Articles

Defining a murine ovarian cancer model for the evaluation of conditionally-replicative adenovirus (CRAd) virotherapy agents

Virotherapy represents a promising approach for ovarian cancer. In this regard, conditionally replicative adenovirus (CRAd) has been translated to the context of human clinical trials. Advanced design of CRAds...

Authors: Rebeca González-Pastor, Ahmad Mohammad Ashshi, Adel Galal El-Shemi, Igor P. Dmitriev, Elena A. Kashentseva, Zhi Hong Lu, S. Peter Goedegebuure, Osvaldo L. Podhajcer and David T. Curiel

TOP2A as marker of response to pegylated lyposomal doxorubicin (PLD) in epithelial ovarian cancers

Relapsed epithelial ovarian cancer (EOC) is frequently treated with pegylated liposomal doxorubicin (PLD). Unfortunately, most patients do not benefit from treatment. Prediction of response is crucial to optim...

Authors: Eleonora Ghisoni, Furio Maggiorotto, Fulvio Borella, Gloria Mittica, Sofia Genta, Gaia Giannone, Dionyssios Katsaros, Alberto Sciarrillo, Annamaria Ferrero, Ivana Sarotto, Jessica Erriquez, Maria Flavia Di Renzo, Massimo Aglietta and Giorgio Valabrega

Can complete blood count inflammatory parameters in epithelial ovarian cancer contribute to prognosis? - a survival analysis

The aim of the present study was to investigate the prognostic significance of preoperative complete blood count inflammatory markers in women operated for invasive Epithelial Ovarian Cancer (EOC).

Authors: Mehmet Ufuk Ceran, Umit Tasdemir, Eser Colak and Tayfun Güngör

Progesterone reduces cell survival in primary cultures of endometrioid ovarian cancer

Ovarian cancer is the most lethal of all gynecologic malignancies. The relationship between sexual steroids receptors and ovarian cancer progression has been largely evaluated. The presence of progesterone rec...

Authors: Enrique Pedernera, María J. Gómora, Flavia Morales-Vásquez, Delia Pérez-Montiel and Carmen Mendez

Aberrant DNA methylation suppresses expression of estrogen receptor 1 (ESR1) in ovarian endometrioma

In ovarian endometriomas (OE), the expression statuses of various steroid hormone receptors are altered compared with their expression statuses in eutopic endometrium (EE). For example, in OE, the expressions ...

Authors: Ryo Maekawa, Yumiko Mihara, Shun Sato, Maki Okada, Isao Tamura, Masahiro Shinagawa, Yuichiro Shirafuta, Haruka Takagi, Toshiaki Taketani, Hiroshi Tamura and Norihiro Sugino

Syzygium cumini (L.) Skeels improves metabolic and ovarian parameters in female obese rats with malfunctioning hypothalamus-pituitary-gonadal axis

Obesity is a chronic and multifactorial disease characterized by increased adipose tissue. In females, obesity leads to reduced ovulation and lower chances of conception in diseases like polycystic ovary syndr...

Authors: R. O. A. Benevides, C. C. Vale, J. L. L. Fontelles, L. M. França, T. S. Teófilo, S. N. Silva, A. M. A. Paes and R. S. Gaspar

The ability of whole-body SUVmax in F-18 FDG PET/CT to predict suboptimal cytoreduction during primary debulking surgery for advanced ovarian cancer

The aim of this study was to (1) evaluate the ability of F-18 fluorodeoxyglucose positron emission tomography/computed tomography (FDG PET/CT) parameters to predict suboptimal cytoreduction and (2) to create a...

Authors: Gun Oh. Chong, Shin Young Jeong, Yoon Hee Lee, Hyun Jung Lee, Sang-Woo Lee, Hyung Soo Han, Dae Gy Hong and Yoon Soon Lee

Comparison and analysis of the clinicopathological features of SCEO and ECOM

The aim of our study was to evaluate and compare the differences in the clinicopathological variables and overall survival (OS) of synchronous primary cancers of the endometrium and ovary (SCEO) and endometria...

Authors: Ting Wang, Xiaodan Zhang, Zhiying Lu, Junyan Wang and Keqin Hua

Correction to: Nanog interaction with the androgen receptor signaling axis induce ovarian cancer stem cell regulation: studies based on the CRISPR/Cas9 system

Abstract

Authors: Kaijian Ling, Lupin Jiang, Shi Liang, Joseph Kwong, Leiyan Yang, Yudi Li, PingYin, Qingchun Deng and Zhiqing Liang

Current strategies for the targeted treatment of high-grade serous epithelial ovarian cancer and relevance of BRCA mutational status

Epithelial ovarian cancer is the most lethal gynecologic malignancy. In most women, it is diagnosed at an advanced stage, which largely explains the poor prognosis of this malignancy. Germline mutations of the...

Authors: Angiolo Gadducci, Valentina Guarneri, Fedro Alessandro Peccatori, Graziana Ronzino, Giuseppa Scandurra, Claudio Zamagni, Paolo Zola and Vanda Salutari

Low dose human chorionic gonadotropin administration at the time of gonadotropin releasing-hormone agonist trigger versus 35 h later in women at high risk of developing ovarian hyperstimulation syndrome – a prospective randomized double-blind clinical trial

Ovarian hyperstimulation syndrome remains a serious complication during in vitro fertilization cycles if high dose human chorionic gonadotropin (hCG) is used to trigger ovulation in high responder patients. Th...

Authors: L. L. Engmann, B. S. Maslow, L. A. Kaye, D. W. Griffin, A. J. DiLuigi, D. W. Schmidt, D. R. Grow, J. C. Nulsen and C. A. Benadiva

Association of the hypoxia-inducible factor-1α (HIF-1α) gene polymorphisms with prognosis in ovarian clear cell carcinoma

Ovarian clear cell carcinoma (OCCC) is the second most common ovarian cancer after serous carcinoma in Japan. OCCC has a more unfavorable clinical outcome due to a poor response to platinum-based chemotherapy,...

Authors: Hiroyuki Suzuki, Mitsutake Yano, Mariko Miyazawa, Masaki Miyazawa, Naoki Ogane, Kosei Hasegawa, Hitoshi Tsuda, Masayuki Yoshida, Ryugo Okagaki, Osamu Ishihara and Masanori Yasuda

Upregulated expression of serum exosomal miR-375 and miR-1307 enhance the diagnostic power of CA125 for ovarian cancer

Ovarian cancer (OC) is associated with high mortality in gynecological oncology; this is mainly due to the low diagnosis rate. Exosomal miRNA has demonstrated potential as a tumor biomarker. We aimed to explor...

Authors: Ying Ying Su, Li Sun, Zhi Rui Guo, Jin Chang Li, Ting Ting Bai, Xiao Xiao Cai, Wen Han Li and Ye Fei Zhu

Vitamin D and probiotic co-supplementation affects mental health, hormonal, inflammatory and oxidative stress parameters in women with polycystic ovary syndrome

The aim of this study was to determine the effect of vitamin D and probiotic co-administration on mental health, hormonal, inflammatory and oxidative stress parameters in women with polycystic ovary syndrome (...

Authors: Vahidreza Ostadmohammadi, Mehri Jamilian, Fereshteh Bahmani and Zatollah Asemi

Overexpression of CCDC69 activates p14^ARF/MDM2/p53 pathway and confers cisplatin sensitivity

The aim of the study is to explore the relationship between CCDC69 expression and resistance of ovarian cancer cells to cisplatin and reveal the underlying mechanism.

Authors: Long Cui, Fang Zhou, Cui Chen and Chi Chiu Wang

The role of the endocannabinoid system in female reproductive tissues

There has been increasing interest in the role of endocannabinoids as critical modulators of the female reproductive processes. Endocannabinoids are natural ligands of cannabinoid, vanilloid, and peroxisome pr...

Authors: O’Llenecia S. Walker, Alison C. Holloway and Sandeep Raha

Recurrent ovarian mixed germ cell tumor with unusual malignant transformation: a case report

The value of this report is the identification of late recurrence with an extremely unusual combination of malignant transformation. In particular, the retroconversion of immature to mature teratoma as well as...

Authors: Yi-Le Lee, Chiung-Ru Lai and Ming-Shyen Yen

Cancer-testis antigens in ovarian cancer: implication for biomarkers and therapeutic targets

Ovarian cancer remains the most fatal gynecologic malignancy worldwide due to delayed diagnosis as well as recurrence and drug resistance. Thus, the development of new tumor-related molecules with high sensiti...

Authors: Kaipeng Xie, Chenyang Fu, Suli Wang, Hanzi Xu, Siyu Liu, Yang Shao, Zhen Gong, Xiaoli Wu, Bo Xu, Jing Han, Juan Xu, Pengfei Xu, Xuemei Jia and Jiangping Wu

Diversity of imaging features of ovarian sclerosing stromal tumors on MRI and PET-CT: a case report and literature review

Sclerosing stromal tumors (SST) are rare, benign tumors classified as sex cord stromal tumors. To our knowledge, positron emission tomography with computed tomography (PET-CT) findings of SST have only been de...

Authors: Hiroki Matsutani, Go Nakai, Takashi Yamada, Kazuhiro Yamamoto, Masahide Ohmichi and Yoshifumi Narumi

Rapidly growing juvenile granulosa cell tumor of the ovary arising in adult: a case report and review of the literature

Ovarian granulosa cell tumors (GCTs) are divided into adult GCT (AGCT) and juvenile GCT (JGCT). The AGCT is more common type, conversely, less than 5% of tumors are the JGCT and occur in mainly premenarchal gi...

Authors: Yuki Inada, Go Nakai, Kazuhiro Yamamoto, Takashi Yamada, Yoshinobu Hirose, Yoshito Terai, Masahide Ohmichi and Yoshifumi Narumi

Protective role of Ficus deltoidea against BPA-induced impairments of the follicular development, estrous cycle, gonadotropin and sex steroid hormones level of prepubertal rats

Ficus deltoidea is one of the well-known medicinal plants in Malaysia that is traditionally used by the Malay community to treat various ailments and for maintenance of female reproductive health. The objective o...

Authors: Siti Sarah Mohamad Zaid, Shatrah Othman and Normadiah M. Kassim

Expression of Concern to: Does ovary need D-chiro-inositol?

Authors: Rosalbino Isabella and Emanuela Raffone

Isolated ovarian tuberculosis in an Immuno- competent woman in the post partum period: case report

Pelvic tuberculosis is a rare form of extrapulmonary tuberculosis. It commonly involves the fallopian tubes and the uterus from a lympho-hematogeneous spread. The presentation of pelvic tuberculosis as an isol...

Authors: Wondimu Gudu

Is the aging human ovary still ticking?: Expression of clock-genes in luteinized granulosa cells of young and older women

It has been shown – mostly in animal models - that circadian clock genes are expressed in granulosa cells and in corpora luteum and might be essential for the ovulatory process and steroidogenesis.

Authors: Amnon Brzezinski, A. Saada, H. Miller, NA Brzezinski-Sinai and A. Ben-Meir

Decrease in preovulatory serum estradiol is a valuable marker for predicting premature ovulation in natural/unstimulated in vitro fertilization cycle

Premature ovulation occurs at a high rate in natural-cycle in vitro fertilization (IVF), and cycle cancellation further hampers the overall efficiency of the procedure. While lower levels of estradiol (E2) are...

Authors: Xuefeng Lu, Shuzin Khor, Qianqian Zhu, Lihua Sun, Yun Wang, Qiuju Chen, Ling Wu, Yonglun Fu, Hui Tian, Qifeng Lyu, Renfei Cai and Yanping Kuang

Identification of core genes in ovarian cancer by an integrative meta-analysis

Epithelial ovarian cancer is one of the most severe public health threats in women. Since it is still challenging to screen in early stages, identification of core genes that play an essential role in epithel...

Authors: Wenyu Li, Zheran Liu, Bowen Liang, Siyang Chen, Xinping Zhang, Xiaoqin Tong, Weiming Lou, Lulu Le, Xiaoli Tang and Fen Fu

Luteolin sensitizes the antitumor effect of cisplatin in drug-resistant ovarian cancer via induction of apoptosis and inhibition of cell migration and invasion

Luteolin, a polyphenolic flavone, has been demonstrated to exert anti-tumor activity in various cancer types. Cisplatin drug resistance is a major obstacle in the management of ovarian cancer. In the present s...

Authors: Haixia Wang, Youjun Luo, Tiankui Qiao, Zhaoxia Wu and Zhonghua Huang

Diagnostic value of the gynecology imaging reporting and data system (GI-RADS) with the ovarian malignancy marker CA-125 in preoperative adnexal tumor assessment

The purpose of this study is to assess the preoperative evaluation of an adnexal mass using the GI-RADS classification and to verify whether CA-125 measurement can offer any additional benefits to the GI-RADS-...

Authors: Michal Migda, Migda Bartosz, Marian S. Migda, Marcin Kierszk, Gieryn Katarzyna and Marek Maleńczyk

Comparison of stage III mucinous and serous ovarian cancer: a case-control study

The purpose of this case-control study was to compare the prognoses of women with stage III mucinous ovarian carcinoma (MOC) who received maximal or optimal cytoreduction followed by paclitaxel plus carboplati...

Authors: Zeliha Firat Cuylan, Emine Karabuk, Murat OZ, Ahmet Taner Turan, Mehmet M. Meydanli, Salih Taskin, Mustafa Erkan Sari, Hanifi Sahin, Suat C. Ulukent, Ozgur Akbayir, Kemal Gungorduk, Tayfun Gungor, Mehmet F. Kose and Ali Ayhan

DAXX promotes ovarian cancer ascites cell proliferation and migration by activating the ERK signaling pathway

The death-domain-associated protein (DAXX) was originally identified as a protein that binds to the transmembrane death receptor FAS and enhances both FAS-induced and transforming growth factor-β-dependent apo...

Authors: Sheng-Bing Liu, Xue-Ping Lin, Ying Xu, Zhong-Fei Shen and Wei-Wei Pan

Mitochondrial membrane depolarization enhances TRAIL-induced cell death in adult human granulosa tumor cells, KGN, through inhibition of BIRC5

Cellular metabolic changes that accompany malignant transformation have been heralded as hallmark features of cancer. However, metabolic signatures between neoplasms can be unique, allowing for distinctions in...

Authors: Julie A. MacDonald, Niharika Kura, Carleigh Sussman and Dori C. Woods

Mass spectrometry-based proteomics techniques and their application in ovarian cancer research

Ovarian cancer has emerged as one of the leading cause of gynecological malignancies. So far, the measurement of CA125 and HE4 concentrations in blood and transvaginal ultrasound examination are essential ovar...

Authors: Agata Swiatly, Szymon Plewa, Jan Matysiak and Zenon J. Kokot

Intrafollicular fibroblast growth factor 13 in polycystic ovary syndrome: relationship with androgen levels and oocyte developmental competence

Fibroblast growth factor 13 (FGF13) is one of the most highly expressed FGF family members in adult mouse ovary. However, its precise roles in ovarian function remain largely unknown. We sought to evaluate the...

Authors: Yu Liu, Shengxian Li, Tao Tao, Xiaoxue Li, Qinling Zhu, Yu Liao, Jing Ma, Yun Sun and Wei Liu

CT of ovarian cancer: 3D cinematic rendering for preoperative evaluation

Ovarian cancer is the second most common gynecologic malignancy. As the primary imaging modality, computed tomography (CT) can provide staging information for preoperative planning and determination of surgica...

Authors: Yi-ren Jin, Xie-lan Yang, Qin-qing Li, Zhi-ling Yan, Hong-ying Yang and Chengde Liao

Prognostic value of various subtypes of extracellular DNA in ovarian cancer patients

Patients with ovarian cancer represent a heterogeneous population with a variable prognosis and response to chemotherapy. Plasma DNA has been shown to have a prognostic value in different types of cancer inclu...

Authors: Katarina Kalavska, Tomas Minarik, Barbora Vlkova, Denisa Manasova, Michaela Kubickova, Andrej Jurik, Jozef Mardiak, Jozef Sufliarsky, Peter Celec and Michal Mego

Assessment of Prostaglandin-Endoperoxide Synthase 2 and Versican gene expression profile from the cumulus cells: association with better in vitro fertilization outcomes

Current methods for determining superior embryo quality (morphological assessment) are unable to compensate for poor pregnancy outcomes. Due to the importance of the cumulus-oocyte complex and the value of cum...

Authors: Azucena Ocampo, Jeimy Pedraza, Ginna Ortiz, Elizabeth Hernández-Pérez, Leonardo Porchia and Esther López-Bayghen

Gonadotropin and steroid hormones regulate pluripotent very small embryonic-like stem cells in adult mouse uterine endometrium

Very small embryonic-like stem cells (VSELs) exist in adult organs, express pluripotent markers and have the ability to differentiate into three germ layers in vitro. Testicular, ovarian and hematopoietic stem/pr...

Authors: Kreema James, Deepa Bhartiya, Ranita Ganguly, Ankita Kaushik, Kavita Gala, Pushpa Singh and S. M. Metkari

Non-classical 11β-hydroxylase deficiency caused by compound heterozygous mutations: a case study and literature review

11β-hydroxylase deficiency (11OHD) is extremely rare, and reports of non-classical 11OHD are even rarer. Non-classical 11OHD usually presents as premature adrenarche, hyperandrogenism, menstrual disorders, and...

Authors: Dongdong Wang, Jiahui Wang, Tong Tong and Qing Yang

Exosomal miR-1290 is a potential biomarker of high-grade serous ovarian carcinoma and can discriminate patients from those with malignancies of other histological types

microRNAs (miRNAs) stably exist in circulating blood encapsulated in extracellular vesicles such as exosomes; therefore, serum miRNAs have the potential to serve as novel cancer biomarkers. New diagnostic mark...

Authors: Masaki Kobayashi, Kenjiro Sawada, Koji Nakamura, Akihiko Yoshimura, Mayuko Miyamoto, Aasa Shimizu, Kyoso Ishida, Erika Nakatsuka, Michiko Kodama, Kae Hashimoto, Seiji Mabuchi and Tadashi Kimura

The effects of probiotic and selenium co-supplementation on parameters of mental health, hormonal profiles, and biomarkers of inflammation and oxidative stress in women with polycystic ovary syndrome

The aim of this study was to evaluate the effect of the co-administration of probiotic and selenium on parameters of mental health, hormonal profiles, and biomarkers of inflammation and oxidative stress in wom...

Authors: Mehri Jamilian, Shirin Mansury, Fereshteh Bahmani, Zahra Heidar, Elaheh Amirani and Zatollah Asemi

Persistent megalocystic ovaries after ovarian hyperstimulation syndrome in a postpartum patient with polycystic ovarian syndrome: a case report

Ovary enlargement is common in controlled ovarian stimulation, which could continue several months during a successful pregnancy. However, persistent megalocystic ovaries 3 years after ovarian hyperstimulation...

Authors: Jinghua Shi, Xinyu Ren, Qinjie Tian, Aijun Sun and Rong Chen

Does a poor-quality embryo have an adverse impact on a good-quality embryo when transferred together?

In some in vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI) cycles, we may consider transferring one poor-quality embryo with one good-quality embryo. Previous studies have indicated that t...

Authors: Jiaheng Li, Mingze Du, Zhan Zhang, Yichun Guan, Xingling Wang, Xiao Zhang, Jing Liu, Zhouhui Pan, Bijun Wang and Wenxia Liu

Anaplastic carcinoma in ovarian seromucinous cystic tumor of borderline malignancy

The mortality rate of ovarian cancer is the highest among all gynecological malignancies in Japan. Ovarian tumors are classified as benign, borderline malignant, or malignant. Anticipating the histological sub...

Authors: Toshiyuki Okumura, Etuo Muronosono, Masahiko Tsubuku, Yasuhisa Terao, Satoru Takeda and Masanori Maruyama

Pregnancy after drug-free in vitro activation of follicles and fresh tissue autotransplantation in primary ovarian insufficiency patient: a case report and literature review

The aim of this report was to describe a case of pregnancy after drug-free in vitro activation (IVA) of follicles and fresh tissue autotransplantation in primary ovarian insufficiency (POI) patient and to revi...

Authors: F. Fabregues, J. Ferreri, J.M. Calafell, V. Moreno, A. Borrás, D. Manau and F. Carmona

Use of a Small Animal Radiation Research Platform (SARRP) facilitates analysis of systemic versus targeted radiation effects in the mouse ovary

Radiation exposure is known to cause accelerated aging and damage to the ovary, but the contribution of indirect versus direct effects is not well understood. We used the Small Animal Radiation Research Platfo...

Authors: Allison R. Grover, Bruce F. Kimler and Francesca E. Duncan

A case of ovarian clear cell carcinoma arising from ovarian mature cystic teratoma

It is well known that ovarian mature cystic teratomas (MCTs) occasionally go through malignant transformations. Among these, approximately 75% of histological types are squamous cell carcinoma, with the other ...

Authors: Kazuya Maeda, Yoshito Terai, Shinichi Terada, Hiroshi Maruoka, Yuhei Kogata, Keisuke Ashihara, Yoshimichi Tanaka, Tomohito Tanaka, Hiroshi Sasaki, Satoshi Tsunetoh, Takashi Yamada and Masahide Ohmichi

Ovarian teratoma in children: a plea for collaborative clinical study

Although teratomas are the most common histologic subtype of childhood ovarian germ cell tumors, their appropriate treatment in this age group still remains unclear. Paucity of research dedicated exclusively t...

Authors: Justyna Łuczak and Maciej Bagłaj

The value of MRI for differentiating benign from malignant sex cord-stromal tumors of the ovary: emphasis on diffusion-weighted MR imaging

To investigate MRI for differentiating benign from malignant sex cord-stromal tumors of the ovary (SCSTs) emphasizing on the value of diffusion-weighted (DW) magnetic resonance (MR) imaging.

Authors: Shu-Hui Zhao, Hai-Ming Li, Jin-Wei Qiang, Deng-Bin Wang and Hua Fan

The role of vitamin D in ovarian cancer: epidemiology, molecular mechanism and prevention

Vitamin D is a fat-soluble prohormone best known for its role in maintaining calcium homeostasis. Large numbers of epidemiological studies have shown that vitamin D plays an important role in cancer prevention...

Authors: Hui Guo, Jing Guo, Wenli Xie, Lingqin Yuan and Xiugui Sheng

Live birth rate after human chorionic gonadotropin priming in vitro maturation in women with polycystic ovary syndrome

In vitro maturation (IVM) has some advantages over conventional in vitro fertilization (IVF), particularly in polycystic ovary syndrome (PCOS) where the risk of ovarian hyperstimulation is high. We studied the...

Authors: V. N. A. Ho, T. D. Pham, A. H. Le, T. M. Ho and L. N. Vuong