It is known that the new membrane-bound estrogen receptor GPER-1 acts suppressive in breast cancer cells and its expression decreases during disease ... to evaluate the GPER-1 expression in ovarian cancer and its...
The five-year overall survival (OS) of advanced-stage ovarian cancer remains nearly 25-35%, although several ... heterogeneity and complexity has been seen in ovarian cancer. This study aimed to establish gene si...
Gynecologic cancers comprise malignancies in the female reproductive organs. Ovarian cancer ranks sixth in terms of incidence rates ... mortality rates. The stage at which ovarian cancer is diagnosed mainly deter...
Ovarian epithelial tumors are an hallmark of hereditary cancer syndromes which are related to the germ-line inheritance of cancer predisposing mutations in BRCA1 and BRCA2 genes. ... 2-related as compared to "spo...
As a kind of gynecological tumor, ovarian cancer is not as common as cervical cancer and breast cancer, but its malignant degree is higher. Despite the increasingly mature treatment of ovarian cancer, the five-ye...
To explore the association between ovulation induction drugs and ovarian cancer.
Detailed epidemiologic descriptions of large populations of advanced stage ovarian cancer patients have been lacking to date. This ... in a large cohort of advanced stage ovarian cancer patients in the United Sta...
MTHFD2 is a folate-coupled metabolic enzyme, which has been proved to participant in the metabolic reprogramming and tumor cell-sustaining proliferative capacity. However, the function of MTHFD2 in the developmen...
Cervical cancer is considered as an important malignancy among women worldwide. Currently-used treatments of cervical cancer are reported to be cytotoxic for patients. ... affect the lives of women suffering from...
Ovarian cancer is the leading cause of cancer-related death among women. Complete cytoreductive surgery ... drug, metformin, has cytotoxic activity in different cancer models. However, the synergism of metformin ...
This study intended to clarify the mechanisms by which WISP1-mediated IGF1/αvβ3/Wnt axis might affect the progression of ovarian cancer.
The mortality rate of epithelial ovarian cancer (EOC) remains the first in malignant ... extensive implanted metastasis, and treatment resistance of cancer cells require an extensive metabolism rewiring during th...
Ovarian cancer is the fifth most common cancer among women and causes more deaths than any other type of female reproductive cancer. Currently, treatment of ovarian cancer is based on the combination of surgery a...
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