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  1. Polycystic ovary syndrome (PCOS) is one of the most complex endocrine disorders in women of reproductive age. Abnormal proliferation of granulosa cells (GCs) is an important cause of PCOS. This study aimed to ...

    Authors: Jingyu Liu, Jie Li, Xin Wu, Mei Zhang, Guijun Yan, Haixiang Sun and Dong Li
    Citation: Journal of Ovarian Research 2024 17:44
  2. Polycystic ovary syndrome (PCOS) is a gynecological endocrine disease and could be considered a metabolic disease because it is often accompanied by obesity and insulin resistance. Brown adipose tissue (BAT) t...

    Authors: Yan Yan, Fangfang Di, Ruoxi Zhang, Liwen Song, Runjie Zhang and Jin Qiu
    Citation: Journal of Ovarian Research 2024 17:43
  3. To investigate the effects of metformin (MET) monotherapy and pioglitazone plus MET (PIOMET) therapy on gonadal and metabolic profiles in normal-weight women with polycystic ovary syndrome (PCOS).

    Authors: Han Zhao, Jiaqi Zhang, Chuan Xing, Xiangyi Cheng and Bing He
    Citation: Journal of Ovarian Research 2024 17:42
  4. Mucin 16 (MUC16) overexpression is linked with cancer progression, metastasis, and therapy resistance in high grade serous ovarian cancer and other malignancies. The cleavage of MUC16 forms independent bimodul...

    Authors: Kwangkook Lee, Kay Perry, Mengyao Xu, Irva Veillard, Raj Kumar, Thapi Dharma Rao, Bo R Rueda, David R Spriggs and Oladapo O Yeku
    Citation: Journal of Ovarian Research 2024 17:41
  5. Poor ovarian response (POR) is a big challenge for in vitro fertilization. The traditional Chinese medicine, Cai’s Prescription of Tonifying Kidney and Strengthening Vitals (Cai’s Prescription) has yielded sat...

    Authors: Zheng Wang, Denghao Liu, Yonghong Nie and Qinhua Zhang
    Citation: Journal of Ovarian Research 2024 17:40
  6. PCOS is a widespread disease that primarily caused in-pregnancy in pregnant-age women. Normoandrogen (NA) and Hyperandrogen (HA) PCOS are distinct subtypes of PCOS, while bio-markers and expression patterns fo...

    Authors: Wensu Liu, Tianyu Tang, Jianwei Feng, Chunyu Wang, Lin Lin, Shengli Wang, Kai Zeng, Renlong Zou, Zeyu Yang and Yue Zhao
    Citation: Journal of Ovarian Research 2024 17:38
  7. The present study aimed to explore the maternal and perinatal risks in cases of monozygotic twins (MZT) following frozen-thawed embryo transfer (FET).

    Authors: Jing Lin, Kai Zhang, Fenglu Wu, Bian Wang, Weiran Chai, Qianqian Zhu, Jialyu Huang and Jiaying Lin
    Citation: Journal of Ovarian Research 2024 17:36
  8. PAQR7 plays a key role in cell apoptosis as a progesterone membrane receptor. The physiological mechanism of PAQR7 in ovarian function and its anti-apoptotic action in mammals remain poorly understood.

    Authors: Jia Li, Yiting Liu, Jinxia He, Zixuan Wu, Fang Wang, Jian Huang, Liping Zheng and Tao Luo
    Citation: Journal of Ovarian Research 2024 17:35
  9. Ovarian cancer (OC) is the most lethal gynecologic malignant tumour. The mechanism promoting OC initiation and progression remains unclear. SET domain bifurcated histone lysine methyltransferase 1(SETDB1) acts...

    Authors: Hongjuan Yang, Lei Sui, Cuicui Cai, Huijun Chu and Yuchao Diao
    Citation: Journal of Ovarian Research 2024 17:34
  10. The etiology of premature ovarian insufficiency, that is, the loss of ovarian activity before 40 years of age, is complex. Studies suggest that genetic factors are involved in 20–25% of cases. The aim of this ...

    Authors: Panpan Long, Le Wang, Hangjing Tan, Ruping Quan, Zihao Hu, Minghua Zeng, Ziheng Deng, Hualin Huang, Jonathan Greenbaum, Hongwen Deng and Hongmei Xiao
    Citation: Journal of Ovarian Research 2024 17:32
  11. Investigating the underlying molecular mechanisms responsible for endometrial dysfunction in women with PCOS is essential, particularly focusing on the role of hyperinsulinemia.

    Authors: Nan-Xing Jiang, Wei-Jie Zhao, Hao-Ran Shen, Dan-feng Du and Xue-Lian Li
    Citation: Journal of Ovarian Research 2024 17:31
  12. Ovarian cancer is the most lethal gynecologic neoplasm, and most patients experience recurrence and chemoresistance. Even the promising immunotherapy showed limited efficacy in ovarian cancer, probably due to ...

    Authors: Ming Du, Qingqing Cai, Jiaan Sun, Mingxing Zhang, Shuo Zhang, Xiaoxia Liu, Mengyu Zhang and Xiaoyan Zhang
    Citation: Journal of Ovarian Research 2024 17:30
  13. Polycystic ovary syndrome (PCOS) is a frequent and complicated endocrine disease that remains a major reason for infertility. Bushenhuoluo Decotion (BSHLD) has been validated to exhibit curative effects on PCO...

    Authors: Qun Huang, Yuanbin Li, Zhuang Chen, Huiping Ou, Yanjiao Tan and Hui Lin
    Citation: Journal of Ovarian Research 2024 17:29
  14. Polycystic Ovary Syndrome (PCOS) affects a significant proportion of human females worldwide and is characterized by hormonal, metabolic, and reproductive dysfunctions, including infertility, irregular menstru...

    Authors: Fatima Muccee, Naeem Mahmood Ashraf, Suhail Razak, Tayyaba Afsar, Nadia Hussain, Fohad Mabood Husain and Huma Shafique
    Citation: Journal of Ovarian Research 2024 17:27
  15. Ovarian cancer (OC) is one of the most common gynecological tumors with high morbidity and mortality. Altered serum N-glycome has been observed in many diseases, while the association between serum protein N-glyc...

    Authors: Si Liu, Chang Tu, Haobo Zhang, Hanhui Huang, Yuanyuan Liu, Yi Wang, Liming Cheng, Bi-Feng Liu, Kang Ning and Xin Liu
    Citation: Journal of Ovarian Research 2024 17:26
  16. Bushen Tiaoxue Granules (BTG) is an empirical Chinese herbal formula that has been used for the treatment of subfertility. The protective effect of BTG on controlled ovarian hyperstimulation (COH)-induced impa...

    Authors: Jia-Cheng Zhang, Hao-Lin Zhang, Xi-Yan Xin, Yu-Tian Zhu, Xin Mao, Hang-Qi Hu, Yu-Xin Jin, Rui-Wen Fan, Xiao-Hui Zhang, Yang Ye and Dong Li
    Citation: Journal of Ovarian Research 2024 17:25
  17. Premature ovarian failure (POF) is a leading cause of women’s infertility without effective treatment. The purpose of this study was to investigate the protective effects of Luffa cylindrica fermentation liquid (...

    Authors: Yueying Feng, Wei Zhang, Xiaowei Xu, Wanzhen Wang, Yuanyuan Xu, Mengqi Wang, Jinfeng Zhang, Hengyi Xu and Fen Fu
    Citation: Journal of Ovarian Research 2024 17:24
  18. In fully grown oocytes, the genome is considered to be globally transcriptionally silenced. However, this conclusion is primarily derived from the results obtained through immunofluorescence staining or inferr...

    Authors: Huiqing An, Xiuwan Wang, Jiashuo Li, Hongzheng Sun, Shuai Zhu, Juan Ge, Longsen Han, Bin Shen and Qiang Wang
    Citation: Journal of Ovarian Research 2024 17:23
  19. The mechanisms and risk factors underlying ovarian cancer (OC) remain under investigation, making the identification of new prognostic biomarkers and improved predictive factors critically important. Recently,...

    Authors: Shaoxuan Liu, Danni Ding, Fangyuan Liu, Ying Guo, Liangzhen Xie and Feng-Juan Han
    Citation: Journal of Ovarian Research 2024 17:22
  20. Women have polycystic ovarian syndrome (PCOS) at higher rates than any other endocrine condition with an average incidence rate of 6 to 8%. Acne is an immune mediate common condition frequently affecting adole...

    Authors: Heba I. Elnagar, Osama A. Hashem, Hany O. Aboelwafa, Ehab Elhelw and Mohamed L. Elsaie
    Citation: Journal of Ovarian Research 2024 17:21
  21. Bisphenol A (BPA), an endocrine disrupting chemical with weak estrogenic and anti-androgenic activity, is widely present in various environmental media and organisms. It has certain reproductive toxicity and c...

    Authors: Chen Wang, Chaofan He, Shumin Xu, Yuanyuan Gao, Kaixian Wang, Meng Liang and Ke Hu
    Citation: Journal of Ovarian Research 2024 17:20
  22. MUC16 is a heavily glycosylated cell surface mucin cleaved in the tumor microenvironment to shed CA125. CA125 is a serum biomarker expressed by > 95% of non-mucinous advanced stage epithelial ovarian cancers. ...

    Authors: Hsin-Fang Tu, Margaret Wong, Ssu-Hsueh Tseng, Nattha Ingavat, Pola Olczak, Kin Israel Notarte, Chien-fu Hung and Richard B.S. Roden
    Citation: Journal of Ovarian Research 2024 17:19
  23. The ovarian environment of premature ovarian insufficiency (POI) patients exhibits immune dysregulation, which leads to excessive secretion of numerous proinflammatory cytokines that affect ovarian function. A...

    Authors: Bingbing Hu, Xiushuang Zheng and Wei Zhang
    Citation: Journal of Ovarian Research 2024 17:18
  24. Polycystic ovarian syndrome (PCOS) is a genetically complex disorder that involves the interplay of multiple genes and environmental factors. It is characterized by anovulation and irregular menses and is asso...

    Authors: Teodor T. Postolache, Qamar M. Al Tinawi and Claudia Gragnoli
    Citation: Journal of Ovarian Research 2024 17:17
  25. Ovarian cancer (OVCA) is the most lethal gynecologic cancer and chemoresistance remains a major hurdle to successful therapy and survival of OVCA patients. Plasma gelsolin (pGSN) is highly expressed in chemore...

    Authors: Hafiza Bushra Manzoor, Meshach Asare-Werehene, Satyajit Dey Pereira, Kapaettu Satyamoorthy and Benjamin K. Tsang
    Citation: Journal of Ovarian Research 2024 17:15
  26. For women of childbearing age, the biggest problem caused by polycystic ovary syndrome (PCOS) is infertility, which is mainly caused by anovulation, abnormal follicular development, proliferation of small antr...

    Authors: Zichao Huang, Tianyue Xu, Chunling Liu, Honghui Wu, Linglin Weng, Jieyu Cai, Na Liang and Hongshan Ge
    Citation: Journal of Ovarian Research 2024 17:14
  27. Components of the hypothalamic-pituitary axis (HPA) pathway are potential mediators of the genetic risk of polycystic ovarian syndrome (PCOS). Impaired glucocorticoid receptor (NR3C1) expression and function may ...

    Authors: Shumail Syed and Claudia Gragnoli
    Citation: Journal of Ovarian Research 2024 17:13
  28. This study was designed to investigate the pharmacological effects and mechanisms of ErZhiTianGui Decoction (EZTG) for age-related ovarian aging in mice.

    Authors: Jia Zhicheng, Li Yongqian, Wang Peixuan, Yang Kai, Shi Mengyu, Chen Wen, Liang Qihui and Guo Ying
    Citation: Journal of Ovarian Research 2024 17:12
  29. The etiology of polycystic ovary syndrome (PCOS) is complex and variable, and there is no exact cause or good treatment method. Most of the methods of hormones are used to temporarily meet the needs of patient...

    Authors: Shasha Gao, Juan Wang, Lun Wei, Chao Luo, Fei Qian, Le Bo and Caiping Mao
    Citation: Journal of Ovarian Research 2024 17:11
  30. Genetic mosaicism is commonly observed in human blastocysts. Embryos’ morphokinetic feature observed from time-lapse monitoring (TLM) is helpful to predict the embryos’ ploidy status in a non-invasive way. How...

    Authors: Yaoyu Zou, Yilun Sui, Jing Fu, Naidong Ge, Xiaoxi Sun and Yijuan Sun
    Citation: Journal of Ovarian Research 2024 17:10
  31. To investigate the effect of L-carnitine supplementation during the controlled ovarian stimulation (COS) cycle with antagonist protocol in patients with polycystic ovary syndrome (PCOS) diagnosis undergoing IV...

    Authors: Maryam Hafezi, Arezoo Arabipoor, Firouzeh Ghaffari, Samira Vesali, Maryam Zareei and Zahra Hajinaghibali Hessari
    Citation: Journal of Ovarian Research 2024 17:9
  32. Polycystic ovary syndrome (PCOS) is an exceedingly intractable issue affecting female endocrine and reproductive health. However, the etiology and intricate pathological mechanisms of PCOS remain unclear. Nowa...

    Authors: Danni Jiang, Yang Xu, Lin Yang, Pengfei Li, Xiaojuan Han, Qianni Li, Yang Yang and Lan Chao
    Citation: Journal of Ovarian Research 2024 17:7
  33. Polycystic ovarian syndrome (PCOS) is recognized as the most prevalent endocrine disorder among women of reproductive age. While the utilization of assisted reproductive technology (ART) has resulted in favora...

    Authors: Miaomiao Ban, Yifei Sun, Xiaojing Chen, Xiaoqian Zhou, Yiyuan Zhang and Linlin Cui
    Citation: Journal of Ovarian Research 2024 17:6
  34. Existing evidence suggests a relation between cardiovascular dysfunction and diminished ovarian reserve. While it is known that pre-existent cardiovascular dysfunction is also associated with the development o...

    Authors: Bo E. van Bree, Laura M. Jorissen, Désirée A.P.M. Pattinaja, Judith A.P. Bons, Marc E.A. Spaanderman, Olivier Valkenburg and Ron J.T. van Golde
    Citation: Journal of Ovarian Research 2024 17:5
  35. Investigating the utility of serum exosomal markers CA125, HE4, and C5a, both individually and in combination, for distinguishing between benign and malignant ovarian tumors.

    Authors: Huihui Shi, Liya Liu, Xueli Deng, Xiaoyu Xing, Yan Zhang, Yemeli Djouda Rebecca and Liping Han
    Citation: Journal of Ovarian Research 2024 17:4
  36. The intricate interplay of gene expression within ovarian granulosa cells (GCs) is not fully understood. This study aimed to investigate the miRNA regulatory mechanisms of ferroptosis during the process of fol...

    Authors: Gulimire Abudureyimu, Yangsheng Wu, Ying Chen, Liqin Wang, Geng Hao, Jianguo Yu, Jianguo Wang, Jiapeng Lin and Juncheng Huang
    Citation: Journal of Ovarian Research 2024 17:3
  37. The objective of this study was to induce the differentiation of human theca stem cells (hTSCs) into germ cell-like cells (hGCLCs) and assess their developmental progression following in vitro 3D culture with ...

    Authors: Seyedeh Nasim Mirbahari, Christiani A. Amorim, Fatemeh Hassani, Mehdi Totonchi, Mahnaz Haddadi, Mojtaba Rezazadeh valojerdi and Azam Dalman
    Citation: Journal of Ovarian Research 2024 17:2
  38. An unexpected impaired ovarian response pertains to an insufficient reaction to controlled ovarian hyperstimulation. This deficient reaction is identified by a reduced count of mature follicles and retrieved o...

    Authors: Gürkan Uncu, Kiper Aslan, Cihan Cakir, Berrin Avci, Isil Kasapoglu and Carlo Alviggi
    Citation: Journal of Ovarian Research 2024 17:1
  39. Epithelial ovarian cancer (OC) is the fourth leading cause of cancer-related deaths in women, with a 5-year survival rate of 30%-50%. Platinum resistance is the chief culprit for the high recurrence and mortal...

    Authors: Mengjun Zhang, Jialin Wang, Yan Guo, Haodi Yue and Lindong Zhang
    Citation: Journal of Ovarian Research 2023 16:240
  40. Polycystic ovary syndrome (PCOS) is a widespread heterogeneous disease that is in association with genetic, epigenetic, endocrine and environmental factors. Adipose-derived mesenchymal stem cell (ASC) and ASC-...

    Authors: Golnaz Shafiei, Mona Saheli, Sepideh Ganjalikhan-hakemi, Tahereh Haghpanah and Seyed Noureddin Nematollahi-mahani
    Citation: Journal of Ovarian Research 2023 16:238
  41. As a novel prognostic and inflammatory marker, the systemic immune-inflammation index (SII) has come to the foreground in recent years. SII may be used as an indicator reflecting the progressive inflammatory p...

    Authors: Xin Li, Ting Luan, Yi Wei, Juan Zhang, JuanJuan Zhang, Chun Zhao and Xiufeng Ling
    Citation: Journal of Ovarian Research 2023 16:236

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