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Epithelial ovarian cancer (EOC) has one of the worst prognoses among gynecologic cancers. An appropriate screening method is not available...
In this study, we tested the hypothesis that single nucleotide polymorphisms (SNPs) of differentiation-associated human gene icb-1 (C1orf38) may be associated with ovarian cancer susceptibility. For this purpose,...
Studies on the association between obesity and ovarian cancer survival have had conflicting results. We reviewed ... references used in multivariate analysis, and ovarian cancer stage.
Hyaluronic acid is a prognostic factor in ovarian cancers. It is also a component of Hyaluronic ... surgery will relapse due to the persistence of cancer cells. This study’s objective was to...
Among the pro-inflammatory lipid mediators, platelet-activating factor (PAF) is a major primary and secondary messenger that binds to the PAF-receptor (PAFR). Epidermal growth factor (EGF) is a polypeptide growth...
Gemcitabine (2′, 2′ –difluorodeoxycytidine) is one of many nonplatinum drugs that exhibit activity in recurrent, platinum-resistant ovarian cancer. However, the molecular mechanisms by which ... treatment inhibit...
The editors of Journal of Ovarian Research would like to thank all of our reviewers who have contributed to the journal in volume 6 (2013).
Cryopreservation of the ovarian tissue has shown promising results. However, there remain controversial issues such as the short half-life of grafts. In this aspect, there are some evidences that preconditioni...
Ovarian cystadenocarcinoma is characterized by marked heterogeneity and may be composed of an admixture of histologic growth patterns, including acinar, papillary and solid. In the present study, a case of iso...
The Retraction Note to this article has been published in Journal of Ovarian Research 2016 9:76
The aim of this study was to evaluate the concentrations of IgG antibodies against Hsp60 and Hsp65 in sera of patients with ovarian cancer at various stages of clinical progress and...
The objective of this study was to investigate clinical manifestations of lower extremity edema (LEE) in early ovarian cancer.
Ovarian cancer is the most lethal gynecologic disease due...
High expression of the polymeric immunoglobulin receptor (PIGR) has previously been associated with a favourable prognosis in a few cancer forms, but its expression and relationship with clinical outcome in epith...
The standard treatment of ovarian cancer with chemotherapy often leads to drug resistance ... which is expressed by the majority of epithelial cancers including ovarian carcinomas, and we studied the cytotoxic ef...
We enrolled 139 patients, 40 with ovarian cancer (group I), 82 with benign diseases...
Isolated superficial inguinal metastases without any extended intra-abdominal spread is a rare event in patients with ovarian carcinoma. Here we report an isolated superficial inguinal metastasis in a patient wit...
Tumor-associated macrophages (TAMs) are classified into two major phenotypes, M1 and M2. M1 TAMs suppress cancer progression, while M2 TAMs promote it. ... role of TAMs in the development of ovarian cancer. Here,...
Endometriosis is characterized by the presence of functional endometrial tissue outside of the uterine cavity. It affects 1 in 10 women of reproductive age. This chronic condition commonly leads to consequences s...
In ovarian cancer, intense expression of E-cadherin, β-...
Twenty patients (13 with ovarian cancers and 7 with benign lesions) were evaluated...18F-FDG-PET/CT performed 1 h and 2 h after injection of 18F-FDG. The maximum standardized uptake value (SUVmax) for both time p...
Exosomes are tiny membrane-bound vesicles that are over produced by most proliferating cell types during normal and pathological states. Their levels are up-regulated during pregnancy and disease states such as cancer
...miRNAs are proved to have causal roles in tumorgenesis involving various types of human cancers, but the mechanism is not clear. ... effect of miRNAs on the development of ovarian cancer and the underlying mec...
The Retraction Note to this article has been published in Journal of Ovarian Research 2015 8:17
Epithelial-Mesenchymal Transition (EMT) is a transient and reversible (Mesenchymal-Epithelial Transition or MET) process by which epithelial cells acquire mesenchymal cell characteristics including reduced interc...
The human umbilical cord mesenchymal stem cells (hUCMSCs) have the ability to migrate into tumors and therefore have been considered as an alternative source of mesenchymal progenitors for the therapy of malignan...
Understanding the integration of hormone signaling and how it impacts oncogenesis is critical for improved cancer treatments. Here we elucidate GNAI2 message alterations in ovarian cancer (OvCa). GNAI2 is a heter...
A 60-year-old woman presented with synchronous adrenal metastasis and an inferior vena cava tumor thrombus in the adrenal vein that developed from an ovarian carcinoma. The patient underwent total abdominal hy...
Estrogen causes proliferation of ovarian cancer cells. Although hormone therapy with an anti ... is an optional therapy for recurrent epithelial ovarian cancers, both basic and clinical researches are insufficien...
This study was designed to investigate leptin levels in the fluid in ovarian endometriomas (OEs) and to compare the expression of leptin and its receptors (OBR) in ovarian tissue affected by endometrioma in in...
Aim of this prospective, case–control study was to evaluate uterine arteries’ blood flow before and after laparoscopic surgery in patients with ovarian endometriosis and its possible correlation with infertility.
There are well-known side effects of chemotherapy and radiotherapy that are mainly related to the toxicity and impaired function of vital organs; however, the induction by these therapies of expression of seve...
Ovarian cancer is a cancerous growth arising from the...
The Retraction Note to this article has been published in Journal of Ovarian Research 2015 8:15
To translate the concept of full-conditioning (FC) from animal experiments to the human, and to evaluate the efficacy for adhesion prevention. FC consisted of decreasing acute inflammation by 86% CO2+ 10% N2O + 4...
Both BRCA1 and angiotensin II type 1 receptor (AGTR1) play a critical role in ovarian cancer progression. However, the crosstalk between BRCA1 and AGTR1 signaling pathways remains largely unknown.
The Cancer Genome Atlas (TCGA) Data portal provides ... was to explore the molecular mechanism of ovarian cancer pathogenesis.
The Retraction Note to this article has been published in Journal of Ovarian Research 2015 8:18
Ovarian cystic tumors with a mural nodule are a rare entity. We report a case of a mural nodule of anaplastic spindle cell carcinoma in an ovarian mucinous cystic tumor of borderline malignancy. The patient wa...
The importance of surface epithelium and epithelial inclusion cysts in the ovary arises from studies demonstrating that these structures are susceptible to epithelial ovarian cancer development. The expression of...
Epithelial ovarian cancer (EOC) is still a major gynecologic ... expression of microRNAs is widely dysregulated in ovarian cancer; and that they have evolved into tumorigenic...
Although transplantation of cryopreserved ovarian tissue is a promising approach to restore fertility in cancer patients, it is not advisable for women...
Resistance to apoptosis is a major problem in ovarian cancer (OC) and correlates with poor prognosis. ... attenuate TRAIL-induced apoptosis in a variety of cancer cells, including OC cells. OPG-mediated...
During the days August 22–24, 2013 has been held in Harbin (China) an International Consensus Conference aimed to improve the quality and the reporting of the randomized controlled trials (RCTs) in infertility...
RNA interference technology has shown high therapeutic potential for cancer treatment. However, serum instability, poor tissue...in vivo.... To overcome these limitations and improve the specificity for ovarian cancer
Recently, 14-3-3 zeta protein was identified as a potential serum biomarker of epithelial ovarian cancer (EOC). The goal of this study...
Ovarian cancer remains an on-going challenge mainly due ... development of drug resistance and also because the cancer is likely to have metastasized at the...
Lysine-specific demethylase 1 (LSD1, also known as KDM1A and AOF2) is a chromatin-modifying activity that catalyzes the removal of methyl groups from lysine residues in histone and non-histone proteins, regulatin...
Oxidative damage and DNA repair dysfunction are associated with carcinogenesis. 8-OHdG is one of the major oxidative DNA adducts. Present work aims to investigate whether the expression of 8-OHdG and its key r...
The inhibition of two major anti-apoptotic proteins, Bcl-xL...and Mcl-1, appears essential to destroy chemoresistant cancer cells. We have studied their concomitant inhibition...
Preclinical evaluation of the anti-neoplastic activity of antisense oligonucleotide (AS) suppression of human insulin-like growth factor I receptor (IGF-IR) in human epithelial ovarian cancer (EOC).
It is known that caloric restriction extends lifespan and can minimize age-related dysfunction of the reproductive system. We became interested in how caloric restriction influences apoptosis, which is a cruci...
Earlier, proteomic profiling of a Serous Ovarian Carcinoma (SeOvCa) progression model in our lab had identified significantly enriched expression of three double-strand break (DSB) -repair proteins viz....RAD50, ...
Lei and Spradling in a recent study published in PNAS failed to detect ‘germline cysts’ by elegant studies using lineage tracing approach and thus concluded that adult mouse ovaries lack stem cells. They propo...
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