Articles

Characterization of stem cell and cancer stem cell populations in ovary and ovarian tumors

Ovarian cancer is a complicated malady associated with cancer stem cells (CSCs) contributing to 238,700 estimated new cases and 151,900 deaths per year, worldwide. CSCs comprise a tiny fraction of tumor-bulk r...

Authors: Seema C. Parte, Surinder K. Batra and Sham S. Kakar

Low fertility may be a significant determinant of ovarian cancer worldwide: an ecological analysis of cross- sectional data from 182 countries

Ageing, socioeconomic level, obesity, fertility, relaxed natural selection and urbanization have been postulated as the risk factors of ovarian cancer (OC56). We sought to identify which factor plays the most ...

Authors: Wenpeng You, Ian Symonds and Maciej Henneberg

Reproductive aging and elective fertility preservation

Reproductive aging is a natural process that occurs in all women, eventually leading to reproductive senescence and menopause. Over the past half century there has been a trend towards delayed motherhood. Post...

Authors: Rani Fritz and Sangita Jindal

Comparative study of endometrioid borderline ovarian tumor with and without endometriosis

Synchronous endometriosis has been poorly studied in women with endometrioid borderline ovarian tumors (EBOTs). The aims of this study were to compare the clinicopathological features and prognosis of EBOTs wi...

Authors: Wen Zhang, Shuangzheng Jia, Yang Xiang, Junjun Yang, Congwei Jia and Jinhua Leng

Innovative multi-protectoral approach increases survival rate after vitrification of ovarian tissue and isolated follicles with improved results in comparison with conventional method

In recent years, autotransplantation of cryopreserved ovarian tissue became a promising approach to preserve female fertility. The slow freezing is the most effective technique which resulted in greater live b...

Authors: Dmitry Nikiforov, Valentina Russo, Delia Nardinocchi, Nicola Bernabò, Mauro Mattioli and Barbara Barboni

Characterization of ovarian cancer cells and tissues by Fourier transform infrared spectroscopy

Ovarian cancer is the most lethal of gynecological malignancies. Fourier Transform Infrared (FTIR) spectroscopy has gradually developed as a convenient, inexpensive and non-destructive technique for the study ...

Authors: Lei Li, Xiaoning Bi, Hengzi Sun, Simiao Liu, Mei Yu, Ying Zhang, Shifu Weng, Limin Yang, Yanan Bao, Jinguang Wu, Yizhuang Xu and Keng Shen

Predicted luteal phase length has no influence on success of vitrified-warmed blastocyst transfer in natural cycle

This study evaluated the influence of menstrual cycle length, menstrual cycle variability and predicted luteal phase length on the success of vitrified-warmed blastocyst transfer in natural menstrual cycle usi...

Authors: M. Reljič and J. Knez

Determination of sialic acid in saliva by means of surface-enhanced Raman spectroscopy as a marker in adnexal mass patients: ovarian cancer vs benign cases

To demonstrate the use of surface-enhanced Raman spectroscopy (SERS) to determine sialic acid (SA) levels in saliva using silver nanoparticles as substrates, in adnexal mass patients scheduled for surgical int...

Authors: José de Jesús Zermeño-Nava, Marco Ulises Martínez-Martínez, Ana Laura Rámirez-de-Ávila, Aida Catalina Hernández-Arteaga, Ma. Guadalupe García-Valdivieso, Alondra Hernández-Cedillo, Miguel José-Yacamán and Hugo Ricardo Navarro-Contreras

Is the ovarian reserve influenced by vitamin D deficiency and the dress code in an infertile Iranian population?

In the recent years, vitamin D has become a topical subject and a focus of research not only in reproductive medicine but across many medical disciplines. In reproductive medicine, studies have identified an a...

Authors: Soheila Arefi, Gholamreza Khalili, Homa Iranmanesh, Fattaneh Farifteh, Ahmad Hosseini, Human M. Fatemi and Barbara Lawrenz

Discordant anti-müllerian hormone (AMH) and follicle stimulating hormone (FSH) among women undergoing in vitro fertilization (IVF): which one is the better predictor for live birth?

This study sought to clarify the roles of Anti-müllerian hormone (AMH) and follicle stimulating hormone (FSH) in predicting live birth, especially in patients with discordant AMH and FSH. A large IVF data set ...

Authors: Shunping Wang, Yi Zhang, Virginia Mensah, Warren J. Huber III, Yen-Tsung Huang and Ruben Alvero

Fresh versus frozen embryo transfer for full-term singleton birth: a retrospective cohort study

Improvements in vitrification and frozen embryo transfer (FET) technologies have rapidly increased, and some evidence suggests that FET may increase pregnancy rates and lead to more favourable perinatal outcom...

Authors: Junwei Zhang, Mingze Du, Zhe Li, Lulu Wang, Jijun Hu, Bei Zhao, Yingying Feng, Xiaolin Chen and Lijun Sun

Establishment and molecular characterization of a human ovarian clear cell carcinoma cell line (FDOV1)

Ovarian clear cell carcinoma is a distinct histologic subtype with grave survival. The underlying molecular mechanism is not fully elucidated. However, we don’t have many cell lines, which are useful experimen...

Authors: Wei Jiang, Shuang Ye, Libing Xiang, Wentao Yang, Tiancong He, Xuan Pei, Lin Guo and Huijuan Yang

Expression of Concern to: Does ovary need D-chiro-inositol?

Authors: Rosalbino Isabella and Emanuela Raffone

Wounding promotes ovarian cancer progression and decreases efficacy of cisplatin in a syngeneic mouse model

Primary cytoreductive surgery followed by adjuvant chemotherapy is the standard treatment for advanced epithelial ovarian cancer. The average interval between surgery and chemotherapy initiation is approximate...

Authors: Yooyoung Lee, Alexandra Kollara, Taymaa May and Theodore J. Brown

Effect of resveratrol and metformin on ovarian reserve and ultrastructure in PCOS: an experimental study

PCOS is a reproductive hormonal abnormality and a metabolic disorder. It is frequently associated with insulin resistance, hyperandrogenism, chronic inflammation, and oxidative stress. We aim to investigate th...

Authors: Selenay Furat Rencber, Sema Kurnaz Ozbek, Ceyla Eraldemır, Zehra Sezer, Tugba Kum, Sureyya Ceylan and Elif Guzel

Age-dependent difference in impact of fertility preserving surgery on disease-specific survival in women with stage I borderline ovarian tumors

This study was to determine age-specific impact of fertility preserving surgery on disease-specific survival in women with stage I borderline ovarian tumors (BOTs). Patients diagnosed during 1988–2000 were sel...

Authors: Haiyan Sun, Xi Chen, Tao Zhu, Nanfang Liu, Aijun Yu and Shihua Wang

Endometriosis does not confer improved prognosis in ovarian clear cell carcinoma: a retrospective study at a single institute

Considered as the precursor lesion of a subset of ovarian clear cell carcinoma (OCCC), the prognostic role of endometriosis in OCCC patients remains controversial. This study aimed to investigate the prognosti...

Authors: Ting Zhao, Yu Shao, Yan Liu, Xiao Wang, Luyao Guan and Yuan Lu

Alpha-fetoprotein-producing ovarian clear cell adenocarcinoma with fetal gut differentiation: a rare case report and literature review

Alpha-fetoprotein (AFP) is a useful tumor marker for ovarian germ cell tumors, particularly yolk sac tumor (YST). It is valuable for both diagnosis and further follow-up. Epithelial ovarian carcinoma (EOC) rar...

Authors: Wei-Ting Chao, Chia-Hao Liu, Chiung-Ru Lai, Yi-Jen Chen, Chi-Mu Chuang and Peng-Hui Wang

Quercetin increases the antioxidant capacity of the ovary in menopausal rats and in ovarian granulosa cell culture in vitro

Menopause is the most important sign of aging in women, and the ovary is the organ most sensitive to aging. Quercetin is a potential antioxidant and free radical scavenger that is widely found in fruits, veget...

Authors: Jiao Wang, Xin Qian, Qiang Gao, Chunmei Lv, Jie Xu, Hongbo Jin and Hui Zhu

DNA damage repair in ovarian cancer: unlocking the heterogeneity

Treatment for advanced ovarian cancer is rarely curative; three quarters of patients with advanced disease relapse and ultimately die with resistant disease. Improving patient outcomes will require the introdu...

Authors: Mary Ellen Gee, Zahra Faraahi, Aiste McCormick and Richard J. Edmondson

Consanguineous familial study revealed biallelic FIGLA mutation associated with premature ovarian insufficiency

To dissect the genetic alteration in two sisters with premature ovarian insufficiency (POI) from a consanguineous family.

Authors: Beili Chen, Lin Li, Jing Wang, Tengyan Li, Hong Pan, Beihong Liu, Yiran Zhou, Yunxia Cao and Binbin Wang

Clinical study of a CT evaluation model combined with serum CA125 in predicting the treatment of newly diagnosed advanced epithelial ovarian cancer

The treatment of newly diagnosed advanced epithelial ovarian cancer (EOC) was predicted by an ovarian cancer computed tomography (CT) evaluation model combined with serum CA125.

Authors: Lu Qin, Huming Huang, Mengjie Chen, Yuejuan Liang and He Wang

HE4 level in ascites may assess the ovarian cancer chemotherapeutic effect

The clinical treatment of ovarian cancer with ascites is problematic. The main reasons for treatment failure are the susceptibility to intraperitoneal metastasis and chemotherapeutic drug resistance. The purpo...

Authors: Duanyang Liu, Dan Kong, Jing Li, Lei Gao, Di Wu, Yu Liu, Weiwei Yang, Lei Zhang, Jiang Zhu and Xiaoming Jin

MR findings of primary ovarian granulosa cell tumor with focus on the differentiation with other ovarian sex cord-stromal tumors

To describe magnetic resonance imaging (MRI) features of ovarian granulosa cell tumors (OGCTs) and compare with other sex cord-stromal tumors (OSCs) in ovary.

Authors: He Zhang, Hongyu Zhang, Shouxin Gu, Yanyu Zhang, Xuefen Liu and Guofu Zhang

Comparison of the influence of three fibroid treatment options: supracervical hysterectomy, ulipristal acetate and uterine artery embolization on ovarian reserve – an observational study

To assess and compare the influence of three fibroid treatment options: supracervical hysterectomy, ulipristal acetate and uterine artery embolization on ovarian reserve.

Authors: Piotr Czuczwar, Anna Stepniak, Pawel Milart, Tomasz Paszkowski and Slawomir Wozniak

Stratification of ovarian tumor pathology by expression of programmed cell death-1 (PD-1) and PD-ligand- 1 (PD-L1) in ovarian cancer

Ovarian cancer is the major cause of death among gynecologic cancers with 75% of patients diagnosed with advanced disease, and only 20% of these patients having a survival duration of five years. Treatments bl...

Authors: Maureen L. Drakes, Swati Mehrotra, Monica Aldulescu, Ronald K. Potkul, Yueying Liu, Anne Grisoli, Cara Joyce, Timothy E. O’Brien, M. Sharon Stack and Patrick J. Stiff

Superficially invasive cervical squamous cell carcinoma metastatic to ovarian endometriotic cyst wall, a case report and brief review of the literature

Although cases of cervical squamous cell carcinoma metastatic to the ovary have been previously documented, we report the first case of superficially invasive squamous cell carcinoma metastatic to the ovary.

Authors: Minfen Zhang, Elena Lucas, Hanzhen Xiong, Shaoyan Liu, Kyle Molberg, Qingping Jiang and Wenxin Zheng

A predictive score for optimal cytoreduction at interval debulking surgery in epithelial ovarian cancer: a two- centers experience

Optimal cytoreduction (macroscopic Residual Tumor, RT = 0) is the best survival predictor factor in epithelial ovarian cancer (EOC). It doesn’t exist a consolidated criteria to predict optimal surgical resecti...

Authors: Eleonora Ghisoni, Dionyssios Katsaros, Furio Maggiorotto, Massimo Aglietta, Marco Vaira, Michele De Simone, Gloria Mittica, Gaia Giannone, Manuela Robella, Sofia Genta, Fabiola Lucchino, Francesco Marocco, Fulvio Borella, Giorgio Valabrega and Riccardo Ponzone

Clinical analysis of chemo-resistance risk factors in endometriosis associated ovarian cancer

To analyze the clinical characteristics and chemo-resistance related factors of patients with resistant and non-resistant endometriosis-associated ovarian cancer (ovarian clear cell carcinoma and endometrioid ...

Authors: Tong Ren, Ting-Ting Sun, Shu Wang, Jian Sun, Yang Xiang, Keng Shen and Jing-He Lang

Preoperative assessment of ovarian tumors using a modified multivariate index assay

Preoperative differentiation between benign and malignant masses can be challenging. The aim of this research was to evaluate the performance of a modified multivariate index assay (MIA) in detecting ovarian c...

Authors: Hero A. Abdurrahman, Ariana Kh. Jawad and Shahla K. Alalalf

S-allylcysteine suppresses ovarian cancer cell proliferation by DNA methylation through DNMT1

The anti-tumor effects of S-allylcysteine (SAC), a water-soluble garlic derivative, on human ovarian cancer cells have been previous studied in vitro and in vivo models but the precise epigenetic molecular mec...

Authors: Yasi Xu, Dan Su, Lucheng Zhu, Shirong Zhang, Shenglin Ma, Kan Wu, Qiang Yuan and Nengming Lin

Effects of myo-inositol plus alpha-lactalbumin in myo-inositol-resistant PCOS women

Myo-inositol (MI), successfully used in polycystic ovary syndrome (PCOS), was administered with α-LA to exploit its action of favouring the passage of other molecules through biological barriers, and also cons...

Authors: Mario Montanino Oliva, Giovanna Buonomo, Marco Calcagno and Vittorio Unfer

Low dose clomiphene citrate as a mild stimulation protocol in women with unsuspected poor in vitro fertilization result can generate more oocytes with optimal cumulative pregnancy rate

The use of long protocol during controlled ovarian stimulation for assisted reproduction attracts high dosage of gonadotropins. High dose of gonadotropins can be detrimental to oocyte development, which affect...

Authors: Humphrey Ochin, Xiang Ma, Lin Wang, Xuan Li, Jie Song, Yan Meng, Jiandong Shen, Yu-Gui Cui and Jiayin Liu

Successful fertility following optimized perfusion and cryopreservation of whole ovary and allotransplantation in a premature ovarian insufficiency rat model

Fertility preservation by whole ovary cryopreservation and transplantation (WOCP&TP) with vascular anastomosis requires successful cryopreservation. In this study, we investigated the possibility of restoring ...

Authors: Yan Ding, Jia-liang Shao, Jun-wei Li, Ying Zhang, Kai-hua Hong, Ke-qin Hua and Xiang Wang

Nanog interaction with the androgen receptor signaling axis induce ovarian cancer stem cell regulation: studies based on the CRISPR/Cas9 system

Ovarian cancer stem cells (OCSCs) contribute to the poor prognosis of ovarian cancer. Involvement of the androgen receptor (AR) in the malignant behaviors of other tumors has been reported. However, whether AR...

Authors: Kaijian Ling, Lupin Jiang, Shi Liang, Joseph Kwong, Leiyan Yang, Yudi Li, PingYin, Qingchun Deng and Zhiqing Liang

MicroRNA-424/503 cluster members regulate bovine granulosa cell proliferation and cell cycle progression by targeting SMAD7 gene through activin signalling pathway

The granulosa cells are indispensable for follicular development and its function is orchestrated by several genes, which in turn posttranscriptionally regulated by microRNAs (miRNA). In our previous study, th...

Authors: Hari Om Pande, Dawit Tesfaye, Michael Hoelker, Samuel Gebremedhn, Eva Held, Christiane Neuhoff, Ernst Tholen, Karl Schellander and Dessie Salilew Wondim

Beneficial effects of curcumin and capsaicin on cyclophosphamide-induced premature ovarian failure in a rat model

In recent years, cancer rates have been rising among reproductive-age women. Thus, chemotherapy exposure has become an important cause of premature ovarian failure (POF). There has been growing interest regard...

Authors: Rauf Melekoglu, Osman Ciftci, Sevil Eraslan, Asli Cetin and Nese Basak

KLK10 exon 3 unmethylated PCR product concentration: a new potential early diagnostic marker in ovarian cancer? - A pilot study

KLK10 exon 3 hypermethylation correlated to tumor-specific lack of KLK10 expression in cancer cell lines and primary tumors. In the present study we investigate the possible role of KLK10 exon 3 methylation in ov...

Authors: Mustafa A. El Sherbini, Amal A. Mansour, Maha M. Sallam, Emtiaz A. Shaban, Zeinab A. Shehab ElDin and Amr H. El-Shalakany

Role of BMI1 in epithelial ovarian cancer: investigated via the CRISPR/Cas9 system and RNA sequencing

B-cell-specific Moloney murine leukemia virus integration site 1 (BMI1) might be an appropriate biomarker in the management of epithelial ovarian cancer (EOC). However, the biological role of BMI1 and its rele...

Authors: Qianying Zhao, Qiuhong Qian, Dongyan Cao, Jiaxin Yang, Ting Gui and Keng Shen

Risk of synchronous endometrial disorders in women with endometrioid borderline tumors of the ovary

Synchronous endometrial disorders have been poorly studied in women with endometrioid borderline ovarian tumors (EBOT). The aims of this study were to investigate the risk of endometrial disorders among women ...

Authors: Shuang-zheng Jia, Jun-ji Zhang, Jun-jun Yang, Yang Xiang, Zhiyong Liang and Jin-hua Leng

Adipokine RBP4 drives ovarian cancer cell migration

Obesity has been linked to several types of cancers including ovarian cancer. Retinol binding protein 4 (RBP4) is an adipokine that drives the development of hyperinsulinemia and type II diabetes in obesity pa...

Authors: Yanyan Wang, Yilin Wang and Zhenyu Zhang

Transparency in ovarian cancer clinical trial results: ClinicalTrials.gov versus PubMed, Embase and Google scholar

In recent years the question of the lack of transparency in clinical research has been debated by clinicians, researchers, citizens and their representatives, authors and publishers. This is particularly impor...

Authors: Anna Roberto, Silvia Radrezza and Paola Mosconi

Deregulation of the spindle assembly checkpoint is associated with paclitaxel resistance in ovarian cancer

Ovarian cancer is the leading gynecologic cancer diagnosed in North America and because related symptoms are not disease specific, this often leads to late detection, an advanced disease state, and the need fo...

Authors: Taryne Chong, Amila Sarac, Cindy Q. Yao, Linda Liao, Nicola Lyttle, Paul C. Boutros, John M. S. Bartlett and Melanie Spears

Therapeutic potentials of Quercetin in management of polycystic ovarian syndrome using Letrozole induced rat model: a histological and a biochemical study

PCOS is a leading endocrinopathy of young women instigating androgens elevation, insulin resistance, obesity, cardiometabolic and menstrual complications. The study investigated the effects of quercetin in a l...

Authors: Sarwat Jahan, Abira Abid, Sidra Khalid, Tayyaba Afsar, Qurat-Ul-Ain, Ghazala Shaheen, Ali Almajwal and Suhail Razak

Is adjuvant chemotherapy beneficial for patients with FIGO stage IC adult granulosa cell tumor of the ovary?

To evaluate the association between adjuvant chemotherapy and clinical outcomes in patients with stage IC adult granulosa cell tumor (AGCT).

Authors: Dan Wang, Yang Xiang, Ming Wu, Keng Shen, Jiaxin Yang, Huifang Huang and Tong Ren

Pioglitazone is effective for multiple phenotyepes of the Zucker fa/fa rat with polycystc ovary morphology and insulin resistance

Hyperandrogenism and insulin resistance may be related to the etiology of PCOS. Zucker fa/fa rats with polycystic ovary are obese, have insulin resistance without diabetes mellitus or hyperandrogenism and can ...

Authors: Miyuki Morishita, Toshiaki Endo, Tsuyoshi Baba, Yoshika Kuno, Keiko Ikeda, Tamotsu Kiya, Hiroyuki Honnma and Tsuyoshi Saito

With low ovarian reserve, Highly Individualized Egg Retrieval (HIER) improves IVF results by avoiding premature luteinization

Highly Individualized Egg Retrieval (HIER), defined as age-specific early oocyte retrieval (ER), has been demonstrated to avoid premature luteinization in women ≥43. We here investigated whether HIER also appl...

Authors: Yan-Guang Wu, David H. Barad, Vitaly A. Kushnir, Qi Wang, Lin Zhang, Sarah K. Darmon, David F. Albertini and Norbert Gleicher

Cross-linked hyaluronan gel inhibits the growth and metastasis of ovarian carcinoma

The recurrence, metastasis and poor prognosis are important characteristics of ovarian carcinoma (OC), which are associated with exfoliation of cells from the primary tumor and colonization of the cells in pel...

Authors: Ji Pang, Pengcheng Jiang, Ying Wang, Lu Jiang, Hai Qian, Yan Tao, Ruxia Shi, Jizong Gao, Yongchang Chen and Yan Wu

Does the primary route of spread have a prognostic significance in stage III non-serous epithelial ovarian cancer?

The purpose of this retrospective study was to determine the prognosis of non-serous epithelial ovarian cancer (EOC) patients with exclusively retroperitoneal lymph node (LN) metastases, and to compare the pro...

Authors: Hanifi Sahin, Mehmet Mutlu Meydanli, Mustafa Erkan Sari, Ibrahim Yalcin, Gonca Çoban, Nazlı Topfedaisi Ozkan, Zeliha Firat Cuylan, Baki Erdem, Kemal Gungorduk, Özgür Akbayir, Murat Dede, Mustafa Coşkun Salman, Tayfun Güngör and Ali Ayhan

Comparison of benign peritoneal fluid- and ovarian cancer ascites-derived extracellular vesicle RNA biomarkers

Extracellular vesicles (EVs) are considered as a new class of resources for potential biomarkers. We analyzed expression of specific mRNA and miRNA in EVs derived from ovarian cancer ascites and the ideal cont...

Authors: Cindy M. Yamamoto, Melanie L. Oakes, Taku Murakami, Michael G. Muto, Ross S. Berkowitz and Shu-Wing Ng