Articles

Whole-exome sequencing in patients with premature ovarian insufficiency: early detection and early intervention

The loss of ovarian function in women, referred to as premature ovarian insufficiency (POI), is associated with a series of concomitant diseases. POI is genetically heterogeneous, and in most cases, the etiolo...

Authors: Hongli Liu, Xiaoli Wei, Yanwei Sha, Wensheng Liu, Haijie Gao, Jin Lin, Youzhu Li, Yaling Tang, Yifeng Wang, Yanlong Wang and Zhiying Su

The role of apatinib combined with paclitaxel (aluminum binding type) in platinum-resistant ovarian cancer

To assess the anti-tumor activity and side effects of different dosages of paclitaxel (albumin binding type) (hereinafter referred to as nab-P) combined with Apatinib (hereinafter referred to as AP) in platinu...

Authors: Hong Zhao, Rong Li, Xiaoyan Wang, Xin Lu, Min Hu, Jinbin Zhang, Xia Zhao, Xiaoqin Song and Yangyang Liu

A novel signature of two long non-coding RNAs in BRCA mutant ovarian cancer to predict prognosis and efficiency of chemotherapy

In this study we aimed to identify a prognostic signature in BRCA1/2 mutations to predict disease progression and the efficiency of chemotherapy ovarian cancer (OV), the second most common cause of death from gyn...

Authors: Yinglian Pan, Li Ping Jia, Yuzhu Liu, Yiyu Han, Qian Li, Qin Zou, Zhongpei Zhang, Jin Huang and Qingchun Deng

YTHDF2, a protein repressed by miR-145, regulates proliferation, apoptosis, and migration in ovarian cancer cells

RNA methylation can reverse the methylation modification at the RNA level, which is an extremely important epigenetic modification. The function and mechanism of YTHDF2, as a reader of m6A modification, in epi...

Authors: Jie Li, Lei Wu, Meili Pei and Yun Zhang

microRNA-1271-5p/TIAM1 suppresses the progression of ovarian cancer through inactivating Notch signaling pathway

Ovarian cancer (OC) has been regarded as the most malignant gynecological neoplasm and often confers grave outcomes owing to the frequent metastasis and high recurrence. A previous study has demonstrated that ...

Authors: Feng-Juan Han, Jia Li, Ying Shen, Ying Guo, Yi-Chao Liu, Yang Yu, Jia-Yue Xu, Shao-Xuan Liu and Yan-Hong Wang

Degenerated oocyte in the cohort adversely affects IVF outcome

The presence of Degenerated Oocyte (DEG) was mostly described after intracytoplasmic sperm injection (ICSI), with fewer reports on DEG at the time of ovum pick-up (OPU). This study aims to assess morphokinetic...

Authors: Yuval Atzmon, Mediea Michaeli, Diana Poltov, Nechami Rotfarb, Oshrit Lebovitz, Nardin Aslih and Einat Shalom-Paz

Effect of animal-sourced bioactive peptides on the in vitro development of mouse preantral follicles

The aim of this study was to investigate the effect of bioactive peptides (BAPT) from animal sources on the development of mouse preantral follicles in vitro. Preantral follicles were isolated and randomly div...

Authors: Gang Liu, Shubin Li, Jinyu Ren, Chunyu Wang, Yaxuan Zhang, Xiulan Su and Yanfeng Dai

High preoperative serum sVCAM-1 concentration as a predictor of early ovarian cancer recurrence

Authors: Marina Jakimovska, Katarina Černe, Ivan Verdenik and Borut Kobal

Troxerutin protects against DHT-induced polycystic ovary syndrome in rats

The exact pathogenesis of polycystic ovary syndrome (PCOS), the most common neuroendocrine disorder in women of reproductive age, has not been fully elucidated. Recent studies suggested that chronic inflammati...

Authors: Zixuan Gao, Xiaochen Ma, Jing Liu, Yuhang Ge, Lei Wang, Ping Fu, Zhian Liu, Ruiqin Yao and Xiaonan Yan

Impact of the COVID-19 epidemic at a high-volume facility in gynecological oncology in Tokyo, Japan: a single-center experience

The number of cases of novel coronavirus disease 2019 (COVID-19) in Japan have risen since the first case was reported on January 24, 2020, and 6225 infections have been reported as of June 30, 2020. On April ...

Authors: Yuya Nogami, Yusuke Kobayashi, Kosuke Tsuji, Megumi Yokota, Hiroshi Nishio, Masaru Nakamura, Wataru Yamagami, Tohru Morisada, Eiichiro Tominaga, Kouji Banno and Daisuke Aoki

Identification of circular RNAs in the ovarian follicles of Meishan and Duroc sows during the follicular phase

Circular RNAs (circRNAs) are a newly discovered class of endogenous non-coding RNAs that play an important role in growth and development by regulating gene expression and participating in a variety of biologi...

Authors: Su Xie, Mengxun Li, Yansen Chen, Yi Liu, Lipeng Ma, Xiaomei Sun, Yishan Sun, Ruonan Gao and Tao Huang

Can polymorphisms of AMH/AMHR2 affect ovarian stimulation outcomes? A systematic review and meta-analysis

Previous studies have investigated the effects of anti-Müllerian hormone (AMH) and AMH type II receptor (AMHR2) polymorphisms on ovarian stimulation outcomes, but the results were inconsistent.

Authors: Di Chen, Xiangyu Zhu and Jielei Wu

Rising serum CA-125 levels within the normal range is strongly associated recurrence risk and survival of ovarian cancer

In clinical practice alterations in CA-125 concentration within normal range in patients with ovarian cancer after first-line treatment are common. Even minor increase in CA-125 concentration is associated wit...

Authors: Szymon Piatek, Grzegorz Panek, Zbigniew Lewandowski, Mariusz Bidzinski, Dominika Piatek, Przemyslaw Kosinski and Miroslaw Wielgos

A real-world study on characteristics, treatments and outcomes in US patients with advanced stage ovarian cancer

Detailed epidemiologic descriptions of large populations of advanced stage ovarian cancer patients have been lacking to date. This study aimed to describe the patient characteristics, treatment patterns, survi...

Authors: Daniel C. Beachler, Francois-Xavier Lamy, Leo Russo, Devon H. Taylor, Jade Dinh, Ruihua Yin, Aziza Jamal-Allial, Samuel Dychter, Stephan Lanes and Patrice Verpillat

Knockdown of ribosomal protein S6 suppresses proliferation, migration, and invasion in epithelial ovarian cancer

Ovarian cancer typically is diagnosed late because insensitivity and lack of specificity of current biomarkers prior to its clinical detection. Ribosomal protein S6 (RPS6) is a ribosomal protein involved in th...

Authors: Xueqing Yang, Luxi Xu, Yu-e Yang, Chang Xiong, Jinjin Yu, Yuan Wang and Yaying Lin

miRNA expression profile changes in the peripheral blood of monozygotic discordant twins for epithelial ovarian carcinoma: potential new biomarkers for early diagnosis and prognosis of ovarian carcinoma

Ovarian cancer is the second most common gynecologic cancer with high mortality rate and generally diagnosed in advanced stages. The 5-year disease-free survival is below 40%. MicroRNAs, subset of the non-codi...

Authors: Seref Bugra Tuncer, Ozge Sukruoglu Erdogan, Seda Kilic Erciyas, Mukaddes Avsar Saral, Betul Celik, Demet Akdeniz Odemis, Gozde Kuru Turkcan and Hulya Yazici

Pannexin 1 inhibition delays maturation and improves development of Bos taurus oocytes

Intercellular exchange between the oocyte and its surrounding cells within the follicular environment is critical for oocyte maturation and subsequent development. In vertebrates this exchange is facilitated t...

Authors: Zachary Timothy Dye, Lauren Virginia Rutledge, Silvia Penuela and Paul William Dyce

The survival effect of ovary preservation in early stage endometrial cancer: a single institution retrospective analysis

We investigated the effect of ovary preserving surgery in early International Federation of Obstetrics and Gynecology (FIGO) stage endometrial cancer patients.

Authors: Wonkyo Shin, Sang-Yoon Park, Sokbom Kang, Myong Cheol Lim and Sang-Soo Seo

Telomere length in granulosa cells and leukocytes: a potential marker of female fertility? A systematic review of the literature

In the context of a continuously increased delay of motherhood and of an increase of the incidence of premature ovarian failure, it is of the greatest interest to dispose of a predictive marker of the duration...

Authors: Anne-Julie Fattet, Simon Toupance, Simon N. Thornton, Nicolas Monnin, Jean-Louis Guéant, Athanase Benetos and Isabelle Koscinski

Neoadjuvant metformin added to conventional chemotherapy synergizes anti-proliferative effects in ovarian cancer

Ovarian cancer is the leading cause of cancer-related death among women. Complete cytoreductive surgery followed by platinum-taxene chemotherapy has been the gold standard for a long time. Various compounds ha...

Authors: Kuo-Chang Wen, Pi-Lin Sung, Alexander T. H. Wu, Ping-Chieh Chou, Jun-Hung Lin, Chi-Ying F. Huang, Sai-Ching J. Yeung and Mong-Hong Lee

Initial ovarian sensitivity index predicts embryo quality and pregnancy potential in the first days of controlled ovarian stimulation

To determine if a modified ovarian sensitivity index (MOSI), based on initial follicular measurements and the initial follicle-stimulating hormone (FSH) dose, can predict the production of high-quality embryos...

Authors: David Camargo-Mattos, Uziel García, Felipe Camargo-Diaz, Ginna Ortiz, Ivan Madrazo and Esther Lopez-Bayghen

Transcriptomics of cumulus cells – a window into oocyte maturation in humans

Cumulus cells (CC) encapsulate growing oocytes and support their growth and development. Transcriptomic signatures of CC have the potential to serve as valuable non-invasive biomarkers for oocyte competency an...

Authors: Brandon A. Wyse, Noga Fuchs Weizman, Seth Kadish, Hanna Balakier, Mugundhine Sangaralingam and Clifford L. Librach

Tumor-suppressor miRNA-27b-5p regulates the growth and metastatic behaviors of ovarian carcinoma cells by targeting CXCL1

MicroRNAs (miRNAs) play crucial functions in the progression of ovarian cancer. MicroRNA-27b-5p (miR-27b-5p) has been identified as a cancer-associated miRNA. Nevertheless, the expression profile of miR-27b-5p...

Authors: Chun Hua Liu, Xue Ning Jing, Xiao Lan Liu, Shan Yong Qin, Min Wei Liu and Chun Hong Hou

Chemotherapy is not necessary for early-stage serous and endometrioid ovarian cancer after undergoing comprehensive staging surgery

In order to investigate whether adjuvant chemotherapy is essential for patients with early-stage serous and endometrioid epithelial ovarian cancer, the present study collected data from the US Surveillance, Ep...

Authors: Shuqing Li and Zhiling Zhu

MiR-23a induced the activation of CDC42/PAK1 pathway and cell cycle arrest in human cov434 cells by targeting FGD4

MiRNAs play important roles in the development of ovarian cancer, activation of primitive follicles, follicular development, oocyte maturation and ovulation. In the present study, we investigated the specific ...

Authors: Ji Lin, Huijuan Huang, Liheng Lin, Weiwei Li and Jianfen Huang

Serum D-dimer, albumin and systemic inflammatory response markers in ovarian clear cell carcinoma and their prognostic implications

This study attempts to evaluate whether preoperative systemic inflammatory response (SIR) markers or other hematological variables, such as albumin, D-dimer, and carbohydrate antigen 125, play roles in predict...

Authors: Wei Chen, Siyuan Zhong, Boer Shan, Shuling Zhou, Xiaohua Wu, Huijuan Yang and Shuang Ye

Assisted hatching of vitrified-warmed blastocysts prior to embryo transfer does not improve pregnancy outcomes

This study aims to determine the impact of assisted hatching (AH) on pregnancy outcomes in vitrified-warmed blastocyst transfers, and evaluate if embryo expansion or morphology influences outcomes.

Authors: Charis Ng, Marta Wais, Taryn Nichols, Sarah Garrow, Julius Hreinsson, Zhong-Cheng Luo and Crystal Chan

Follicular phase length has no influence on frozen-thawed embryo transfers in natural cycles

Whether menstrual variability in women with regular and ovulatory cycle could affect embryo implantation remains controversial, with conflicting evidences presented in the literature. Thus, in this study, we e...

Authors: Ying Ying, Fuman Qiu, Qing Huang, Sichen Li, Haiying Liu and Jianqiao Liu

Expression of metalloproteinases MMP-2 and MMP-9 is associated to the presence of androgen receptor in epithelial ovarian tumors

The current study evaluated the metalloproteinases MMP-2 and MMP-9 expression in epithelial cells and the surrounding stroma in ovarian tumors and the association of MMPs with the histological subtypes, the cl...

Authors: Flavia Morales-Vásquez, Rocío Castillo-Sánchez, María J. Gómora, Miguel Ángel Almaraz, Enrique Pedernera, Delia Pérez-Montiel, Elizabeth Rendón, Horacio Noé López-Basave, Edgar Román-Basaure, Sergio Cuevas-Covarrubias, Juan Maldonado-Cubas, Antonio Villa and Carmen Mendez

WISP2 promotes cell proliferation via targeting ERK and YAP in ovarian cancer cells

Wnt-inducible signaling pathway protein 2 (WISP2) is a wnt1-induced signaling pathway protein 2. Although studies indicate that WISP2 may promote the development of various tumors, its role in ovarian cancer r...

Authors: Zi-Qing Shi, Zi-Yan Chen, Yao Han, Heng-Yan Zhu, Meng-Dan Lyu, Han Zhang, Yi Zhang, Liu-Qing Yang and Wei-Wei Pan

LncRNA CTBP1-AS2 regulates miR-216a/ PTEN to suppress ovarian cancer cell proliferation

We analyzed TCGA dataset and observed the downregulation of CTBP1-AS2 in ovarian cancer (OC), while the function of CTBP1-AS2 has only been investigated in diabetes and cardiomyocyte hypertrophy, but not in ca...

Authors: Kaiying Cui and Genhai Zhu

Anti-proliferative activities of Byrsocarpus coccineus Schum. and Thonn. (Connaraceae) using ovarian cancer cell lines

Ovarian cancer (OvCa) is one of the most lethal tumors of gynecologic malignancies, due to lack of early detection, and a high rate of metastasis. The standard treatment for OvCa is surgery and cytotoxic chemo...

Authors: Caroline E. Ukwade, Osaretin A. T. Ebuehi, Rahmat A. Adisa, Santosh K. Singh and Rajesh Singh

Bioinformatics analysis of gene expression profile of serous ovarian carcinomas to screen key genes and pathways

Serous ovarian carcinomas (SCA) are the most common and most aggressive ovarian carcinoma subtype which etiology remains unclear. To investigate the prospective role of mRNAs in the tumorigenesis and progressi...

Authors: Hongjun Fei, Songchang Chen and Chenming Xu

circRNA-UBAP2 promotes the proliferation and inhibits apoptosis of ovarian cancer though miR-382-5p/PRPF8 axis

circular RNAs (circRNAs) have been reported to be essential regulators of multiple malignant cancers. However, the functions of circRNAs in ovarian cancer need to be further explored. The aim of our study is t...

Authors: Qin Xu, Bo Deng, Manlin Li, Yang Chen and Li Zhuan

Salpingectomy may decrease antral follicle count but not live birth rate for IVF-ET patients aged 35–39 years: a retrospective study

Problems with fallopian tubes are one of the main reasons for women to undergo in vitro fertilization-embryo transfer (IVF-ET). A large proportion of women with ectopic pregnancy, fallopian tube obstruction an...

Authors: Tong Chen, Feiyan Zhao, Qin Wang, Chang Liu, Yonglian Lan, Shuyu Wang, Zhimin Xin and Xiaokui Yang

Withaferin A: a potential therapeutic agent against COVID-19 infection

The outbreak and continued spread of the novel coronavirus disease 2019 (COVID-19) is a preeminent global health threat that has resulted in the infection of over 11.5 million people worldwide. In addition, th...

Authors: Alex R. Straughn and Sham S. Kakar

Platelet count as a biomarker for monitoring treatment response and disease recurrence in recurrent epithelial ovarian cancer

We sought to determine the impact of pretreatment plasma platelet levels, dimerized plasmin fragment (D-dimer) and fibrinogen in recurrent epithelial ovarian cancer (EOC) and the impact of platelet levels on S...

Authors: Qinghong Hu, Abha Hada and Liping Han

Bioinformatic analysis reveals MIR502 as a potential tumour suppressor in ovarian cancer

Ovarian cancer (OC) is a major cause of death among women due to the lack of early screening methods and its complex pathological progression. Increasing evidence has indicated that microRNAs regulate gene exp...

Authors: Yan Li, Qi Wang, Ning Ning, Fanglan Tang and Yan Wang

Cul4B promotes the progression of ovarian cancer by upregulating the expression of CDK2 and CyclinD1

Ovarian cancer is one of the most common malignant tumors in the female reproductive system with the highest mortality rate. Cul4B participates in the oncogenesis and progression of several malignant tumors. H...

Authors: Peng-jing Duan, Juan-hong Zhao and Li-li Xie

Poorer prognosis of ovarian squamous cell carcinoma than serous carcinoma: a propensity score matching analysis based on the SEER database

Ovarian squamous cell carcinoma (SCC) is a rare cancer with possible poor survival, however no direct evidence supports this viewpoint and the independent prognostic factors are controversial. Patients with ov...

Authors: Cheng Zhang and Tai Ma

Recent trends in stem cell therapy for premature ovarian insufficiency and its therapeutic potential: a review

Stem cell therapy is attracting attention in the field of regenerative medicine and is advancing rapidly. Many recent studies have applied stem cell therapy to treat reproductive system diseases; however, data...

Authors: Jeeyoon Na and Gi Jin Kim

Role of gut microbiota in the development of insulin resistance and the mechanism underlying polycystic ovary syndrome: a review

Polycystic ovary syndrome (PCOS) is a complex endocrine and metabolic disorder. Typically, it is characterized by hirsutism, hyperandrogenism, ovulatory dysfunction, menstrual disorders and infertility. To dat...

Authors: Fang-fang He and Yu-mei Li

Long non-coding RNA THOR promotes ovarian Cancer cells progression via IL-6/STAT3 pathway

Ovarian cancer (OC) is one of the most common malignant tumors in the world. The prognosis of OC remains poor due to the advanced stage and distant metastasis at the time of diagnosis. Recently, a novel lncRNA...

Authors: Jing Ge, Tao Han, Lili Shan, Jing Na, Ya Li and Jun Wang

Pure dysgerminoma of the ovary: CT and MRI features with pathological correlation in 13 tumors

To investigate the spectrum of CT and MRI findings of dysgerminoma of the ovary.

Authors: Shuhui Zhao, Fan Sun, Lei Bao, Caiting Chu, Haiming Li, Qiufeng Yin, Wenbin Guan and Dengbin Wang

The value of secondary neoadjuvant chemotherapy in platinum-sensitive recurrent ovarian cancer: a case-control study post GOG-0213 trial

The prognostic value and optimal resection outcome related factors of the secondary cytoreduction surgery (SCR) in Platinum-sensitive recurrent ovarian cancer (PSOC) patients were still in doubt. The present r...

Authors: Hongyuan Gu, Rui Zhou, Jing Ni, Xia Xu, Xianzhong Cheng, Yan Li and Xiaoxiang Chen

Extended doxycycline treatment versus salpingectomy in the management of patients with hydrosalpinx undergoing IVF-ET

The aim of this study was to determine whether the treatment with doxycycline before and after oocyte retrieval is as effective as salpingectomy in minimizing the detrimental effect of hydrosalpinx on the outc...

Authors: Usama M. Fouda, Hesham S. Elshaer, Mohamed A. Youssef and Fatma F. Darweesh

Anti-tumor activities of probiotics in cervical cancer

Cervical cancer is considered as an important malignancy among women worldwide. Currently-used treatments of cervical cancer are reported to be cytotoxic for patients. Moreover, these therapies have shown some...

Authors: Moghaddaseh Jahanshahi, Parisa Maleki Dana, Bita Badehnoosh, Zatollah Asemi, Jamal Hallajzadeh, Mohammad Ali Mansournia, Bahman Yousefi, Bahram Moazzami and Shahla Chaichian

Serum amyloid a, a potential biomarker both in serum and tissue, correlates with ovarian cancer progression

Ovarian cancer is the most fatal gynecologic malignancy worldwide due to its vagueness, delay in diagnosis, recurrence, and drug resistance. Therefore, a new type of ovarian cancer treatment prediction biomark...

Authors: Ze Li, Yongwang Hou, Meng Zhao, Tianning Li, Yahui Liu, Jiao Chang and Li Ren

Does daily co administration of gonadotropins and letrozole during the ovarian stimulation improve IVF outcome for poor and sub optimal responders?

Co-administration of letrozole during the first 5 days of ovarian stimulation was suggested to improve IVF outcomes in poor responders. We aimed to determine whether poor/sub-optimal responders might benefit f...

Authors: Moran Shapira, Raoul Orvieto, Oshrit Lebovitz, Ravit Nahum, Adva Aizer, Aliza Segev-Zahav and Jigal Haas

Differences in immune-related gene expressions and tumor-infiltrating lymphocytes according to chemotherapeutic response in ovarian high-grade serous carcinoma

High-grade serous carcinoma (HGSC) of the ovary is the most common subtype of epithelial ovarian cancer (EOC) and has an overall poor prognosis. There is increasing awareness of the importance of immune cell p...

Authors: Kyung Un Choi, Ahrong Kim, Jee Yeon Kim, Ki Hyung Kim, Chungsu Hwang, So Jung Lee, Won Young Park, Sejin Jung, Hye Jeong Choi and Kyungbin Kim