Articles

Prognostic value of various subtypes of extracellular DNA in ovarian cancer patients

Patients with ovarian cancer represent a heterogeneous population with a variable prognosis and response to chemotherapy. Plasma DNA has been shown to have a prognostic value in different types of cancer inclu...

Authors: Katarina Kalavska, Tomas Minarik, Barbora Vlkova, Denisa Manasova, Michaela Kubickova, Andrej Jurik, Jozef Mardiak, Jozef Sufliarsky, Peter Celec and Michal Mego

Assessment of Prostaglandin-Endoperoxide Synthase 2 and Versican gene expression profile from the cumulus cells: association with better in vitro fertilization outcomes

Current methods for determining superior embryo quality (morphological assessment) are unable to compensate for poor pregnancy outcomes. Due to the importance of the cumulus-oocyte complex and the value of cum...

Authors: Azucena Ocampo, Jeimy Pedraza, Ginna Ortiz, Elizabeth Hernández-Pérez, Leonardo Porchia and Esther López-Bayghen

Gonadotropin and steroid hormones regulate pluripotent very small embryonic-like stem cells in adult mouse uterine endometrium

Very small embryonic-like stem cells (VSELs) exist in adult organs, express pluripotent markers and have the ability to differentiate into three germ layers in vitro. Testicular, ovarian and hematopoietic stem/pr...

Authors: Kreema James, Deepa Bhartiya, Ranita Ganguly, Ankita Kaushik, Kavita Gala, Pushpa Singh and S. M. Metkari

Non-classical 11β-hydroxylase deficiency caused by compound heterozygous mutations: a case study and literature review

11β-hydroxylase deficiency (11OHD) is extremely rare, and reports of non-classical 11OHD are even rarer. Non-classical 11OHD usually presents as premature adrenarche, hyperandrogenism, menstrual disorders, and...

Authors: Dongdong Wang, Jiahui Wang, Tong Tong and Qing Yang

Exosomal miR-1290 is a potential biomarker of high-grade serous ovarian carcinoma and can discriminate patients from those with malignancies of other histological types

microRNAs (miRNAs) stably exist in circulating blood encapsulated in extracellular vesicles such as exosomes; therefore, serum miRNAs have the potential to serve as novel cancer biomarkers. New diagnostic mark...

Authors: Masaki Kobayashi, Kenjiro Sawada, Koji Nakamura, Akihiko Yoshimura, Mayuko Miyamoto, Aasa Shimizu, Kyoso Ishida, Erika Nakatsuka, Michiko Kodama, Kae Hashimoto, Seiji Mabuchi and Tadashi Kimura

The effects of probiotic and selenium co-supplementation on parameters of mental health, hormonal profiles, and biomarkers of inflammation and oxidative stress in women with polycystic ovary syndrome

The aim of this study was to evaluate the effect of the co-administration of probiotic and selenium on parameters of mental health, hormonal profiles, and biomarkers of inflammation and oxidative stress in wom...

Authors: Mehri Jamilian, Shirin Mansury, Fereshteh Bahmani, Zahra Heidar, Elaheh Amirani and Zatollah Asemi

Persistent megalocystic ovaries after ovarian hyperstimulation syndrome in a postpartum patient with polycystic ovarian syndrome: a case report

Ovary enlargement is common in controlled ovarian stimulation, which could continue several months during a successful pregnancy. However, persistent megalocystic ovaries 3 years after ovarian hyperstimulation...

Authors: Jinghua Shi, Xinyu Ren, Qinjie Tian, Aijun Sun and Rong Chen

Does a poor-quality embryo have an adverse impact on a good-quality embryo when transferred together?

In some in vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI) cycles, we may consider transferring one poor-quality embryo with one good-quality embryo. Previous studies have indicated that t...

Authors: Jiaheng Li, Mingze Du, Zhan Zhang, Yichun Guan, Xingling Wang, Xiao Zhang, Jing Liu, Zhouhui Pan, Bijun Wang and Wenxia Liu

Anaplastic carcinoma in ovarian seromucinous cystic tumor of borderline malignancy

The mortality rate of ovarian cancer is the highest among all gynecological malignancies in Japan. Ovarian tumors are classified as benign, borderline malignant, or malignant. Anticipating the histological sub...

Authors: Toshiyuki Okumura, Etuo Muronosono, Masahiko Tsubuku, Yasuhisa Terao, Satoru Takeda and Masanori Maruyama

Pregnancy after drug-free in vitro activation of follicles and fresh tissue autotransplantation in primary ovarian insufficiency patient: a case report and literature review

The aim of this report was to describe a case of pregnancy after drug-free in vitro activation (IVA) of follicles and fresh tissue autotransplantation in primary ovarian insufficiency (POI) patient and to revi...

Authors: F. Fabregues, J. Ferreri, J.M. Calafell, V. Moreno, A. Borrás, D. Manau and F. Carmona

Ovarian teratoma in children: a plea for collaborative clinical study

Although teratomas are the most common histologic subtype of childhood ovarian germ cell tumors, their appropriate treatment in this age group still remains unclear. Paucity of research dedicated exclusively t...

Authors: Justyna Łuczak and Maciej Bagłaj

A case of ovarian clear cell carcinoma arising from ovarian mature cystic teratoma

It is well known that ovarian mature cystic teratomas (MCTs) occasionally go through malignant transformations. Among these, approximately 75% of histological types are squamous cell carcinoma, with the other ...

Authors: Kazuya Maeda, Yoshito Terai, Shinichi Terada, Hiroshi Maruoka, Yuhei Kogata, Keisuke Ashihara, Yoshimichi Tanaka, Tomohito Tanaka, Hiroshi Sasaki, Satoshi Tsunetoh, Takashi Yamada and Masahide Ohmichi

The value of MRI for differentiating benign from malignant sex cord-stromal tumors of the ovary: emphasis on diffusion-weighted MR imaging

To investigate MRI for differentiating benign from malignant sex cord-stromal tumors of the ovary (SCSTs) emphasizing on the value of diffusion-weighted (DW) magnetic resonance (MR) imaging.

Authors: Shu-Hui Zhao, Hai-Ming Li, Jin-Wei Qiang, Deng-Bin Wang and Hua Fan

Use of a Small Animal Radiation Research Platform (SARRP) facilitates analysis of systemic versus targeted radiation effects in the mouse ovary

Radiation exposure is known to cause accelerated aging and damage to the ovary, but the contribution of indirect versus direct effects is not well understood. We used the Small Animal Radiation Research Platfo...

Authors: Allison R. Grover, Bruce F. Kimler and Francesca E. Duncan

The role of vitamin D in ovarian cancer: epidemiology, molecular mechanism and prevention

Vitamin D is a fat-soluble prohormone best known for its role in maintaining calcium homeostasis. Large numbers of epidemiological studies have shown that vitamin D plays an important role in cancer prevention...

Authors: Hui Guo, Jing Guo, Wenli Xie, Lingqin Yuan and Xiugui Sheng

Live birth rate after human chorionic gonadotropin priming in vitro maturation in women with polycystic ovary syndrome

In vitro maturation (IVM) has some advantages over conventional in vitro fertilization (IVF), particularly in polycystic ovary syndrome (PCOS) where the risk of ovarian hyperstimulation is high. We studied the...

Authors: V. N. A. Ho, T. D. Pham, A. H. Le, T. M. Ho and L. N. Vuong

Characterization of stem cell and cancer stem cell populations in ovary and ovarian tumors

Ovarian cancer is a complicated malady associated with cancer stem cells (CSCs) contributing to 238,700 estimated new cases and 151,900 deaths per year, worldwide. CSCs comprise a tiny fraction of tumor-bulk r...

Authors: Seema C. Parte, Surinder K. Batra and Sham S. Kakar

Low fertility may be a significant determinant of ovarian cancer worldwide: an ecological analysis of cross- sectional data from 182 countries

Ageing, socioeconomic level, obesity, fertility, relaxed natural selection and urbanization have been postulated as the risk factors of ovarian cancer (OC56). We sought to identify which factor plays the most ...

Authors: Wenpeng You, Ian Symonds and Maciej Henneberg

Comparative study of endometrioid borderline ovarian tumor with and without endometriosis

Synchronous endometriosis has been poorly studied in women with endometrioid borderline ovarian tumors (EBOTs). The aims of this study were to compare the clinicopathological features and prognosis of EBOTs wi...

Authors: Wen Zhang, Shuangzheng Jia, Yang Xiang, Junjun Yang, Congwei Jia and Jinhua Leng

Reproductive aging and elective fertility preservation

Reproductive aging is a natural process that occurs in all women, eventually leading to reproductive senescence and menopause. Over the past half century there has been a trend towards delayed motherhood. Post...

Authors: Rani Fritz and Sangita Jindal

Innovative multi-protectoral approach increases survival rate after vitrification of ovarian tissue and isolated follicles with improved results in comparison with conventional method

In recent years, autotransplantation of cryopreserved ovarian tissue became a promising approach to preserve female fertility. The slow freezing is the most effective technique which resulted in greater live b...

Authors: Dmitry Nikiforov, Valentina Russo, Delia Nardinocchi, Nicola Bernabò, Mauro Mattioli and Barbara Barboni

Characterization of ovarian cancer cells and tissues by Fourier transform infrared spectroscopy

Ovarian cancer is the most lethal of gynecological malignancies. Fourier Transform Infrared (FTIR) spectroscopy has gradually developed as a convenient, inexpensive and non-destructive technique for the study ...

Authors: Lei Li, Xiaoning Bi, Hengzi Sun, Simiao Liu, Mei Yu, Ying Zhang, Shifu Weng, Limin Yang, Yanan Bao, Jinguang Wu, Yizhuang Xu and Keng Shen

Predicted luteal phase length has no influence on success of vitrified-warmed blastocyst transfer in natural cycle

This study evaluated the influence of menstrual cycle length, menstrual cycle variability and predicted luteal phase length on the success of vitrified-warmed blastocyst transfer in natural menstrual cycle usi...

Authors: M. Reljič and J. Knez

Is the ovarian reserve influenced by vitamin D deficiency and the dress code in an infertile Iranian population?

In the recent years, vitamin D has become a topical subject and a focus of research not only in reproductive medicine but across many medical disciplines. In reproductive medicine, studies have identified an a...

Authors: Soheila Arefi, Gholamreza Khalili, Homa Iranmanesh, Fattaneh Farifteh, Ahmad Hosseini, Human M. Fatemi and Barbara Lawrenz

Determination of sialic acid in saliva by means of surface-enhanced Raman spectroscopy as a marker in adnexal mass patients: ovarian cancer vs benign cases

To demonstrate the use of surface-enhanced Raman spectroscopy (SERS) to determine sialic acid (SA) levels in saliva using silver nanoparticles as substrates, in adnexal mass patients scheduled for surgical int...

Authors: José de Jesús Zermeño-Nava, Marco Ulises Martínez-Martínez, Ana Laura Rámirez-de-Ávila, Aida Catalina Hernández-Arteaga, Ma. Guadalupe García-Valdivieso, Alondra Hernández-Cedillo, Miguel José-Yacamán and Hugo Ricardo Navarro-Contreras

Discordant anti-müllerian hormone (AMH) and follicle stimulating hormone (FSH) among women undergoing in vitro fertilization (IVF): which one is the better predictor for live birth?

This study sought to clarify the roles of Anti-müllerian hormone (AMH) and follicle stimulating hormone (FSH) in predicting live birth, especially in patients with discordant AMH and FSH. A large IVF data set ...

Authors: Shunping Wang, Yi Zhang, Virginia Mensah, Warren J. Huber III, Yen-Tsung Huang and Ruben Alvero

Fresh versus frozen embryo transfer for full-term singleton birth: a retrospective cohort study

Improvements in vitrification and frozen embryo transfer (FET) technologies have rapidly increased, and some evidence suggests that FET may increase pregnancy rates and lead to more favourable perinatal outcom...

Authors: Junwei Zhang, Mingze Du, Zhe Li, Lulu Wang, Jijun Hu, Bei Zhao, Yingying Feng, Xiaolin Chen and Lijun Sun

Establishment and molecular characterization of a human ovarian clear cell carcinoma cell line (FDOV1)

Ovarian clear cell carcinoma is a distinct histologic subtype with grave survival. The underlying molecular mechanism is not fully elucidated. However, we don’t have many cell lines, which are useful experimen...

Authors: Wei Jiang, Shuang Ye, Libing Xiang, Wentao Yang, Tiancong He, Xuan Pei, Lin Guo and Huijuan Yang

Expression of Concern to: Does ovary need D-chiro-inositol?

Authors: Rosalbino Isabella and Emanuela Raffone

Wounding promotes ovarian cancer progression and decreases efficacy of cisplatin in a syngeneic mouse model

Primary cytoreductive surgery followed by adjuvant chemotherapy is the standard treatment for advanced epithelial ovarian cancer. The average interval between surgery and chemotherapy initiation is approximate...

Authors: Yooyoung Lee, Alexandra Kollara, Taymaa May and Theodore J. Brown

Effect of resveratrol and metformin on ovarian reserve and ultrastructure in PCOS: an experimental study

PCOS is a reproductive hormonal abnormality and a metabolic disorder. It is frequently associated with insulin resistance, hyperandrogenism, chronic inflammation, and oxidative stress. We aim to investigate th...

Authors: Selenay Furat Rencber, Sema Kurnaz Ozbek, Ceyla Eraldemır, Zehra Sezer, Tugba Kum, Sureyya Ceylan and Elif Guzel

Age-dependent difference in impact of fertility preserving surgery on disease-specific survival in women with stage I borderline ovarian tumors

This study was to determine age-specific impact of fertility preserving surgery on disease-specific survival in women with stage I borderline ovarian tumors (BOTs). Patients diagnosed during 1988–2000 were sel...

Authors: Haiyan Sun, Xi Chen, Tao Zhu, Nanfang Liu, Aijun Yu and Shihua Wang

Endometriosis does not confer improved prognosis in ovarian clear cell carcinoma: a retrospective study at a single institute

Considered as the precursor lesion of a subset of ovarian clear cell carcinoma (OCCC), the prognostic role of endometriosis in OCCC patients remains controversial. This study aimed to investigate the prognosti...

Authors: Ting Zhao, Yu Shao, Yan Liu, Xiao Wang, Luyao Guan and Yuan Lu

Alpha-fetoprotein-producing ovarian clear cell adenocarcinoma with fetal gut differentiation: a rare case report and literature review

Alpha-fetoprotein (AFP) is a useful tumor marker for ovarian germ cell tumors, particularly yolk sac tumor (YST). It is valuable for both diagnosis and further follow-up. Epithelial ovarian carcinoma (EOC) rar...

Authors: Wei-Ting Chao, Chia-Hao Liu, Chiung-Ru Lai, Yi-Jen Chen, Chi-Mu Chuang and Peng-Hui Wang

Quercetin increases the antioxidant capacity of the ovary in menopausal rats and in ovarian granulosa cell culture in vitro

Menopause is the most important sign of aging in women, and the ovary is the organ most sensitive to aging. Quercetin is a potential antioxidant and free radical scavenger that is widely found in fruits, veget...

Authors: Jiao Wang, Xin Qian, Qiang Gao, Chunmei Lv, Jie Xu, Hongbo Jin and Hui Zhu

DNA damage repair in ovarian cancer: unlocking the heterogeneity

Treatment for advanced ovarian cancer is rarely curative; three quarters of patients with advanced disease relapse and ultimately die with resistant disease. Improving patient outcomes will require the introdu...

Authors: Mary Ellen Gee, Zahra Faraahi, Aiste McCormick and Richard J. Edmondson

Clinical study of a CT evaluation model combined with serum CA125 in predicting the treatment of newly diagnosed advanced epithelial ovarian cancer

The treatment of newly diagnosed advanced epithelial ovarian cancer (EOC) was predicted by an ovarian cancer computed tomography (CT) evaluation model combined with serum CA125.

Authors: Lu Qin, Huming Huang, Mengjie Chen, Yuejuan Liang and He Wang

Consanguineous familial study revealed biallelic FIGLA mutation associated with premature ovarian insufficiency

To dissect the genetic alteration in two sisters with premature ovarian insufficiency (POI) from a consanguineous family.

Authors: Beili Chen, Lin Li, Jing Wang, Tengyan Li, Hong Pan, Beihong Liu, Yiran Zhou, Yunxia Cao and Binbin Wang

HE4 level in ascites may assess the ovarian cancer chemotherapeutic effect

The clinical treatment of ovarian cancer with ascites is problematic. The main reasons for treatment failure are the susceptibility to intraperitoneal metastasis and chemotherapeutic drug resistance. The purpo...

Authors: Duanyang Liu, Dan Kong, Jing Li, Lei Gao, Di Wu, Yu Liu, Weiwei Yang, Lei Zhang, Jiang Zhu and Xiaoming Jin

MR findings of primary ovarian granulosa cell tumor with focus on the differentiation with other ovarian sex cord-stromal tumors

To describe magnetic resonance imaging (MRI) features of ovarian granulosa cell tumors (OGCTs) and compare with other sex cord-stromal tumors (OSCs) in ovary.

Authors: He Zhang, Hongyu Zhang, Shouxin Gu, Yanyu Zhang, Xuefen Liu and Guofu Zhang

Comparison of the influence of three fibroid treatment options: supracervical hysterectomy, ulipristal acetate and uterine artery embolization on ovarian reserve – an observational study

To assess and compare the influence of three fibroid treatment options: supracervical hysterectomy, ulipristal acetate and uterine artery embolization on ovarian reserve.

Authors: Piotr Czuczwar, Anna Stepniak, Pawel Milart, Tomasz Paszkowski and Slawomir Wozniak

Superficially invasive cervical squamous cell carcinoma metastatic to ovarian endometriotic cyst wall, a case report and brief review of the literature

Although cases of cervical squamous cell carcinoma metastatic to the ovary have been previously documented, we report the first case of superficially invasive squamous cell carcinoma metastatic to the ovary.

Authors: Minfen Zhang, Elena Lucas, Hanzhen Xiong, Shaoyan Liu, Kyle Molberg, Qingping Jiang and Wenxin Zheng

Stratification of ovarian tumor pathology by expression of programmed cell death-1 (PD-1) and PD-ligand- 1 (PD-L1) in ovarian cancer

Ovarian cancer is the major cause of death among gynecologic cancers with 75% of patients diagnosed with advanced disease, and only 20% of these patients having a survival duration of five years. Treatments bl...

Authors: Maureen L. Drakes, Swati Mehrotra, Monica Aldulescu, Ronald K. Potkul, Yueying Liu, Anne Grisoli, Cara Joyce, Timothy E. O’Brien, M. Sharon Stack and Patrick J. Stiff

A predictive score for optimal cytoreduction at interval debulking surgery in epithelial ovarian cancer: a two- centers experience

Optimal cytoreduction (macroscopic Residual Tumor, RT = 0) is the best survival predictor factor in epithelial ovarian cancer (EOC). It doesn’t exist a consolidated criteria to predict optimal surgical resecti...

Authors: Eleonora Ghisoni, Dionyssios Katsaros, Furio Maggiorotto, Massimo Aglietta, Marco Vaira, Michele De Simone, Gloria Mittica, Gaia Giannone, Manuela Robella, Sofia Genta, Fabiola Lucchino, Francesco Marocco, Fulvio Borella, Giorgio Valabrega and Riccardo Ponzone

Preoperative assessment of ovarian tumors using a modified multivariate index assay

Preoperative differentiation between benign and malignant masses can be challenging. The aim of this research was to evaluate the performance of a modified multivariate index assay (MIA) in detecting ovarian c...

Authors: Hero A. Abdurrahman, Ariana Kh. Jawad and Shahla K. Alalalf

Clinical analysis of chemo-resistance risk factors in endometriosis associated ovarian cancer

To analyze the clinical characteristics and chemo-resistance related factors of patients with resistant and non-resistant endometriosis-associated ovarian cancer (ovarian clear cell carcinoma and endometrioid ...

Authors: Tong Ren, Ting-Ting Sun, Shu Wang, Jian Sun, Yang Xiang, Keng Shen and Jing-He Lang

S-allylcysteine suppresses ovarian cancer cell proliferation by DNA methylation through DNMT1

The anti-tumor effects of S-allylcysteine (SAC), a water-soluble garlic derivative, on human ovarian cancer cells have been previous studied in vitro and in vivo models but the precise epigenetic molecular mec...

Authors: Yasi Xu, Dan Su, Lucheng Zhu, Shirong Zhang, Shenglin Ma, Kan Wu, Qiang Yuan and Nengming Lin

Effects of myo-inositol plus alpha-lactalbumin in myo-inositol-resistant PCOS women

Myo-inositol (MI), successfully used in polycystic ovary syndrome (PCOS), was administered with α-LA to exploit its action of favouring the passage of other molecules through biological barriers, and also cons...

Authors: Mario Montanino Oliva, Giovanna Buonomo, Marco Calcagno and Vittorio Unfer

Low dose clomiphene citrate as a mild stimulation protocol in women with unsuspected poor in vitro fertilization result can generate more oocytes with optimal cumulative pregnancy rate

The use of long protocol during controlled ovarian stimulation for assisted reproduction attracts high dosage of gonadotropins. High dose of gonadotropins can be detrimental to oocyte development, which affect...

Authors: Humphrey Ochin, Xiang Ma, Lin Wang, Xuan Li, Jie Song, Yan Meng, Jiandong Shen, Yu-Gui Cui and Jiayin Liu

Nanog interaction with the androgen receptor signaling axis induce ovarian cancer stem cell regulation: studies based on the CRISPR/Cas9 system

Ovarian cancer stem cells (OCSCs) contribute to the poor prognosis of ovarian cancer. Involvement of the androgen receptor (AR) in the malignant behaviors of other tumors has been reported. However, whether AR...

Authors: Kaijian Ling, Lupin Jiang, Shi Liang, Joseph Kwong, Leiyan Yang, Yudi Li, PingYin, Qingchun Deng and Zhiqing Liang