Articles

Identification of significant genes with poor prognosis in ovarian cancer via bioinformatical analysis

Ovarian cancer (OC) is the highest frequent malignant gynecologic tumor with very complicated pathogenesis. The purpose of the present academic work was to identify significant genes with poor outcome and thei...

Authors: Hao Feng, Zhong-Yi Gu, Qin Li, Qiong-Hua Liu, Xiao-Yu Yang and Jun-Jie Zhang

A potential function of RLIP76 in the ovarian corpus luteum

Ral interacting protein of 76 kDa (RLIP76) is multifunctional protein localized and distributed in the plasma membrane, cytosol, and nucleus of the cell. In tumorigenesis, RLIP76 emerges as a common feature fo...

Authors: Dody Houston Billhaq and Seunghyung Lee

The prognosis impact of hyperthermic intraperitoneal chemotherapy (HIPEC) plus cytoreductive surgery (CRS) in advanced ovarian cancer: the meta-analysis

Previous studies about the prognostic value of the HIPEC have yielded controversial results. Therefore, this study aims to assess the impact of HIPEC on patients with ovarian cancer.

Authors: Guyu Zhang, Yimin Zhu, Chongdong Liu, Guangming Chao, Ran Cui and Zhenyu Zhang

A rare case of ovarian carcinosarcoma with squamous cell carcinoma

Ovarian carcinosarcoma, which contains sarcomatous and carcinomatous components, is a very rare tumor. The carcinomatous component is often adenocarcinoma, and squamous cell carcinoma is extremely rare. We her...

Authors: Atsushi Daimon, Satoe Fujiwara, Yoshimichi Tanaka, Tomohito Tanaka and Masahide Ohmichi

Androgen potentiates the expression of FSH receptor and supports preantral follicle development in mice

Hyperandrogenism is one of the cardinal symptoms in polycystic ovary syndrome and plays a key role in the pathogenesis of polycystic ovary syndrome. However, the precise effects and mechanisms of excess androg...

Authors: Yuya Fujibe, Tsuyoshi Baba, Sachiko Nagao, Sayaka Adachi, Keiko Ikeda, Miyuki Morishita, Yoshika Kuno, Masahiro Suzuki, Masahito Mizuuchi, Hiroyuki Honnma, Toshiaki Endo and Tsuyoshi Saito

Tomm34 is commonly expressed in epithelial ovarian cancer and associates with tumour type and high FIGO stage

Increased activity of the chaperones Hsp70 and Hsp90 is a common feature of solid tumours. Translocase of the outer mitochondrial membrane 34 (Tomm34) is a cochaperone of both Hsp70 and Hsp90 that was found to...

Authors: Petr Muller, Philip J. Coates, Rudolf Nenutil, Filip Trcka, Roman Hrstka, Josef Chovanec, Veronika Brychtova and Borivoj Vojtesek

Postoperative recurrence of epithelial ovarian cancer patients and chemoresistance related protein analyses

To identify the plasma protein biomarkers related to the chemoresistance of postoperative recurrence of epithelial ovarian cancers.

Authors: Zhengmao Zhang, Kaiyun Qin, Wenzhe Zhang, Botao Yang, Chen Zhao, Xiaojing Zhang, Fenghua Zhang, Lianmei Zhao and Baoen Shan

Biomarkers and algorithms for diagnosis of ovarian cancer: CA125, HE4, RMI and ROMA, a review

Ovarian cancer is the 5th leading cause of death for women with cancer worldwide. In more than 70% of cases, it is only diagnosed at an advanced stage. Our study aims to give an update on the biological marker...

Authors: Vincent Dochez, Hélène Caillon, Edouard Vaucel, Jérôme Dimet, Norbert Winer and Guillaume Ducarme

Effects of hysterectomy with simultaneous bilateral salpingectomy on the subsequent pelvic mass

To analyze the clinicopathological characteristics of subsequent pelvic masses after hysterectomy for benign diseases, and to compare the masses following hysterectomy with or without simultaneous bilateral sa...

Authors: Xiaopei Chao, Xiaoxia Wang, Yu Xiao, Mingliang Ji, Shu Wang, Honghui Shi, Qingbo Fan, Lan Zhu, Jinhua Leng, Dawei Sun and Jinghe Lang

Melatonin is a potential inhibitor of ovarian cancer: molecular aspects

Ovarian cancer is one of the most common causes of morbidity related to gynecologic malignancies. Possible risk factors are including hereditary ovarian cancer, obesity, diabetes mellitus, alcohol consumption,...

Authors: Hadis Zare, Rana Shafabakhsh, Russel J. Reiter and Zatollah Asemi

Metabolomic change due to combined treatment with myo-inositol, D-chiro-inositol and glucomannan in polycystic ovarian syndrome patients: a pilot study

Polycystic ovarian syndrome (PCOS) is a highly variable syndrome and one of the most common female endocrine disorders. Although the association inositols-glucomannan may represent a good therapeutic strategy ...

Authors: Jacopo Troisi, Claudia Cinque, Luigi Giugliano, Steven Symes, Sean Richards, David Adair, Pierpaolo Cavallo, Laura Sarno, Giovanni Scala, Maria Caiazza and Maurizio Guida

Circulating microRNAs as novel potential diagnostic biomarkers for ovarian cancer: a systematic review and updated meta-analysis

Ovarian cancer is the primary cause of cancer-associated deaths among gynaecological malignancies. Increasing evidence suggests that microRNAs may be potential biomarkers for the diagnosis and prognosis of can...

Authors: Xinshuai Wang, Dejiu Kong, Chaokun Wang, Xuezhen Ding, Li Zhang, Mengqi Zhao, Jing Chen, Xiangyun Xu, Xiaochen Hu, Junqiang Yang and Shegan Gao

Expression of zinc finger transcription factors (ZNF143 and ZNF281) in serous borderline ovarian tumors and low-grade ovarian cancers

Low-grade ovarian cancers represent up to 8% of all epithelial ovarian carcinomas (EOCs). Recent studies demonstrated that epithelial-mesenchymal transition (EMT) is crucial for the progression of EOCs. EMT pl...

Authors: Paweł Sadłecki, Marek Grabiec, Dariusz Grzanka, Jakub Jóźwicki, Paulina Antosik and Małgorzata Walentowicz-Sadłecka

The ovarian germinal reserve and apoptosis-related proteins in the infant and adolescent human ovary

Normal pubertal ovary displays all stages of follicular development and a biased BAX/BCL2 protein ratio in favor of pro-apoptotic BAX protein comparable to the adult ovary. However, adolescents suffering malig...

Authors: María Itatí Albamonte, Mirta Susana Albamonte, Ricardo M. Bou-Khair, Luis Zuccardi and Alfredo Daniel Vitullo

HAS2-AS1 is a novel LH/hCG target gene regulating HAS2 expression and enhancing cumulus cells migration

The cumulus expansion process is one of the LH mediated ovulatory processes. Hyaluronan synthase 2 (HAS2) regulates the synthesis of hyaluronic acid, the main component of the cumulus expansion process. Recent...

Authors: Yuval Yung, Libby Ophir, Gil M. Yerushalmi, Micha Baum, Ariel Hourvitz and Ettie Maman

Magnetic resonance imaging findings for discriminating clear cell carcinoma and endometrioid carcinoma of the ovary

Common cancerous histological types associated with endometriosis are clear cell carcinoma (CCC) and endometrioid carcinoma (EC). CCC is regarded as an aggressive, chemoresistant histological subtype. Magnetic...

Authors: Sachiko Morioka, Ryuji Kawaguchi, Yuki Yamada, Kana Iwai, Chiharu Yoshimoto and Hiroshi Kobayashi

Next-generation sequencing-based genomic profiling analysis reveals novel mutations for clinical diagnosis in Chinese primary epithelial ovarian cancer patients

Ovarian cancer (OC) is one of the most malignant gynecological tumors, associated with excess death rate (50–60%) in ovarian cancer patients. Particularly, among newly occurred ovarian cancer patients, 70% of ...

Authors: Lei Zhang, Min Luo, Hongying Yang, Shaoyan Zhu, Xianliang Cheng and Chen Qing

Defining a murine ovarian cancer model for the evaluation of conditionally-replicative adenovirus (CRAd) virotherapy agents

Virotherapy represents a promising approach for ovarian cancer. In this regard, conditionally replicative adenovirus (CRAd) has been translated to the context of human clinical trials. Advanced design of CRAds...

Authors: Rebeca González-Pastor, Ahmad Mohammad Ashshi, Adel Galal El-Shemi, Igor P. Dmitriev, Elena A. Kashentseva, Zhi Hong Lu, S. Peter Goedegebuure, Osvaldo L. Podhajcer and David T. Curiel

TOP2A as marker of response to pegylated lyposomal doxorubicin (PLD) in epithelial ovarian cancers

Relapsed epithelial ovarian cancer (EOC) is frequently treated with pegylated liposomal doxorubicin (PLD). Unfortunately, most patients do not benefit from treatment. Prediction of response is crucial to optim...

Authors: Eleonora Ghisoni, Furio Maggiorotto, Fulvio Borella, Gloria Mittica, Sofia Genta, Gaia Giannone, Dionyssios Katsaros, Alberto Sciarrillo, Annamaria Ferrero, Ivana Sarotto, Jessica Erriquez, Maria Flavia Di Renzo, Massimo Aglietta and Giorgio Valabrega

Can complete blood count inflammatory parameters in epithelial ovarian cancer contribute to prognosis? - a survival analysis

The aim of the present study was to investigate the prognostic significance of preoperative complete blood count inflammatory markers in women operated for invasive Epithelial Ovarian Cancer (EOC).

Authors: Mehmet Ufuk Ceran, Umit Tasdemir, Eser Colak and Tayfun Güngör

Progesterone reduces cell survival in primary cultures of endometrioid ovarian cancer

Ovarian cancer is the most lethal of all gynecologic malignancies. The relationship between sexual steroids receptors and ovarian cancer progression has been largely evaluated. The presence of progesterone rec...

Authors: Enrique Pedernera, María J. Gómora, Flavia Morales-Vásquez, Delia Pérez-Montiel and Carmen Mendez

Aberrant DNA methylation suppresses expression of estrogen receptor 1 (ESR1) in ovarian endometrioma

In ovarian endometriomas (OE), the expression statuses of various steroid hormone receptors are altered compared with their expression statuses in eutopic endometrium (EE). For example, in OE, the expressions ...

Authors: Ryo Maekawa, Yumiko Mihara, Shun Sato, Maki Okada, Isao Tamura, Masahiro Shinagawa, Yuichiro Shirafuta, Haruka Takagi, Toshiaki Taketani, Hiroshi Tamura and Norihiro Sugino

Syzygium cumini (L.) Skeels improves metabolic and ovarian parameters in female obese rats with malfunctioning hypothalamus-pituitary-gonadal axis

Obesity is a chronic and multifactorial disease characterized by increased adipose tissue. In females, obesity leads to reduced ovulation and lower chances of conception in diseases like polycystic ovary syndr...

Authors: R. O. A. Benevides, C. C. Vale, J. L. L. Fontelles, L. M. França, T. S. Teófilo, S. N. Silva, A. M. A. Paes and R. S. Gaspar

The ability of whole-body SUVmax in F-18 FDG PET/CT to predict suboptimal cytoreduction during primary debulking surgery for advanced ovarian cancer

The aim of this study was to (1) evaluate the ability of F-18 fluorodeoxyglucose positron emission tomography/computed tomography (FDG PET/CT) parameters to predict suboptimal cytoreduction and (2) to create a...

Authors: Gun Oh. Chong, Shin Young Jeong, Yoon Hee Lee, Hyun Jung Lee, Sang-Woo Lee, Hyung Soo Han, Dae Gy Hong and Yoon Soon Lee

Correction to: Nanog interaction with the androgen receptor signaling axis induce ovarian cancer stem cell regulation: studies based on the CRISPR/Cas9 system

Abstract

Authors: Kaijian Ling, Lupin Jiang, Shi Liang, Joseph Kwong, Leiyan Yang, Yudi Li, PingYin, Qingchun Deng and Zhiqing Liang

Comparison and analysis of the clinicopathological features of SCEO and ECOM

The aim of our study was to evaluate and compare the differences in the clinicopathological variables and overall survival (OS) of synchronous primary cancers of the endometrium and ovary (SCEO) and endometria...

Authors: Ting Wang, Xiaodan Zhang, Zhiying Lu, Junyan Wang and Keqin Hua

Current strategies for the targeted treatment of high-grade serous epithelial ovarian cancer and relevance of BRCA mutational status

Epithelial ovarian cancer is the most lethal gynecologic malignancy. In most women, it is diagnosed at an advanced stage, which largely explains the poor prognosis of this malignancy. Germline mutations of the...

Authors: Angiolo Gadducci, Valentina Guarneri, Fedro Alessandro Peccatori, Graziana Ronzino, Giuseppa Scandurra, Claudio Zamagni, Paolo Zola and Vanda Salutari

Low dose human chorionic gonadotropin administration at the time of gonadotropin releasing-hormone agonist trigger versus 35 h later in women at high risk of developing ovarian hyperstimulation syndrome – a prospective randomized double-blind clinical trial

Ovarian hyperstimulation syndrome remains a serious complication during in vitro fertilization cycles if high dose human chorionic gonadotropin (hCG) is used to trigger ovulation in high responder patients. Th...

Authors: L. L. Engmann, B. S. Maslow, L. A. Kaye, D. W. Griffin, A. J. DiLuigi, D. W. Schmidt, D. R. Grow, J. C. Nulsen and C. A. Benadiva

Association of the hypoxia-inducible factor-1α (HIF-1α) gene polymorphisms with prognosis in ovarian clear cell carcinoma

Ovarian clear cell carcinoma (OCCC) is the second most common ovarian cancer after serous carcinoma in Japan. OCCC has a more unfavorable clinical outcome due to a poor response to platinum-based chemotherapy,...

Authors: Hiroyuki Suzuki, Mitsutake Yano, Mariko Miyazawa, Masaki Miyazawa, Naoki Ogane, Kosei Hasegawa, Hitoshi Tsuda, Masayuki Yoshida, Ryugo Okagaki, Osamu Ishihara and Masanori Yasuda

Upregulated expression of serum exosomal miR-375 and miR-1307 enhance the diagnostic power of CA125 for ovarian cancer

Ovarian cancer (OC) is associated with high mortality in gynecological oncology; this is mainly due to the low diagnosis rate. Exosomal miRNA has demonstrated potential as a tumor biomarker. We aimed to explor...

Authors: Ying Ying Su, Li Sun, Zhi Rui Guo, Jin Chang Li, Ting Ting Bai, Xiao Xiao Cai, Wen Han Li and Ye Fei Zhu

Vitamin D and probiotic co-supplementation affects mental health, hormonal, inflammatory and oxidative stress parameters in women with polycystic ovary syndrome

The aim of this study was to determine the effect of vitamin D and probiotic co-administration on mental health, hormonal, inflammatory and oxidative stress parameters in women with polycystic ovary syndrome (...

Authors: Vahidreza Ostadmohammadi, Mehri Jamilian, Fereshteh Bahmani and Zatollah Asemi

Overexpression of CCDC69 activates p14^ARF/MDM2/p53 pathway and confers cisplatin sensitivity

The aim of the study is to explore the relationship between CCDC69 expression and resistance of ovarian cancer cells to cisplatin and reveal the underlying mechanism.

Authors: Long Cui, Fang Zhou, Cui Chen and Chi Chiu Wang

The role of the endocannabinoid system in female reproductive tissues

There has been increasing interest in the role of endocannabinoids as critical modulators of the female reproductive processes. Endocannabinoids are natural ligands of cannabinoid, vanilloid, and peroxisome pr...

Authors: O’Llenecia S. Walker, Alison C. Holloway and Sandeep Raha

Recurrent ovarian mixed germ cell tumor with unusual malignant transformation: a case report

The value of this report is the identification of late recurrence with an extremely unusual combination of malignant transformation. In particular, the retroconversion of immature to mature teratoma as well as...

Authors: Yi-Le Lee, Chiung-Ru Lai and Ming-Shyen Yen

Cancer-testis antigens in ovarian cancer: implication for biomarkers and therapeutic targets

Ovarian cancer remains the most fatal gynecologic malignancy worldwide due to delayed diagnosis as well as recurrence and drug resistance. Thus, the development of new tumor-related molecules with high sensiti...

Authors: Kaipeng Xie, Chenyang Fu, Suli Wang, Hanzi Xu, Siyu Liu, Yang Shao, Zhen Gong, Xiaoli Wu, Bo Xu, Jing Han, Juan Xu, Pengfei Xu, Xuemei Jia and Jiangping Wu

Diversity of imaging features of ovarian sclerosing stromal tumors on MRI and PET-CT: a case report and literature review

Sclerosing stromal tumors (SST) are rare, benign tumors classified as sex cord stromal tumors. To our knowledge, positron emission tomography with computed tomography (PET-CT) findings of SST have only been de...

Authors: Hiroki Matsutani, Go Nakai, Takashi Yamada, Kazuhiro Yamamoto, Masahide Ohmichi and Yoshifumi Narumi

Rapidly growing juvenile granulosa cell tumor of the ovary arising in adult: a case report and review of the literature

Ovarian granulosa cell tumors (GCTs) are divided into adult GCT (AGCT) and juvenile GCT (JGCT). The AGCT is more common type, conversely, less than 5% of tumors are the JGCT and occur in mainly premenarchal gi...

Authors: Yuki Inada, Go Nakai, Kazuhiro Yamamoto, Takashi Yamada, Yoshinobu Hirose, Yoshito Terai, Masahide Ohmichi and Yoshifumi Narumi

Protective role of Ficus deltoidea against BPA-induced impairments of the follicular development, estrous cycle, gonadotropin and sex steroid hormones level of prepubertal rats

Ficus deltoidea is one of the well-known medicinal plants in Malaysia that is traditionally used by the Malay community to treat various ailments and for maintenance of female reproductive health. The objective o...

Authors: Siti Sarah Mohamad Zaid, Shatrah Othman and Normadiah M. Kassim

Expression of Concern to: Does ovary need D-chiro-inositol?

Authors: Rosalbino Isabella and Emanuela Raffone

Isolated ovarian tuberculosis in an Immuno- competent woman in the post partum period: case report

Pelvic tuberculosis is a rare form of extrapulmonary tuberculosis. It commonly involves the fallopian tubes and the uterus from a lympho-hematogeneous spread. The presentation of pelvic tuberculosis as an isol...

Authors: Wondimu Gudu

Decrease in preovulatory serum estradiol is a valuable marker for predicting premature ovulation in natural/unstimulated in vitro fertilization cycle

Premature ovulation occurs at a high rate in natural-cycle in vitro fertilization (IVF), and cycle cancellation further hampers the overall efficiency of the procedure. While lower levels of estradiol (E2) are...

Authors: Xuefeng Lu, Shuzin Khor, Qianqian Zhu, Lihua Sun, Yun Wang, Qiuju Chen, Ling Wu, Yonglun Fu, Hui Tian, Qifeng Lyu, Renfei Cai and Yanping Kuang

Is the aging human ovary still ticking?: Expression of clock-genes in luteinized granulosa cells of young and older women

It has been shown – mostly in animal models - that circadian clock genes are expressed in granulosa cells and in corpora luteum and might be essential for the ovulatory process and steroidogenesis.

Authors: Amnon Brzezinski, A. Saada, H. Miller, NA Brzezinski-Sinai and A. Ben-Meir

Identification of core genes in ovarian cancer by an integrative meta-analysis

Epithelial ovarian cancer is one of the most severe public health threats in women. Since it is still challenging to screen in early stages, identification of core genes that play an essential role in epithel...

Authors: Wenyu Li, Zheran Liu, Bowen Liang, Siyang Chen, Xinping Zhang, Xiaoqin Tong, Weiming Lou, Lulu Le, Xiaoli Tang and Fen Fu

Luteolin sensitizes the antitumor effect of cisplatin in drug-resistant ovarian cancer via induction of apoptosis and inhibition of cell migration and invasion

Luteolin, a polyphenolic flavone, has been demonstrated to exert anti-tumor activity in various cancer types. Cisplatin drug resistance is a major obstacle in the management of ovarian cancer. In the present s...

Authors: Haixia Wang, Youjun Luo, Tiankui Qiao, Zhaoxia Wu and Zhonghua Huang

Diagnostic value of the gynecology imaging reporting and data system (GI-RADS) with the ovarian malignancy marker CA-125 in preoperative adnexal tumor assessment

The purpose of this study is to assess the preoperative evaluation of an adnexal mass using the GI-RADS classification and to verify whether CA-125 measurement can offer any additional benefits to the GI-RADS-...

Authors: Michal Migda, Migda Bartosz, Marian S. Migda, Marcin Kierszk, Gieryn Katarzyna and Marek Maleńczyk

Comparison of stage III mucinous and serous ovarian cancer: a case-control study

The purpose of this case-control study was to compare the prognoses of women with stage III mucinous ovarian carcinoma (MOC) who received maximal or optimal cytoreduction followed by paclitaxel plus carboplati...

Authors: Zeliha Firat Cuylan, Emine Karabuk, Murat OZ, Ahmet Taner Turan, Mehmet M. Meydanli, Salih Taskin, Mustafa Erkan Sari, Hanifi Sahin, Suat C. Ulukent, Ozgur Akbayir, Kemal Gungorduk, Tayfun Gungor, Mehmet F. Kose and Ali Ayhan

DAXX promotes ovarian cancer ascites cell proliferation and migration by activating the ERK signaling pathway

The death-domain-associated protein (DAXX) was originally identified as a protein that binds to the transmembrane death receptor FAS and enhances both FAS-induced and transforming growth factor-β-dependent apo...

Authors: Sheng-Bing Liu, Xue-Ping Lin, Ying Xu, Zhong-Fei Shen and Wei-Wei Pan

Mitochondrial membrane depolarization enhances TRAIL-induced cell death in adult human granulosa tumor cells, KGN, through inhibition of BIRC5

Cellular metabolic changes that accompany malignant transformation have been heralded as hallmark features of cancer. However, metabolic signatures between neoplasms can be unique, allowing for distinctions in...

Authors: Julie A. MacDonald, Niharika Kura, Carleigh Sussman and Dori C. Woods

Mass spectrometry-based proteomics techniques and their application in ovarian cancer research

Ovarian cancer has emerged as one of the leading cause of gynecological malignancies. So far, the measurement of CA125 and HE4 concentrations in blood and transvaginal ultrasound examination are essential ovar...

Authors: Agata Swiatly, Szymon Plewa, Jan Matysiak and Zenon J. Kokot

CT of ovarian cancer: 3D cinematic rendering for preoperative evaluation

Ovarian cancer is the second most common gynecologic malignancy. As the primary imaging modality, computed tomography (CT) can provide staging information for preoperative planning and determination of surgica...

Authors: Yi-ren Jin, Xie-lan Yang, Qin-qing Li, Zhi-ling Yan, Hong-ying Yang and Chengde Liao