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  1. Content type: Research

    Metformin influences insulin receptor signaling, which might interfere with the proliferation of ovarian follicular structures and steroidogenesis. We hypothesize that reductions in glucose and insulin levels ...

    Authors: Roberta Rassi Mahamed, Carla Cristina Maganhin, Gisela Rodrigues Silva Sasso, Manuel de Jesus Simões, Maria Candida Pinheiro Baracat, Edmund Chada Baracat and José Maria Soares- Jr

    Citation: Journal of Ovarian Research 2018 11:18

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  2. Content type: Research

    High cyclooxygenase (COX)-2 expression in ovarian tumors has been associated with poor prognosis, but the role of COX-1 expression and its relation to survival is less clear. Here, we evaluated COX expression ...

    Authors: Alicia Beeghly-Fadiel, Andrew J. Wilson, Spencer Keene, Meral El Ramahi, Shu Xu, Lawrence J. Marnett, Oluwole Fadare, Marta A. Crispens and Dineo Khabele

    Citation: Journal of Ovarian Research 2018 11:17

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  3. Content type: Research

    Ovarian cancer is a leading cause of the death from gynecologic malignancies. Hypoxia is closely related to the malignant growth of cells. However, the molecular mechanism of hypoxia-regulated ovarian cancer c...

    Authors: Ke Zhang, Xiangjun Kong, Guangde Feng, Wei Xiang, Long Chen, Fang Yang, Chunyu Cao, Yifei Ding, Hang Chen, Mingxing Chu, Pingqing Wang and Baoyun Zhang

    Citation: Journal of Ovarian Research 2018 11:16

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  4. Content type: Case report

    Pelvic masses are a common gynecologic problem, and majority of them are diagnosed as ovarian tumors finally. Sometimes, it is hard to distinguish the origin of these pelvic masses. The following case is a sol...

    Authors: Wei-Ting Chao, Chia-Hao Liu, Yi-Jen Chen, Hua-Hsi Wu, Chi-Mu Chuang and Peng-Hui Wang

    Citation: Journal of Ovarian Research 2018 11:14

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  5. Content type: Review

    Over these years, more and more sex cord-stromal tumors have been reported. Granulosa cell tumor (GCT) is a rare tumor in ovaries, accounts for 2% to 5% of ovarian cancers. The main different feature of GCTs f...

    Authors: Jiaheng Li, Riqiang Bao, Shiwei Peng and Chunping Zhang

    Citation: Journal of Ovarian Research 2018 11:13

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  6. Content type: Research

    The ST6Gal-I sialyltransferase is upregulated in numerous cancers, and high expression of this enzyme correlates with poor patient prognosis in various malignancies, including ovarian cancer. Through its sialy...

    Authors: Colleen M. Britain, Andrew T. Holdbrooks, Joshua C. Anderson, Christopher D. Willey and Susan L. Bellis

    Citation: Journal of Ovarian Research 2018 11:12

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  7. Content type: Case report

    Struma ovarii is a rare ovarian neoplasm that often appears malignant on conventional imaging. Pseudo-Meigs’ syndrome with ascites, pleural effusion, and elevated serum CA 125 levels is much rarer and leads to...

    Authors: Sayaka Fujiwara, Hideaki Tsuyoshi, Toshiya Nishimura, Nozomu Takahashi and Yoshio Yoshida

    Citation: Journal of Ovarian Research 2018 11:11

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  8. Content type: Research

    Cancer is widely believed to result from chronic inflammation, and red cell distribution width (RDW) and mean platelet volume (MPV) are considered as inflammatory markers for cancer. We investigated the values...

    Authors: Yuan-yuan Qin, Yang-yang Wu, Xiao-ying Xian, Jin-qiu Qin, Zhan-feng Lai, Lin Liao and Fa-quan Lin

    Citation: Journal of Ovarian Research 2018 11:10

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  9. Content type: Research

    Toll-like receptors (TLRs) are transmembrane proteins expressed on the surface of ovarian cancer (OC) and immune cells. Identifying the specific roles of the TLR-mediated signaling pathways in OC cells is impo...

    Authors: Luiz Gustavo de Almeida Chuffa, Grazielle de Moura Ferreira, Luiz Antonio Lupi, Iseu da Silva Nunes and Wagner José Fávaro

    Citation: Journal of Ovarian Research 2018 11:8

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  10. Content type: Research

    The polycystic ovary syndrome (PCOS) is a common metabolic and endocrine disorder with pathological mechanisms remain unclear. The following study investigates the ovarian hyperfibrosis forming via transformin...

    Authors: Daojuan Wang, Wenqing Wang, Qiao Liang, Xuan He, Yanjie Xia, Shanmei Shen, Hongwei Wang, Qian Gao and Yong Wang

    Citation: Journal of Ovarian Research 2018 11:6

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  11. Content type: Research

    Serous borderline tumor (SBT) of the micropapillary type (SBT-MP) became one of the major pathological SBT diagnoses in addition to typical SBT, and was also defined as “non-invasive” low-gradeserous carcinoma...

    Authors: Go Nakai, Takashi Yamada, Kazuhiro Yamamoto, Yoshinobu Hirose, Masahide Ohmichi and Yoshifumi Narumi

    Citation: Journal of Ovarian Research 2018 11:7

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  12. Content type: Research

    To evaluate the performance of computed tomography (CT) as a diagnostic aid to differentiate between ruptured ovarian corpus luteal cyst (ROCLC) and ruptured ectopic pregnancy with hemorrhage (REPWH).

    Authors: Xiaohong Liu, Litao Song, Jian Wang, Qin Liu, Yingna Liu and Xin Zhang

    Citation: Journal of Ovarian Research 2018 11:5

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  13. Content type: Research

    Stem cells in the ovary comprise of two distinct populations including very small embryonic-like stem cells (VSELs) and slightly bigger progenitors termed ovarian stem cells (OSCs). They are lodged in ovary su...

    Authors: Hiren Patel, Deepa Bhartiya and Seema Parte

    Citation: Journal of Ovarian Research 2018 11:3

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  14. Content type: Research

    Autotransplantation of cryopreserved ovarian cortex can be associated with a risk of cancer cell reseeding. This issue could be eliminated by grafting isolated preantral follicles. Collagenase NB6 is an enzyme...

    Authors: Elodie Mouloungui, Tristan Zver, Christophe Roux and Clotilde Amiot

    Citation: Journal of Ovarian Research 2018 11:4

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  15. Content type: Research

    MMP and TIMP play an important role in the degradation of extracellular matrix components which are essential for tumor growth, invasion and metastasis. Aim of this research was to assess MMP3 and TIMP3 as pro...

    Authors: Aneta Cymbaluk-Płoska, Anita Chudecka-Głaz, Ewa Pius-Sadowska, Bogusław Machaliński, Janusz Menkiszak and Agnieszka Sompolska-Rzechuła

    Citation: Journal of Ovarian Research 2018 11:1

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  16. Content type: Research

    Improvements in oocyte cryopreservation techniques and establishment of cryopreserved donor oocyte banks have led to improved access to and lower cost of donor oocytes, upending the traditional practice of fre...

    Authors: Vitaly A. Kushnir, Sarah K. Darmon, David H. Barad and Norbert Gleicher

    Citation: Journal of Ovarian Research 2018 11:2

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  17. Content type: Research

    Food restriction during pregnancy can influence the health of the offspring during the adulthood. The aim of the present study was to examine the effect of maternal food restriction (MFR) on the reproductive p...

    Authors: Abdel Halim Harrath, Abdulkarem Alrezaki, Lamjed Mansour, Saleh H. Alwasel and Stefano Palomba

    Citation: Journal of Ovarian Research 2017 10:77

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  18. Content type: Research

    TEK signaling plays a very important role in folliculogenesis. It activates Ras/ERK/MYC, PI3K/AKT/mTORC1 and ovarian steroidogenesis activation pathways. These are the main pathways for cell growth, differenti...

    Authors: Abolfazl Bahrami, Seyed Reza Miraie-Ashtiani, Mostafa Sadeghi, Ali Najafi and Reza Ranjbar

    Citation: Journal of Ovarian Research 2017 10:76

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  19. Content type: Review

    Limited understanding of ovarian cancer (OC) genome portrait has hindered the therapeutic advances. The serial monitoring of tumor genotypes is becoming increasingly attainable with circulating cell-free DNA (...

    Authors: Xianliang Cheng, Lei Zhang, Yajuan Chen and Chen Qing

    Citation: Journal of Ovarian Research 2017 10:75

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  20. Content type: Research

    Supplementation of bovine oocyte-cumulus complexes during in vitro maturation (IVM) with 1 μM of docosahexaenoic acid (DHA), C22:6 n-3 polyunsaturated fatty acid, was reported to improve in vitro embryo develo...

    Authors: Sebastien Elis, Mouhamad Oseikria, Anais Vitorino Carvalho, Priscila Silvana Bertevello, Emilie Corbin, Ana-Paula Teixeira-Gomes, Jérôme Lecardonnel, Catherine Archilla, Véronique Duranthon, Valérie Labas and Svetlana Uzbekova

    Citation: Journal of Ovarian Research 2017 10:74

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  21. Content type: Review

    Exosomes are nanoparticles(40-100 nm) secreted by most cells in the body, which can be isolated from several types of extracellular fluids. It has been shown that exosomes play a key role in intercellular comm...

    Authors: Lin Cheng, Shuying Wu, Kun Zhang, Yun’an Qing and Tianmin Xu

    Citation: Journal of Ovarian Research 2017 10:73

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  22. Content type: Research

    In order to validate if the test result of the Chemotherapy Resistance Test (CTR-Test) is able to predict the resistances or sensitivities of tumors in ovarian cancer patients to drugs, the CTR-Test result and...

    Authors: Frank Christian Kischkel, Carina Meyer, Julia Eich, Mani Nassir, Monika Mentze, Ioana Braicu, Annette Kopp-Schneider and Jalid Sehouli

    Citation: Journal of Ovarian Research 2017 10:72

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  23. Content type: Research

    Ovarian tissue cryopreservation followed by transplantation after cancer remission is the most commonly applied fertility restoration approach in very young girls and women who require immediate cancer therapy...

    Authors: Maria Costanza Chiti, Marie-Madeleine Dolmans, Maria Hobeika, Alice Cernogoraz, Jacques Donnez and Christiani Andrade Amorim

    Citation: Journal of Ovarian Research 2017 10:71

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  24. Content type: Research

    There is no consensus on the exact parameters that define the LH surge for natural cycle frozen-thawed embryo transfers (NC-FET). Accurately determining the LH surge would affect the timing, and subsequently t...

    Authors: Mohamad Irani, Alex Robles, Vinay Gunnala, David Reichman and Zev Rosenwaks

    Citation: Journal of Ovarian Research 2017 10:70

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  25. Content type: Research

    Metastasis is the major cause of morbidity and mortality in patients with epithelial ovarian cancer (EOC), however the mechanisms that underline this process are poorly understood. Collagen triple helix repeat...

    Authors: Biying Guo, Huan Yan, Luying Li, Kemin Yin, Fang Ji and Shu Zhang

    Citation: Journal of Ovarian Research 2017 10:69

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  26. Content type: Research

    Luteinizing hormone (LH) regulation of the ligand, natriuretic peptide precursor type C, and its receptor, natriuretic peptide receptor 2 (NPR2), is critical for oocyte maturation; however, the mechanism is no...

    Authors: Wenchao Sun, Chang Liu, Ying Feng, Guangchao Zhuo, Wenjing Zhou, Xiaoyang Fei and Zhifen Zhang

    Citation: Journal of Ovarian Research 2017 10:68

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  27. Content type: Research

    Clinico-pathological characteristics and possible prognostic factors among women with epithelial ovarian carcinoma (EOC) with or without concurrent endometriosis were explored.

    Authors: Tong Ren, Shu Wang, Jian Sun, Ji-Min Qu, Yang Xiang, Keng Shen and Jing He Lang

    Citation: Journal of Ovarian Research 2017 10:67

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  28. Content type: Research

    Elevated hyaluronan-mediated motility receptor (RHAMM) has been reported to contribute to disease progression, aggressive phenotype and poor prognosis in multiple cancer types, however, RHAMM’s role in ovarian...

    Authors: Stephanie T. Buttermore, Mitchel S. Hoffman, Ambuj Kumar, Anne Champeaux, Santo V. Nicosia and Patricia A. Kruk

    Citation: Journal of Ovarian Research 2017 10:66

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  29. Content type: Research

    To investigate dynamic contrast enhanced magnetic resonance imaging (DCE-MRI) for assessing histopathological and molecular biological features in induced rat epithelial ovarian carcinomas (EOCs).

    Authors: Su Juan Yuan, Tian Kui Qiao, Jin Wei Qiang, Song Qi Cai and Ruo Kun Li

    Citation: Journal of Ovarian Research 2017 10:65

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  30. Content type: Review

    Ovarian cancer (OC) is the most lethal gynecological malignancy, which disproportionately affects African American (AA) women. Lack of awareness and socioeconomic factors are considered important players in OC...

    Authors: Sanjeev K. Srivastava, Aamir Ahmad, Orlandric Miree, Girijesh Kumar Patel, Seema Singh, Rodney P. Rocconi and Ajay P. Singh

    Citation: Journal of Ovarian Research 2017 10:58

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  31. Content type: Research

    New data suggests that endothelial cells (ECs) elaborate essential “angiocrine factors”. The aim of this study is to investigate the role of activated ovarian endothelial cells in early in-vitro follicular dev...

    Authors: Alon Kedem, Anate Aelion-Brauer, Peipei Guo, Duancheng Wen, Bi-Sen Ding, Raphael Lis, Du Cheng, Vladislav M. Sandler, Shahin Rafii and Zev Rosenwaks

    Citation: Journal of Ovarian Research 2017 10:64

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  32. Content type: Research

    Resveratrol (3,5,4′-trihydroxy-trans-stilbene) is a natural antioxidant polyphenol able to exert a wide range of biological effect on several tissues. Despite its important beneficial properties, it has a low ...

    Authors: Francesca Uberti, Vera Morsanuto, Silvio Aprile, Sabrina Ghirlanda, Ian Stoppa, Andrea Cochis, Giorgio Grosa, Lia Rimondini and Claudio Molinari

    Citation: Journal of Ovarian Research 2017 10:61

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  33. Content type: Research

    PCOs is a heterogeneous disorder with anovulation/oligo ovulation usually taken as oligo menorrhoea or amenorrhoea, hyperandrogenemia, hirsutism, acne, androgen alopecia and polycystic ovaries as the key diagn...

    Authors: Asad Ullah, Sarwat Jahan, Suhail Razak, Madeeha Pirzada, Hizb Ullah, Ali Almajwal, Naveed Rauf and Tayyaba Afsar

    Citation: Journal of Ovarian Research 2017 10:62

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  34. Content type: Research

    Upregulation of Cyclin dependent kinase 1 (CDK1) protein is closely related with the prognosis of several malignant tumors. Chk1-CDC25C-CDK1 signaling and P53-P21WAF1-CDK1 signaling pathways are closely relate...

    Authors: Ruitao Zhang, Huirong Shi, Fang Ren, Minghui Zhang, Pengcheng Ji, Wenwen Wang and Chuanna Liu

    Citation: Journal of Ovarian Research 2017 10:60

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  35. Content type: Research

    The purpose of this study is to examine whether racial disparities in epithelial ovarian cancer stage at diagnosis and survival may be explained by geographic availability of healthcare resources among Blacks ...

    Authors: Swati Sakhuja, Huifeng Yun, Maria Pisu and Tomi Akinyemiju

    Citation: Journal of Ovarian Research 2017 10:57

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  36. Content type: Research

    Primordial follicular depletion has thought to be a common adverse effect of chemotherapy especially for female of reproductive age. The study aimed to evaluate the protective effect of rapamycin on the primor...

    Authors: Linyan Zhou, Yanqiu Xie, Song Li, Yihua Liang, Qi Qiu, Haiyan Lin and Qingxue Zhang

    Citation: Journal of Ovarian Research 2017 10:56

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  37. Content type: Research

    There is no universal screening method for discrimination between benign and malignant adnexal masses yet. Various authors have tried tumor markers, imaging studies, cytology but no one yet is a definite metho...

    Authors: Santosh Kumar Dora, Atal Bihari Dandapat, Benudhar Pande and Jatindra Prasad Hota

    Citation: Journal of Ovarian Research 2017 10:55

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  38. Content type: Research

    Small leucine-rich proteoglycans (SLRPs) play an important role in tissue homeostasis and cell proliferation since these proteoglycans sequester multiple growth factors. However, the content of SLRPs in the en...

    Authors: Ricardo Santos Simões, José Maria Soares-Jr, Manuel J. Simões, Helena B. Nader, Maria Cândida P. Baracat, Gustavo Arantes R. Maciel, Paulo C. Serafini, Ricardo Azziz and Edmund C. Baracat

    Citation: Journal of Ovarian Research 2017 10:54

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  39. Content type: Research

    Ovarian carcinoma is highly dependent on the ubiquitin proteasome system (UPS), but its clinical response to treatment with the proteasome inhibitor bortezomib has been disappointing. This has driven explorati...

    Authors: Rosie T. Jiang, Anna Yemelyanova, Deyin Xing, Ravi K. Anchoori, Jun Hamazaki, Shigeo Murata, Jeffrey D. Seidman, Tian-Li Wang and Richard B. S. Roden

    Citation: Journal of Ovarian Research 2017 10:53

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  40. Content type: Research

    To retrospectively investigate reproductive outcomes after fertility-sparing surgery and postoperative adjuvant chemotherapy in malignant ovarian germ cell tumors (MOGCT) and sex cord-stromal tumors (SCST).

    Authors: Ning Zhang, Ruifang Chen, Keqin Hua and Ying Zhang

    Citation: Journal of Ovarian Research 2017 10:52

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  41. Content type: Research

    Discoidin Domain Receptor 1 (DDR1) belongs to the family of collagen receptor tyrosine kinases that confers the progression of various cancers. Aberrant expression of DDR1 was detected in several human cancers...

    Authors: Yuao Deng, Fang Zhao, Liu Hui, Xiuyun Li, Danyu Zhang, Wang Lin, Zhiqiang Chen and Yingxia Ning

    Citation: Journal of Ovarian Research 2017 10:50

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  42. Content type: Research

    R-spondin2 (Rspo2) is a secreted agonist of the canonical Wnt/β-catenin signaling pathway. Rspo2 plays a key role in development of limbs, lungs and hair follicles, and more recently during ovarian follicle de...

    Authors: Justine Bouilly, Isabelle Beau, Sara Barraud, Valérie Bernard, Brigitte Delemer, Jacques Young and Nadine Binart

    Citation: Journal of Ovarian Research 2017 10:51

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  43. Content type: Research

    Ovarian cancer is one of the three leading gynecological malignancies, characterized by insidious growth, highly frequent metastasis, and quick development of drug resistance. As a result, this disease has low...

    Authors: Huidi Liu, Jianrui Liu, Siwen Wang, Zheng Zeng, Ting Li, Yongfang Liu, Emilio Mastriani, Qing-Hai Li, Hong-Xia Bao, Yu-Jie Zhou, Xiaoyu Wang, Sijing Hu, Shan Gao, Yingying Qi, Zhihang Shen, Hongyue Wang…

    Citation: Journal of Ovarian Research 2017 10:49

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  44. Content type: Research

    An upward trending incidence in cervical adenocarcinoma (ADC) has been reported in many countries. Because non-squamous histology has been associated with increased risk of ovarian metastases (OM), bilateral o...

    Authors: Jiansong Zhou, Yuanyuan Chen, Ping Zhang and Hanmei Lou

    Citation: Journal of Ovarian Research 2017 10:48

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  45. Content type: Case report

    Choriocarcinoma of the ovary is rare. This tumor can arise from gestational tissue or pure germ cells of the ovary, the former results in gestational choriocarcinoma. The clinical characteristics and histology...

    Authors: Nan Jia, Yan Chen, Xiang Tao, Enzhi Ou, Xin Lu and Weiwei Feng

    Citation: Journal of Ovarian Research 2017 10:46

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