Articles

Long non-coding RNA PTPRG-AS1 promotes cell tumorigenicity in epithelial ovarian cancer by decoying microRNA-545-3p and consequently enhancing HDAC4 expression

Long non-coding RNA PTPRG antisense RNA 1 (PTPRG-AS1) deregulation has been reported in various human malignancies and identified as an important modulator of cancer development. Few reports have focused on th...

Authors: Juanjuan Shi, Xijian Xu, Dan Zhang, Jiuyan Zhang, Hui Yang, Chang Li, Rui Li, Xuan Wei, Wenqing Luan and Peishu Liu

Effects of activating GABAB1 receptor on proliferation, migration, invasion and epithelial-mesenchymal transition of ovarian cancer cells

This study aimed to explore the effects of activating GABAB1 receptor by baclofen on proliferation, migration, invasion and epithelial-mesenchymal transition (EMT) of ovarian cancer cells.

Authors: Jun Gao, Yao Gao, Shixin Lin, Xia Zou, Yukai Zhu, Xintong Chen, Hong Wan and Hong Zhu

Prognostic value of kallikrein-related peptidase 7 (KLK7) mRNA expression in advanced high-grade serous ovarian cancer

High-grade serous ovarian cancer (HGSOC) is the most common and lethal subtype of ovarian cancer. A growing body of evidence suggests tumor-supporting roles of several members of the kallikrein-related peptida...

Authors: Weiwei Gong, Yueyang Liu, Eleftherios P. Diamandis, Marion Kiechle, Holger Bronger, Julia Dorn, Tobias Dreyer and Viktor Magdolen

Prediction of the treatment response in ovarian cancer: a ctDNA approach

Ovarian cancer is the eighth most commonly occurring cancer in women. Clinically, the limitation of conventional screening and monitoring approaches inhibits high throughput analysis of the tumor molecular mar...

Authors: Mina Sharbatoghli, Somayeh Vafaei, Hamidreza Aboulkheyr Es, Mohsen Asadi-Lari, Mehdi Totonchi and Zahra Madjd

Development and validation of Nomograms for predicting overall survival and Cancer-specific survival in patients with ovarian clear cell carcinoma

Ovarian clear cell carcinoma (OCCC) is a rare histologic type of ovarian cancer. There is a lack of an efficient prognostic predictive tool for OCCC in clinical work. This study aimed to construct and validate...

Authors: Qian Chen, Shu Wang and Jing-He Lang

LINC01094/miR-577 axis regulates the progression of ovarian cancer

Long intergenic non-coding RNA 01094 (LINC01094) is probably a novel regulator in cancer biology. This study aimed to probe into the function and mechanism of LINC01094 in ovarian cancer (OC).

Authors: Jing Xu, Ping Zhang, Huajun Sun and Yang Liu

Comparison of methods for quantifying primordial follicles in the mouse ovary

Accurate evaluation of primordial follicle numbers in mouse ovaries is an essential endpoint for studies investigating how endogenous and exogenous insults, such as maternal aging and chemotherapy, impact the ...

Authors: Urooza C. Sarma, Amy L. Winship and Karla J. Hutt

Bioinformatics analysis of prognostic value and prospective pathway signal of miR-30a in ovarian cancer

MicroRNAs (MiRNAs) is thought to play a critical role in the initiation and progress of ovarian cancer (OC). Although miRNAs has been widely recognized in ovarian cancer, the role of hsa-miR-30a-5p (miR-30a) in.....

Authors: Weijia Lu, Yunyu Wu, Can Xiong Lu, Ting Zhu, Zhong Lu Ren and Zhiwu Yu

Identification of WTAP-related genes by weighted gene co-expression network analysis in ovarian cancer

Wilms tumor 1 associated protein (WTAP) modulates other genes via transcriptional and post-transcriptional regulation, in particular, by acting as a N6-methyladenosine writer or binding to the 3’UTR of mRNA, a...

Authors: Jing Wang, Jing Xu, Ke Li, Yunke Huang, Yilin Dai, Congjian Xu and Yu Kang

Patient with ovarian insufficiency: baby born after anticancer therapy and re-transplantation of cryopreserved ovarian tissue

The second major cause of death is cancer. In fact, the effectiveness of anticancer treatments and positive long-term prognosis for young women has increased. However, the problem of post-cancer infertility pl...

Authors: Vladimir Isachenko, Bernd Morgenstern, Plamen Todorov, Evgenia Isachenko, Peter Mallmann, Bettina Hanstein and Gohar Rahimi

Predicting complete cytoreduction for advanced ovarian cancer patients using nearest-neighbor models

The foundation of modern ovarian cancer care is cytoreductive surgery to remove all macroscopic disease (R0). Identification of R0 resection patients may help individualise treatment. Machine learning and AI h...

Authors: Alexandros Laios, Alexandros Gryparis, Diederick DeJong, Richard Hutson, Georgios Theophilou and Chris Leach

Integrative analysis of the common genetic characteristics in ovarian cancer stem cells sorted by multiple approaches

Ovarian cancer is the second fatal malignancy of the female reproductive system. Based on the cancer stem cell (CSC) theory, its poor prognosis of ovarian cancer attributed to tumor recurrence caused by CSCs. ...

Authors: Xiaoxiao Zhang, Yue Su, Xue Wu, Rourou Xiao, Yifan Wu, Bin Yang, Zhen Wang, Lili Guo, Xiaoyan Kang and Changyu Wang

Adipocytes: active facilitators in epithelial ovarian cancer progression?

There is growing evidence that adipocytes play important roles in the progression of multiple cancers. Moreover, in obesity, adipocytes alter their original functions and contribute to the metabolic and inflam...

Authors: Lan Dai, Keqi Song and Wen Di

Whole-exome sequencing in patients with premature ovarian insufficiency: early detection and early intervention

The loss of ovarian function in women, referred to as premature ovarian insufficiency (POI), is associated with a series of concomitant diseases. POI is genetically heterogeneous, and in most cases, the etiolo...

Authors: Hongli Liu, Xiaoli Wei, Yanwei Sha, Wensheng Liu, Haijie Gao, Jin Lin, Youzhu Li, Yaling Tang, Yifeng Wang, Yanlong Wang and Zhiying Su

The role of apatinib combined with paclitaxel (aluminum binding type) in platinum-resistant ovarian cancer

To assess the anti-tumor activity and side effects of different dosages of paclitaxel (albumin binding type) (hereinafter referred to as nab-P) combined with Apatinib (hereinafter referred to as AP) in platinu...

Authors: Hong Zhao, Rong Li, Xiaoyan Wang, Xin Lu, Min Hu, Jinbin Zhang, Xia Zhao, Xiaoqin Song and Yangyang Liu

A novel signature of two long non-coding RNAs in BRCA mutant ovarian cancer to predict prognosis and efficiency of chemotherapy

In this study we aimed to identify a prognostic signature in BRCA1/2 mutations to predict disease progression and the efficiency of chemotherapy ovarian cancer (OV), the second most common cause of death from gyn...

Authors: Yinglian Pan, Li Ping Jia, Yuzhu Liu, Yiyu Han, Qian Li, Qin Zou, Zhongpei Zhang, Jin Huang and Qingchun Deng

YTHDF2, a protein repressed by miR-145, regulates proliferation, apoptosis, and migration in ovarian cancer cells

RNA methylation can reverse the methylation modification at the RNA level, which is an extremely important epigenetic modification. The function and mechanism of YTHDF2, as a reader of m6A modification, in epi...

Authors: Jie Li, Lei Wu, Meili Pei and Yun Zhang

microRNA-1271-5p/TIAM1 suppresses the progression of ovarian cancer through inactivating Notch signaling pathway

Ovarian cancer (OC) has been regarded as the most malignant gynecological neoplasm and often confers grave outcomes owing to the frequent metastasis and high recurrence. A previous study has demonstrated that ...

Authors: Feng-Juan Han, Jia Li, Ying Shen, Ying Guo, Yi-Chao Liu, Yang Yu, Jia-Yue Xu, Shao-Xuan Liu and Yan-Hong Wang

Degenerated oocyte in the cohort adversely affects IVF outcome

The presence of Degenerated Oocyte (DEG) was mostly described after intracytoplasmic sperm injection (ICSI), with fewer reports on DEG at the time of ovum pick-up (OPU). This study aims to assess morphokinetic...

Authors: Yuval Atzmon, Mediea Michaeli, Diana Poltov, Nechami Rotfarb, Oshrit Lebovitz, Nardin Aslih and Einat Shalom-Paz

Effect of animal-sourced bioactive peptides on the in vitro development of mouse preantral follicles

The aim of this study was to investigate the effect of bioactive peptides (BAPT) from animal sources on the development of mouse preantral follicles in vitro. Preantral follicles were isolated and randomly div...

Authors: Gang Liu, Shubin Li, Jinyu Ren, Chunyu Wang, Yaxuan Zhang, Xiulan Su and Yanfeng Dai

High preoperative serum sVCAM-1 concentration as a predictor of early ovarian cancer recurrence

Authors: Marina Jakimovska, Katarina Černe, Ivan Verdenik and Borut Kobal

Troxerutin protects against DHT-induced polycystic ovary syndrome in rats

The exact pathogenesis of polycystic ovary syndrome (PCOS), the most common neuroendocrine disorder in women of reproductive age, has not been fully elucidated. Recent studies suggested that chronic inflammati...

Authors: Zixuan Gao, Xiaochen Ma, Jing Liu, Yuhang Ge, Lei Wang, Ping Fu, Zhian Liu, Ruiqin Yao and Xiaonan Yan

Impact of the COVID-19 epidemic at a high-volume facility in gynecological oncology in Tokyo, Japan: a single-center experience

The number of cases of novel coronavirus disease 2019 (COVID-19) in Japan have risen since the first case was reported on January 24, 2020, and 6225 infections have been reported as of June 30, 2020. On April ...

Authors: Yuya Nogami, Yusuke Kobayashi, Kosuke Tsuji, Megumi Yokota, Hiroshi Nishio, Masaru Nakamura, Wataru Yamagami, Tohru Morisada, Eiichiro Tominaga, Kouji Banno and Daisuke Aoki

Identification of circular RNAs in the ovarian follicles of Meishan and Duroc sows during the follicular phase

Circular RNAs (circRNAs) are a newly discovered class of endogenous non-coding RNAs that play an important role in growth and development by regulating gene expression and participating in a variety of biologi...

Authors: Su Xie, Mengxun Li, Yansen Chen, Yi Liu, Lipeng Ma, Xiaomei Sun, Yishan Sun, Ruonan Gao and Tao Huang

Can polymorphisms of AMH/AMHR2 affect ovarian stimulation outcomes? A systematic review and meta-analysis

Previous studies have investigated the effects of anti-Müllerian hormone (AMH) and AMH type II receptor (AMHR2) polymorphisms on ovarian stimulation outcomes, but the results were inconsistent.

Authors: Di Chen, Xiangyu Zhu and Jielei Wu

Rising serum CA-125 levels within the normal range is strongly associated recurrence risk and survival of ovarian cancer

In clinical practice alterations in CA-125 concentration within normal range in patients with ovarian cancer after first-line treatment are common. Even minor increase in CA-125 concentration is associated wit...

Authors: Szymon Piatek, Grzegorz Panek, Zbigniew Lewandowski, Mariusz Bidzinski, Dominika Piatek, Przemyslaw Kosinski and Miroslaw Wielgos

A real-world study on characteristics, treatments and outcomes in US patients with advanced stage ovarian cancer

Detailed epidemiologic descriptions of large populations of advanced stage ovarian cancer patients have been lacking to date. This study aimed to describe the patient characteristics, treatment patterns, survi...

Authors: Daniel C. Beachler, Francois-Xavier Lamy, Leo Russo, Devon H. Taylor, Jade Dinh, Ruihua Yin, Aziza Jamal-Allial, Samuel Dychter, Stephan Lanes and Patrice Verpillat

Knockdown of ribosomal protein S6 suppresses proliferation, migration, and invasion in epithelial ovarian cancer

Ovarian cancer typically is diagnosed late because insensitivity and lack of specificity of current biomarkers prior to its clinical detection. Ribosomal protein S6 (RPS6) is a ribosomal protein involved in th...

Authors: Xueqing Yang, Luxi Xu, Yu-e Yang, Chang Xiong, Jinjin Yu, Yuan Wang and Yaying Lin

miRNA expression profile changes in the peripheral blood of monozygotic discordant twins for epithelial ovarian carcinoma: potential new biomarkers for early diagnosis and prognosis of ovarian carcinoma

Ovarian cancer is the second most common gynecologic cancer with high mortality rate and generally diagnosed in advanced stages. The 5-year disease-free survival is below 40%. MicroRNAs, subset of the non-codi...

Authors: Seref Bugra Tuncer, Ozge Sukruoglu Erdogan, Seda Kilic Erciyas, Mukaddes Avsar Saral, Betul Celik, Demet Akdeniz Odemis, Gozde Kuru Turkcan and Hulya Yazici

Pannexin 1 inhibition delays maturation and improves development of Bos taurus oocytes

Intercellular exchange between the oocyte and its surrounding cells within the follicular environment is critical for oocyte maturation and subsequent development. In vertebrates this exchange is facilitated t...

Authors: Zachary Timothy Dye, Lauren Virginia Rutledge, Silvia Penuela and Paul William Dyce

The survival effect of ovary preservation in early stage endometrial cancer: a single institution retrospective analysis

We investigated the effect of ovary preserving surgery in early International Federation of Obstetrics and Gynecology (FIGO) stage endometrial cancer patients.

Authors: Wonkyo Shin, Sang-Yoon Park, Sokbom Kang, Myong Cheol Lim and Sang-Soo Seo

Telomere length in granulosa cells and leukocytes: a potential marker of female fertility? A systematic review of the literature

In the context of a continuously increased delay of motherhood and of an increase of the incidence of premature ovarian failure, it is of the greatest interest to dispose of a predictive marker of the duration...

Authors: Anne-Julie Fattet, Simon Toupance, Simon N. Thornton, Nicolas Monnin, Jean-Louis Guéant, Athanase Benetos and Isabelle Koscinski

Neoadjuvant metformin added to conventional chemotherapy synergizes anti-proliferative effects in ovarian cancer

Ovarian cancer is the leading cause of cancer-related death among women. Complete cytoreductive surgery followed by platinum-taxene chemotherapy has been the gold standard for a long time. Various compounds ha...

Authors: Kuo-Chang Wen, Pi-Lin Sung, Alexander T. H. Wu, Ping-Chieh Chou, Jun-Hung Lin, Chi-Ying F. Huang, Sai-Ching J. Yeung and Mong-Hong Lee

Initial ovarian sensitivity index predicts embryo quality and pregnancy potential in the first days of controlled ovarian stimulation

To determine if a modified ovarian sensitivity index (MOSI), based on initial follicular measurements and the initial follicle-stimulating hormone (FSH) dose, can predict the production of high-quality embryos...

Authors: David Camargo-Mattos, Uziel García, Felipe Camargo-Diaz, Ginna Ortiz, Ivan Madrazo and Esther Lopez-Bayghen

Transcriptomics of cumulus cells – a window into oocyte maturation in humans

Cumulus cells (CC) encapsulate growing oocytes and support their growth and development. Transcriptomic signatures of CC have the potential to serve as valuable non-invasive biomarkers for oocyte competency an...

Authors: Brandon A. Wyse, Noga Fuchs Weizman, Seth Kadish, Hanna Balakier, Mugundhine Sangaralingam and Clifford L. Librach

Tumor-suppressor miRNA-27b-5p regulates the growth and metastatic behaviors of ovarian carcinoma cells by targeting CXCL1

MicroRNAs (miRNAs) play crucial functions in the progression of ovarian cancer. MicroRNA-27b-5p (miR-27b-5p) has been identified as a cancer-associated miRNA. Nevertheless, the expression profile of miR-27b-5p...

Authors: Chun Hua Liu, Xue Ning Jing, Xiao Lan Liu, Shan Yong Qin, Min Wei Liu and Chun Hong Hou

Chemotherapy is not necessary for early-stage serous and endometrioid ovarian cancer after undergoing comprehensive staging surgery

In order to investigate whether adjuvant chemotherapy is essential for patients with early-stage serous and endometrioid epithelial ovarian cancer, the present study collected data from the US Surveillance, Ep...

Authors: Shuqing Li and Zhiling Zhu

MiR-23a induced the activation of CDC42/PAK1 pathway and cell cycle arrest in human cov434 cells by targeting FGD4

MiRNAs play important roles in the development of ovarian cancer, activation of primitive follicles, follicular development, oocyte maturation and ovulation. In the present study, we investigated the specific ...

Authors: Ji Lin, Huijuan Huang, Liheng Lin, Weiwei Li and Jianfen Huang

Serum D-dimer, albumin and systemic inflammatory response markers in ovarian clear cell carcinoma and their prognostic implications

This study attempts to evaluate whether preoperative systemic inflammatory response (SIR) markers or other hematological variables, such as albumin, D-dimer, and carbohydrate antigen 125, play roles in predict...

Authors: Wei Chen, Siyuan Zhong, Boer Shan, Shuling Zhou, Xiaohua Wu, Huijuan Yang and Shuang Ye

Assisted hatching of vitrified-warmed blastocysts prior to embryo transfer does not improve pregnancy outcomes

This study aims to determine the impact of assisted hatching (AH) on pregnancy outcomes in vitrified-warmed blastocyst transfers, and evaluate if embryo expansion or morphology influences outcomes.

Authors: Charis Ng, Marta Wais, Taryn Nichols, Sarah Garrow, Julius Hreinsson, Zhong-Cheng Luo and Crystal Chan

Follicular phase length has no influence on frozen-thawed embryo transfers in natural cycles

Whether menstrual variability in women with regular and ovulatory cycle could affect embryo implantation remains controversial, with conflicting evidences presented in the literature. Thus, in this study, we e...

Authors: Ying Ying, Fuman Qiu, Qing Huang, Sichen Li, Haiying Liu and Jianqiao Liu

Expression of metalloproteinases MMP-2 and MMP-9 is associated to the presence of androgen receptor in epithelial ovarian tumors

The current study evaluated the metalloproteinases MMP-2 and MMP-9 expression in epithelial cells and the surrounding stroma in ovarian tumors and the association of MMPs with the histological subtypes, the cl...

Authors: Flavia Morales-Vásquez, Rocío Castillo-Sánchez, María J. Gómora, Miguel Ángel Almaraz, Enrique Pedernera, Delia Pérez-Montiel, Elizabeth Rendón, Horacio Noé López-Basave, Edgar Román-Basaure, Sergio Cuevas-Covarrubias, Juan Maldonado-Cubas, Antonio Villa and Carmen Mendez

WISP2 promotes cell proliferation via targeting ERK and YAP in ovarian cancer cells

Wnt-inducible signaling pathway protein 2 (WISP2) is a wnt1-induced signaling pathway protein 2. Although studies indicate that WISP2 may promote the development of various tumors, its role in ovarian cancer r...

Authors: Zi-Qing Shi, Zi-Yan Chen, Yao Han, Heng-Yan Zhu, Meng-Dan Lyu, Han Zhang, Yi Zhang, Liu-Qing Yang and Wei-Wei Pan

LncRNA CTBP1-AS2 regulates miR-216a/ PTEN to suppress ovarian cancer cell proliferation

We analyzed TCGA dataset and observed the downregulation of CTBP1-AS2 in ovarian cancer (OC), while the function of CTBP1-AS2 has only been investigated in diabetes and cardiomyocyte hypertrophy, but not in ca...

Authors: Kaiying Cui and Genhai Zhu

Anti-proliferative activities of Byrsocarpus coccineus Schum. and Thonn. (Connaraceae) using ovarian cancer cell lines

Ovarian cancer (OvCa) is one of the most lethal tumors of gynecologic malignancies, due to lack of early detection, and a high rate of metastasis. The standard treatment for OvCa is surgery and cytotoxic chemo...

Authors: Caroline E. Ukwade, Osaretin A. T. Ebuehi, Rahmat A. Adisa, Santosh K. Singh and Rajesh Singh

Bioinformatics analysis of gene expression profile of serous ovarian carcinomas to screen key genes and pathways

Serous ovarian carcinomas (SCA) are the most common and most aggressive ovarian carcinoma subtype which etiology remains unclear. To investigate the prospective role of mRNAs in the tumorigenesis and progressi...

Authors: Hongjun Fei, Songchang Chen and Chenming Xu

circRNA-UBAP2 promotes the proliferation and inhibits apoptosis of ovarian cancer though miR-382-5p/PRPF8 axis

circular RNAs (circRNAs) have been reported to be essential regulators of multiple malignant cancers. However, the functions of circRNAs in ovarian cancer need to be further explored. The aim of our study is t...

Authors: Qin Xu, Bo Deng, Manlin Li, Yang Chen and Li Zhuan

Salpingectomy may decrease antral follicle count but not live birth rate for IVF-ET patients aged 35–39 years: a retrospective study

Problems with fallopian tubes are one of the main reasons for women to undergo in vitro fertilization-embryo transfer (IVF-ET). A large proportion of women with ectopic pregnancy, fallopian tube obstruction an...

Authors: Tong Chen, Feiyan Zhao, Qin Wang, Chang Liu, Yonglian Lan, Shuyu Wang, Zhimin Xin and Xiaokui Yang

Withaferin A: a potential therapeutic agent against COVID-19 infection

The outbreak and continued spread of the novel coronavirus disease 2019 (COVID-19) is a preeminent global health threat that has resulted in the infection of over 11.5 million people worldwide. In addition, th...

Authors: Alex R. Straughn and Sham S. Kakar

Platelet count as a biomarker for monitoring treatment response and disease recurrence in recurrent epithelial ovarian cancer

We sought to determine the impact of pretreatment plasma platelet levels, dimerized plasmin fragment (D-dimer) and fibrinogen in recurrent epithelial ovarian cancer (EOC) and the impact of platelet levels on S...

Authors: Qinghong Hu, Abha Hada and Liping Han