Articles

Protective role of Ficus deltoidea against BPA-induced impairments of the follicular development, estrous cycle, gonadotropin and sex steroid hormones level of prepubertal rats

Ficus deltoidea is one of the well-known medicinal plants in Malaysia that is traditionally used by the Malay community to treat various ailments and for maintenance of female reproductive health. The objective o...

Authors: Siti Sarah Mohamad Zaid, Shatrah Othman and Normadiah M. Kassim

Expression of Concern to: Does ovary need D-chiro-inositol?

Authors: Rosalbino Isabella and Emanuela Raffone

Isolated ovarian tuberculosis in an Immuno- competent woman in the post partum period: case report

Pelvic tuberculosis is a rare form of extrapulmonary tuberculosis. It commonly involves the fallopian tubes and the uterus from a lympho-hematogeneous spread. The presentation of pelvic tuberculosis as an isol...

Authors: Wondimu Gudu

Is the aging human ovary still ticking?: Expression of clock-genes in luteinized granulosa cells of young and older women

It has been shown – mostly in animal models - that circadian clock genes are expressed in granulosa cells and in corpora luteum and might be essential for the ovulatory process and steroidogenesis.

Authors: Amnon Brzezinski, A. Saada, H. Miller, NA Brzezinski-Sinai and A. Ben-Meir

Decrease in preovulatory serum estradiol is a valuable marker for predicting premature ovulation in natural/unstimulated in vitro fertilization cycle

Premature ovulation occurs at a high rate in natural-cycle in vitro fertilization (IVF), and cycle cancellation further hampers the overall efficiency of the procedure. While lower levels of estradiol (E2) are...

Authors: Xuefeng Lu, Shuzin Khor, Qianqian Zhu, Lihua Sun, Yun Wang, Qiuju Chen, Ling Wu, Yonglun Fu, Hui Tian, Qifeng Lyu, Renfei Cai and Yanping Kuang

Identification of core genes in ovarian cancer by an integrative meta-analysis

Epithelial ovarian cancer is one of the most severe public health threats in women. Since it is still challenging to screen in early stages, identification of core genes that play an essential role in epithel...

Authors: Wenyu Li, Zheran Liu, Bowen Liang, Siyang Chen, Xinping Zhang, Xiaoqin Tong, Weiming Lou, Lulu Le, Xiaoli Tang and Fen Fu

Luteolin sensitizes the antitumor effect of cisplatin in drug-resistant ovarian cancer via induction of apoptosis and inhibition of cell migration and invasion

Luteolin, a polyphenolic flavone, has been demonstrated to exert anti-tumor activity in various cancer types. Cisplatin drug resistance is a major obstacle in the management of ovarian cancer. In the present s...

Authors: Haixia Wang, Youjun Luo, Tiankui Qiao, Zhaoxia Wu and Zhonghua Huang

Diagnostic value of the gynecology imaging reporting and data system (GI-RADS) with the ovarian malignancy marker CA-125 in preoperative adnexal tumor assessment

The purpose of this study is to assess the preoperative evaluation of an adnexal mass using the GI-RADS classification and to verify whether CA-125 measurement can offer any additional benefits to the GI-RADS-...

Authors: Michal Migda, Migda Bartosz, Marian S. Migda, Marcin Kierszk, Gieryn Katarzyna and Marek Maleńczyk

Comparison of stage III mucinous and serous ovarian cancer: a case-control study

The purpose of this case-control study was to compare the prognoses of women with stage III mucinous ovarian carcinoma (MOC) who received maximal or optimal cytoreduction followed by paclitaxel plus carboplati...

Authors: Zeliha Firat Cuylan, Emine Karabuk, Murat OZ, Ahmet Taner Turan, Mehmet M. Meydanli, Salih Taskin, Mustafa Erkan Sari, Hanifi Sahin, Suat C. Ulukent, Ozgur Akbayir, Kemal Gungorduk, Tayfun Gungor, Mehmet F. Kose and Ali Ayhan

DAXX promotes ovarian cancer ascites cell proliferation and migration by activating the ERK signaling pathway

The death-domain-associated protein (DAXX) was originally identified as a protein that binds to the transmembrane death receptor FAS and enhances both FAS-induced and transforming growth factor-β-dependent apo...

Authors: Sheng-Bing Liu, Xue-Ping Lin, Ying Xu, Zhong-Fei Shen and Wei-Wei Pan

Mitochondrial membrane depolarization enhances TRAIL-induced cell death in adult human granulosa tumor cells, KGN, through inhibition of BIRC5

Cellular metabolic changes that accompany malignant transformation have been heralded as hallmark features of cancer. However, metabolic signatures between neoplasms can be unique, allowing for distinctions in...

Authors: Julie A. MacDonald, Niharika Kura, Carleigh Sussman and Dori C. Woods

Mass spectrometry-based proteomics techniques and their application in ovarian cancer research

Ovarian cancer has emerged as one of the leading cause of gynecological malignancies. So far, the measurement of CA125 and HE4 concentrations in blood and transvaginal ultrasound examination are essential ovar...

Authors: Agata Swiatly, Szymon Plewa, Jan Matysiak and Zenon J. Kokot

Intrafollicular fibroblast growth factor 13 in polycystic ovary syndrome: relationship with androgen levels and oocyte developmental competence

Fibroblast growth factor 13 (FGF13) is one of the most highly expressed FGF family members in adult mouse ovary. However, its precise roles in ovarian function remain largely unknown. We sought to evaluate the...

Authors: Yu Liu, Shengxian Li, Tao Tao, Xiaoxue Li, Qinling Zhu, Yu Liao, Jing Ma, Yun Sun and Wei Liu

CT of ovarian cancer: 3D cinematic rendering for preoperative evaluation

Ovarian cancer is the second most common gynecologic malignancy. As the primary imaging modality, computed tomography (CT) can provide staging information for preoperative planning and determination of surgica...

Authors: Yi-ren Jin, Xie-lan Yang, Qin-qing Li, Zhi-ling Yan, Hong-ying Yang and Chengde Liao

Prognostic value of various subtypes of extracellular DNA in ovarian cancer patients

Patients with ovarian cancer represent a heterogeneous population with a variable prognosis and response to chemotherapy. Plasma DNA has been shown to have a prognostic value in different types of cancer inclu...

Authors: Katarina Kalavska, Tomas Minarik, Barbora Vlkova, Denisa Manasova, Michaela Kubickova, Andrej Jurik, Jozef Mardiak, Jozef Sufliarsky, Peter Celec and Michal Mego

Assessment of Prostaglandin-Endoperoxide Synthase 2 and Versican gene expression profile from the cumulus cells: association with better in vitro fertilization outcomes

Current methods for determining superior embryo quality (morphological assessment) are unable to compensate for poor pregnancy outcomes. Due to the importance of the cumulus-oocyte complex and the value of cum...

Authors: Azucena Ocampo, Jeimy Pedraza, Ginna Ortiz, Elizabeth Hernández-Pérez, Leonardo Porchia and Esther López-Bayghen

Gonadotropin and steroid hormones regulate pluripotent very small embryonic-like stem cells in adult mouse uterine endometrium

Very small embryonic-like stem cells (VSELs) exist in adult organs, express pluripotent markers and have the ability to differentiate into three germ layers in vitro. Testicular, ovarian and hematopoietic stem/pr...

Authors: Kreema James, Deepa Bhartiya, Ranita Ganguly, Ankita Kaushik, Kavita Gala, Pushpa Singh and S. M. Metkari

Non-classical 11β-hydroxylase deficiency caused by compound heterozygous mutations: a case study and literature review

11β-hydroxylase deficiency (11OHD) is extremely rare, and reports of non-classical 11OHD are even rarer. Non-classical 11OHD usually presents as premature adrenarche, hyperandrogenism, menstrual disorders, and...

Authors: Dongdong Wang, Jiahui Wang, Tong Tong and Qing Yang

Exosomal miR-1290 is a potential biomarker of high-grade serous ovarian carcinoma and can discriminate patients from those with malignancies of other histological types

microRNAs (miRNAs) stably exist in circulating blood encapsulated in extracellular vesicles such as exosomes; therefore, serum miRNAs have the potential to serve as novel cancer biomarkers. New diagnostic mark...

Authors: Masaki Kobayashi, Kenjiro Sawada, Koji Nakamura, Akihiko Yoshimura, Mayuko Miyamoto, Aasa Shimizu, Kyoso Ishida, Erika Nakatsuka, Michiko Kodama, Kae Hashimoto, Seiji Mabuchi and Tadashi Kimura

The effects of probiotic and selenium co-supplementation on parameters of mental health, hormonal profiles, and biomarkers of inflammation and oxidative stress in women with polycystic ovary syndrome

The aim of this study was to evaluate the effect of the co-administration of probiotic and selenium on parameters of mental health, hormonal profiles, and biomarkers of inflammation and oxidative stress in wom...

Authors: Mehri Jamilian, Shirin Mansury, Fereshteh Bahmani, Zahra Heidar, Elaheh Amirani and Zatollah Asemi

Persistent megalocystic ovaries after ovarian hyperstimulation syndrome in a postpartum patient with polycystic ovarian syndrome: a case report

Ovary enlargement is common in controlled ovarian stimulation, which could continue several months during a successful pregnancy. However, persistent megalocystic ovaries 3 years after ovarian hyperstimulation...

Authors: Jinghua Shi, Xinyu Ren, Qinjie Tian, Aijun Sun and Rong Chen

Does a poor-quality embryo have an adverse impact on a good-quality embryo when transferred together?

In some in vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI) cycles, we may consider transferring one poor-quality embryo with one good-quality embryo. Previous studies have indicated that t...

Authors: Jiaheng Li, Mingze Du, Zhan Zhang, Yichun Guan, Xingling Wang, Xiao Zhang, Jing Liu, Zhouhui Pan, Bijun Wang and Wenxia Liu

Anaplastic carcinoma in ovarian seromucinous cystic tumor of borderline malignancy

The mortality rate of ovarian cancer is the highest among all gynecological malignancies in Japan. Ovarian tumors are classified as benign, borderline malignant, or malignant. Anticipating the histological sub...

Authors: Toshiyuki Okumura, Etuo Muronosono, Masahiko Tsubuku, Yasuhisa Terao, Satoru Takeda and Masanori Maruyama

Pregnancy after drug-free in vitro activation of follicles and fresh tissue autotransplantation in primary ovarian insufficiency patient: a case report and literature review

The aim of this report was to describe a case of pregnancy after drug-free in vitro activation (IVA) of follicles and fresh tissue autotransplantation in primary ovarian insufficiency (POI) patient and to revi...

Authors: F. Fabregues, J. Ferreri, J.M. Calafell, V. Moreno, A. Borrás, D. Manau and F. Carmona

Use of a Small Animal Radiation Research Platform (SARRP) facilitates analysis of systemic versus targeted radiation effects in the mouse ovary

Radiation exposure is known to cause accelerated aging and damage to the ovary, but the contribution of indirect versus direct effects is not well understood. We used the Small Animal Radiation Research Platfo...

Authors: Allison R. Grover, Bruce F. Kimler and Francesca E. Duncan

A case of ovarian clear cell carcinoma arising from ovarian mature cystic teratoma

It is well known that ovarian mature cystic teratomas (MCTs) occasionally go through malignant transformations. Among these, approximately 75% of histological types are squamous cell carcinoma, with the other ...

Authors: Kazuya Maeda, Yoshito Terai, Shinichi Terada, Hiroshi Maruoka, Yuhei Kogata, Keisuke Ashihara, Yoshimichi Tanaka, Tomohito Tanaka, Hiroshi Sasaki, Satoshi Tsunetoh, Takashi Yamada and Masahide Ohmichi

Ovarian teratoma in children: a plea for collaborative clinical study

Although teratomas are the most common histologic subtype of childhood ovarian germ cell tumors, their appropriate treatment in this age group still remains unclear. Paucity of research dedicated exclusively t...

Authors: Justyna Łuczak and Maciej Bagłaj

The value of MRI for differentiating benign from malignant sex cord-stromal tumors of the ovary: emphasis on diffusion-weighted MR imaging

To investigate MRI for differentiating benign from malignant sex cord-stromal tumors of the ovary (SCSTs) emphasizing on the value of diffusion-weighted (DW) magnetic resonance (MR) imaging.

Authors: Shu-Hui Zhao, Hai-Ming Li, Jin-Wei Qiang, Deng-Bin Wang and Hua Fan

The role of vitamin D in ovarian cancer: epidemiology, molecular mechanism and prevention

Vitamin D is a fat-soluble prohormone best known for its role in maintaining calcium homeostasis. Large numbers of epidemiological studies have shown that vitamin D plays an important role in cancer prevention...

Authors: Hui Guo, Jing Guo, Wenli Xie, Lingqin Yuan and Xiugui Sheng

Live birth rate after human chorionic gonadotropin priming in vitro maturation in women with polycystic ovary syndrome

In vitro maturation (IVM) has some advantages over conventional in vitro fertilization (IVF), particularly in polycystic ovary syndrome (PCOS) where the risk of ovarian hyperstimulation is high. We studied the...

Authors: V. N. A. Ho, T. D. Pham, A. H. Le, T. M. Ho and L. N. Vuong

Characterization of stem cell and cancer stem cell populations in ovary and ovarian tumors

Ovarian cancer is a complicated malady associated with cancer stem cells (CSCs) contributing to 238,700 estimated new cases and 151,900 deaths per year, worldwide. CSCs comprise a tiny fraction of tumor-bulk r...

Authors: Seema C. Parte, Surinder K. Batra and Sham S. Kakar

Low fertility may be a significant determinant of ovarian cancer worldwide: an ecological analysis of cross- sectional data from 182 countries

Ageing, socioeconomic level, obesity, fertility, relaxed natural selection and urbanization have been postulated as the risk factors of ovarian cancer (OC56). We sought to identify which factor plays the most ...

Authors: Wenpeng You, Ian Symonds and Maciej Henneberg

Reproductive aging and elective fertility preservation

Reproductive aging is a natural process that occurs in all women, eventually leading to reproductive senescence and menopause. Over the past half century there has been a trend towards delayed motherhood. Post...

Authors: Rani Fritz and Sangita Jindal

Comparative study of endometrioid borderline ovarian tumor with and without endometriosis

Synchronous endometriosis has been poorly studied in women with endometrioid borderline ovarian tumors (EBOTs). The aims of this study were to compare the clinicopathological features and prognosis of EBOTs wi...

Authors: Wen Zhang, Shuangzheng Jia, Yang Xiang, Junjun Yang, Congwei Jia and Jinhua Leng

Innovative multi-protectoral approach increases survival rate after vitrification of ovarian tissue and isolated follicles with improved results in comparison with conventional method

In recent years, autotransplantation of cryopreserved ovarian tissue became a promising approach to preserve female fertility. The slow freezing is the most effective technique which resulted in greater live b...

Authors: Dmitry Nikiforov, Valentina Russo, Delia Nardinocchi, Nicola Bernabò, Mauro Mattioli and Barbara Barboni

Characterization of ovarian cancer cells and tissues by Fourier transform infrared spectroscopy

Ovarian cancer is the most lethal of gynecological malignancies. Fourier Transform Infrared (FTIR) spectroscopy has gradually developed as a convenient, inexpensive and non-destructive technique for the study ...

Authors: Lei Li, Xiaoning Bi, Hengzi Sun, Simiao Liu, Mei Yu, Ying Zhang, Shifu Weng, Limin Yang, Yanan Bao, Jinguang Wu, Yizhuang Xu and Keng Shen

Predicted luteal phase length has no influence on success of vitrified-warmed blastocyst transfer in natural cycle

This study evaluated the influence of menstrual cycle length, menstrual cycle variability and predicted luteal phase length on the success of vitrified-warmed blastocyst transfer in natural menstrual cycle usi...

Authors: M. Reljič and J. Knez

Determination of sialic acid in saliva by means of surface-enhanced Raman spectroscopy as a marker in adnexal mass patients: ovarian cancer vs benign cases

To demonstrate the use of surface-enhanced Raman spectroscopy (SERS) to determine sialic acid (SA) levels in saliva using silver nanoparticles as substrates, in adnexal mass patients scheduled for surgical int...

Authors: José de Jesús Zermeño-Nava, Marco Ulises Martínez-Martínez, Ana Laura Rámirez-de-Ávila, Aida Catalina Hernández-Arteaga, Ma. Guadalupe García-Valdivieso, Alondra Hernández-Cedillo, Miguel José-Yacamán and Hugo Ricardo Navarro-Contreras

Is the ovarian reserve influenced by vitamin D deficiency and the dress code in an infertile Iranian population?

In the recent years, vitamin D has become a topical subject and a focus of research not only in reproductive medicine but across many medical disciplines. In reproductive medicine, studies have identified an a...

Authors: Soheila Arefi, Gholamreza Khalili, Homa Iranmanesh, Fattaneh Farifteh, Ahmad Hosseini, Human M. Fatemi and Barbara Lawrenz

Discordant anti-müllerian hormone (AMH) and follicle stimulating hormone (FSH) among women undergoing in vitro fertilization (IVF): which one is the better predictor for live birth?

This study sought to clarify the roles of Anti-müllerian hormone (AMH) and follicle stimulating hormone (FSH) in predicting live birth, especially in patients with discordant AMH and FSH. A large IVF data set ...

Authors: Shunping Wang, Yi Zhang, Virginia Mensah, Warren J. Huber III, Yen-Tsung Huang and Ruben Alvero

Fresh versus frozen embryo transfer for full-term singleton birth: a retrospective cohort study

Improvements in vitrification and frozen embryo transfer (FET) technologies have rapidly increased, and some evidence suggests that FET may increase pregnancy rates and lead to more favourable perinatal outcom...

Authors: Junwei Zhang, Mingze Du, Zhe Li, Lulu Wang, Jijun Hu, Bei Zhao, Yingying Feng, Xiaolin Chen and Lijun Sun

Establishment and molecular characterization of a human ovarian clear cell carcinoma cell line (FDOV1)

Ovarian clear cell carcinoma is a distinct histologic subtype with grave survival. The underlying molecular mechanism is not fully elucidated. However, we don’t have many cell lines, which are useful experimen...

Authors: Wei Jiang, Shuang Ye, Libing Xiang, Wentao Yang, Tiancong He, Xuan Pei, Lin Guo and Huijuan Yang

Expression of Concern to: Does ovary need D-chiro-inositol?

Authors: Rosalbino Isabella and Emanuela Raffone

Wounding promotes ovarian cancer progression and decreases efficacy of cisplatin in a syngeneic mouse model

Primary cytoreductive surgery followed by adjuvant chemotherapy is the standard treatment for advanced epithelial ovarian cancer. The average interval between surgery and chemotherapy initiation is approximate...

Authors: Yooyoung Lee, Alexandra Kollara, Taymaa May and Theodore J. Brown

Effect of resveratrol and metformin on ovarian reserve and ultrastructure in PCOS: an experimental study

PCOS is a reproductive hormonal abnormality and a metabolic disorder. It is frequently associated with insulin resistance, hyperandrogenism, chronic inflammation, and oxidative stress. We aim to investigate th...

Authors: Selenay Furat Rencber, Sema Kurnaz Ozbek, Ceyla Eraldemır, Zehra Sezer, Tugba Kum, Sureyya Ceylan and Elif Guzel

Age-dependent difference in impact of fertility preserving surgery on disease-specific survival in women with stage I borderline ovarian tumors

This study was to determine age-specific impact of fertility preserving surgery on disease-specific survival in women with stage I borderline ovarian tumors (BOTs). Patients diagnosed during 1988–2000 were sel...

Authors: Haiyan Sun, Xi Chen, Tao Zhu, Nanfang Liu, Aijun Yu and Shihua Wang

Endometriosis does not confer improved prognosis in ovarian clear cell carcinoma: a retrospective study at a single institute

Considered as the precursor lesion of a subset of ovarian clear cell carcinoma (OCCC), the prognostic role of endometriosis in OCCC patients remains controversial. This study aimed to investigate the prognosti...

Authors: Ting Zhao, Yu Shao, Yan Liu, Xiao Wang, Luyao Guan and Yuan Lu

Alpha-fetoprotein-producing ovarian clear cell adenocarcinoma with fetal gut differentiation: a rare case report and literature review

Alpha-fetoprotein (AFP) is a useful tumor marker for ovarian germ cell tumors, particularly yolk sac tumor (YST). It is valuable for both diagnosis and further follow-up. Epithelial ovarian carcinoma (EOC) rar...

Authors: Wei-Ting Chao, Chia-Hao Liu, Chiung-Ru Lai, Yi-Jen Chen, Chi-Mu Chuang and Peng-Hui Wang

Quercetin increases the antioxidant capacity of the ovary in menopausal rats and in ovarian granulosa cell culture in vitro

Menopause is the most important sign of aging in women, and the ovary is the organ most sensitive to aging. Quercetin is a potential antioxidant and free radical scavenger that is widely found in fruits, veget...

Authors: Jiao Wang, Xin Qian, Qiang Gao, Chunmei Lv, Jie Xu, Hongbo Jin and Hui Zhu

DNA damage repair in ovarian cancer: unlocking the heterogeneity

Treatment for advanced ovarian cancer is rarely curative; three quarters of patients with advanced disease relapse and ultimately die with resistant disease. Improving patient outcomes will require the introdu...

Authors: Mary Ellen Gee, Zahra Faraahi, Aiste McCormick and Richard J. Edmondson