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  1. Content type: Research

    A previous study showed that dopamine (DA), which is contained in follicular fluid (FF) from IVF patients, strongly increased the production of reactive oxygen species (ROS) by cultured human granulosa cells (...

    Authors: J. Blohberger, T. Buck, D. Berg, U. Berg, L. Kunz and A. Mayerhofer

    Citation: Journal of Ovarian Research 2016 9:62

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  2. Content type: Research

    The aim of this study is to evaluate a new tumour marker, HE4, and to compare it with CA125 in predicting optimal cytoreduction and response to chemotherapy. Thirty patients with advanced epithelial ovarian ca...

    Authors: Aurélie Pelissier, Aurélie Roulot, Béatrice Guéry, Claire Bonneau, Dominique Bellet and Roman Rouzier

    Citation: Journal of Ovarian Research 2016 9:61

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  3. Content type: Research

    Because higher survival of follicles during the freezing/thawing procedure improves the quality of cryopreserved tissue reimplanted after oncological therapies, defining an optimal method for human ovarian tis...

    Authors: D. Scheiner, G. Bracone, P. Imesch, D. Fink, J. Hehl and B. Imthurn

    Citation: Journal of Ovarian Research 2016 9:59

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  4. Content type: Research

    The reduced expression of the Adenomatous polyposis coli (APC) gene, a tumor suppressor gene, through promoter hypermethylation has been reported to play a key role in the carcinogenesis. However, the correlation...

    Authors: Chunyan Shen, Qifang Sheng, Xiaojie Zhang, Yuling Fu and Kemiao Zhu

    Citation: Journal of Ovarian Research 2016 9:60

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  5. Content type: Research

    Pre-clinical studies have demonstrated that natural and synthetic histone deacetylase (HDAC) inhibitors can impede the in vitro and in vivo growth of cell lines from a variety of gynecologic and other malignan...

    Authors: Leslie A. Garrett, Whitfield B. Growdon, Bo R. Rueda and Rosemary Foster

    Citation: Journal of Ovarian Research 2016 9:58

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  6. Content type: Research

    Ovarian cancer has the highest mortality rate of the three main malignant tumors of the female reproductive system, with a 5-year overall survival (OS) of only 20–30 %. Approximately 70 % of patients relapse w...

    Authors: Zhi-jun Yang, Bing-bing Zhao and Li Li

    Citation: Journal of Ovarian Research 2016 9:57

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  7. Content type: Research

    Previous studies have shown that circadian genes might be involved in the development of polycystic ovarian syndrome (PCOS). Hyperandrogenism is a hallmark feature of PCOS. However, the effect of hyperandrogen...

    Authors: Minghui Chen, Yanwen Xu, Benyu Miao, Hui Zhao, Lu Luo, Huijuan Shi and Canquan Zhou

    Citation: Journal of Ovarian Research 2016 9:56

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  8. Content type: Research

    Experience on sentinel node mapping in ovarian tumors is very limited. We evaluated the sentinel node concept in ovarian tumors using intra-operativeTc-99m-Phytate injection and lymphoscintigraphy imaging.

    Authors: Malihe Hassanzadeh, Elham Hosseini Farahabadi, Zohreh Yousefi, Sima Kadkhodayan, Leili Zarifmahmoudi and Ramin Sadeghi

    Citation: Journal of Ovarian Research 2016 9:55

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  9. Content type: Case report

    Resistant ovary syndrome (ROS) is a rare endocrine disorder characterized with hypergonadotrophic hypogonadism. Infertility is a common complaint of woman presenting with ROS, and little progress has been made...

    Authors: Yu Li, Ping Pan, Ping Yuan, Qi Qiu and Dongzi Yang

    Citation: Journal of Ovarian Research 2016 9:54

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  10. Content type: Research

    To investigate the expression of MMP-14 and CD44 as well as epithelial-to-mesenchymal transition(EMT)-like changes in ovarian cancer and to determine correlations with clinical outcome.

    Authors: Maria Caroline Vos, Eva Hollemans, Nicole Ezendam, Harry Feijen, Dorry Boll, Brenda Pijlman, Hans van der Putten, Paul Klinkhamer, Toin H. van Kuppevelt, Anneke A. M. van der Wurff and Leon F. A. G. Massuger

    Citation: Journal of Ovarian Research 2016 9:53

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  11. Content type: Research

    As we have previously reported, small cell carcinoma of the ovary (SCCO) is a rare, aggressive form of ovarian cancer associated with poor outcomes. In an effort to identify new treatment options, we utilized ...

    Authors: George Yaghmour, Philippe Prouet, Eric Wiedower, Omer Hassan Jamy, Rebecca Feldman, Jason C Chandler, Manjari Pandey and Mike G Martin

    Citation: Journal of Ovarian Research 2016 9:52

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  12. Content type: Research

    Ovarian tissue cryopreservation is an emerging technique, also addressed to very young cancer patients, for whom it is not possible to perform an ovarian stimulation for oocytes freezing, before gonadotoxic tr...

    Authors: Raffaella Fabbri, Maria Macciocca, Rossella Vicenti, Gianandrea Pasquinelli, Giacomo Caprara, Sabrina Valente, Renato Seracchioli and Roberto Paradisi

    Citation: Journal of Ovarian Research 2016 9:50

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  13. Content type: Research

    There are various parameters to analyze obesity, however, no standard reference to predict, screen or diagnose PCOS with various obesity parameters has been established, and the accuracy of these parameters st...

    Authors: Pan Dou, Huiyan Ju, Jing Shang, Xueying Li, Qing Xue, Yang Xu and Xiaohui Guo

    Citation: Journal of Ovarian Research 2016 9:51

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  14. Content type: Case report

    The aims of this report were to describe a case of ovarian adenosquamous carcinoma and to systematically review the pertinent literature.

    Authors: Tadahiro Shoji, Eriko Takatori, Kazuyuki Murakami, Yoshitaka Kaido, Satoshi Takeuchi, Akihiko Kikuchi and Toru Sugiyama

    Citation: Journal of Ovarian Research 2016 9:48

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  15. Content type: Research

    Improved cancer therapeutics and enhanced cancer survivorship have emphasized the severe long-term side effects of chemotherapy. Specifically, studies have linked many chemotherapy agents with primary ovarian ...

    Authors: Matthew R. Zanotelli, Joseph D. Henningsen, Patrick M. Hopkins, Aaron P. Dederich, Tessa Herman, Tracy J. Puccinelli and Sana M. Salih

    Citation: Journal of Ovarian Research 2016 9:47

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  16. Content type: Case report

    Sertoli - Leydig cell tumors (SLCTs) are sex-cord stromal tumors that account less than 0.5 % of primary ovarian neoplasms. They are mostly benign and occur in reproductive age women. Variants with heterologou...

    Authors: T. Burnik Papler, S. Frković Grazio and B. Kobal

    Citation: Journal of Ovarian Research 2016 9:46

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  17. Content type: Research

    Oviducts participate in fertilization and early embryo development, and they are influenced by systemic and local circulation. Local functional interplay between ovary, oviduct and uterus is important, as dedu...

    Authors: Rebeca López-Úbeda, Marta Muñoz, Luis Vieira, Ronald H. F. Hunter, Pilar Coy and Sebastian Canovas

    Citation: Journal of Ovarian Research 2016 9:44

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  18. Content type: Research

    The aim of this study was to evaluate HE4, CA125 and ROMA in the preoperative differentiation benign ovarian diseases from epithelial ovarian cancer depending on the menopausal status.

    Authors: Katarzyna M. Terlikowska, Bozena Dobrzycka, Anna M. Witkowska, Beata Mackowiak-Matejczyk, Tomasz Kamil Sledziewski, Maciej Kinalski and Slawomir J. Terlikowski

    Citation: Journal of Ovarian Research 2016 9:43

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  19. Content type: Research

    Serum levels of CA125 measured before any treatment have been evaluated in epithelial ovarian cancer (EOC) as a predictor of patient survival; however, results in survival index are controversial, as CA125 lev...

    Authors: Flavia Morales-Vásquez, Enrique Pedernera, Jesús Reynaga-Obregón, Horacio Noé López-Basave, María José Gómora, Elisa Carlón, Sandra Cárdenas, Raúl Silva-Ayala, Miguel Almaraz and Carmen Méndez

    Citation: Journal of Ovarian Research 2016 9:41

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  20. Content type: Research

    Prenatal testosterone (T) excess from days 30-90 of gestation disrupts gonadotropin surge and ovarian follicular dynamics and induces insulin resistance and functional hyperandrogenism in sheep. T treatment fr...

    Authors: A Veiga-Lopez, J Moeller, D. H. Abbott and V Padmanabhan

    Citation: Journal of Ovarian Research 2016 9:39

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  21. Content type: Research

    A major hurdle incurrent to the human clinical application of conditionally replicative adenovirus (CRAd)-based virotherapy agents is their limited therapeutic efficacy. In this study we evaluated whether armi...

    Authors: Ahmad Mohammad Ashshi, Adel Galal El-Shemi, Igor P. Dmitriev, Elena A. Kashentseva and David T. Curiel

    Citation: Journal of Ovarian Research 2016 9:38

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  22. Content type: Brief communication

    Normal development of reproductive organs is crucial for successful reproduction. In mice the early ovarian developmental process occurs during the embryonic and postnatal period and is regulated through a ser...

    Authors: Hannah M. Wear, Matthew J. McPike and Karen H. Watanabe

    Citation: Journal of Ovarian Research 2016 9:36

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  23. Content type: Research

    Ovarian endometriomas affect a substantial proportion of women of reproductive age who may have a potential risk of diminished ovarian reserve (DOR) after ovarian cystectomy. Here, we investigated the risk fac...

    Authors: Rie Ozaki, Jun Kumakiri, Andrea Tinelli, Grigoris F. Grimbizis, Mari Kitade and Satoru Takeda

    Citation: Journal of Ovarian Research 2016 9:37

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  24. Content type: Research

    Recently, vitamin D3 (1alpha, 25-dihydroxyvitamin D) has shown its capability to take part in many extraskeletal functions and its serum levels have been related to patient survival rate and malignancy of many ty...

    Authors: Francesca Uberti, Vera Morsanuto, Debora Lattuada, Barbara Colciaghi, Andrea Cochis, Alessandro Bulfoni, Paola Colombo, Giorgio Bolis and Claudio Molinari

    Citation: Journal of Ovarian Research 2016 9:34

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  25. Content type: Review

    Melatonin is an indolamine produced by the pineal gland and it can exert a potent antioxidant effect. Its free radical scavenger properties have been used to advantage in different organ transplants in animal ...

    Authors: M. E. Shiroma, N. M. Botelho, L. L. Damous, E. C. Baracat and J. M. Soares-Jr

    Citation: Journal of Ovarian Research 2016 9:33

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  26. Content type: Research

    Cell lines are very useful for both clinical and basic research. The establishment of ovarian, malignant tumor cell lines with aggressive histology is especially important. We describe the establishment and ch...

    Authors: Takashi Yamada, Kimiaki Hattori, Hidetoshi Satomi, Tadashi Okazaki, Hiroshi Mori and Yoshinobu Hirose

    Citation: Journal of Ovarian Research 2016 9:32

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  27. Content type: Brief communication

    High-Grade Serous Ovarian Carcinoma (HGSOC) is the predominant histotype of epithelial ovarian cancer (EOC), characterized by advanced stage at diagnosis, frequent TP53 mutation, rapid progression, and high re...

    Authors: Chiara Mignogna, Nicoletta Staropoli, Cirino Botta, Carmela De Marco, Antonia Rizzuto, Michele Morelli, Annalisa Di Cello, Renato Franco, Caterina Camastra, Ivan Presta, Natalia Malara, Angela Salvino, Pierfrancesco Tassone, Pierosandro Tagliaferri, Tullio Barni, Giuseppe Donato…

    Citation: Journal of Ovarian Research 2016 9:31

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  28. Content type: Research

    Chemotherapy resistance presents a difficult challenge in treating epithelial ovarian cancer patients, particularly when tumors exhibit resistance to multiple chemotherapeutic agents. A few studies have shown ...

    Authors: J. R. Ribeiro, C. Schorl, N. Yano, N. Romano, K. K. Kim, R. K. Singh and R. G. Moore

    Citation: Journal of Ovarian Research 2016 9:28

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  29. Content type: Review

    The standard front-line therapy for epithelial ovarian cancer (EOC) is combination of debulking surgery and platinum-based chemotherapy. Nevertheless, the majority of patients experience disease recurrence. Al...

    Authors: Gloria Mittica, Sonia Capellero, Sofia Genta, Celeste Cagnazzo, Massimo Aglietta, Dario Sangiolo and Giorgio Valabrega

    Citation: Journal of Ovarian Research 2016 9:30

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  30. Content type: Research

    The aim of this study was to compare the efficacy of antagonist rescue protocol (replacing GnRH agonist with GnRH antagonist and reducing the dose of gonadotropins) combined with cabergoline versus cabergoline...

    Authors: Usama M. Fouda, Ahmed M. Sayed, Hesham S. Elshaer, Bahaa Eldin M. Hammad, Mona M. Shaban, Khaled A. Elsetohy and Mohamed A. Youssef

    Citation: Journal of Ovarian Research 2016 9:29

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  31. Content type: Research

    Mutation in the tumor suppressor gene TP53 is an early event in the development of high-grade serous (HGS) ovarian cancer and is identified in more than 96 % of HGS cancer patients. APR-246 (PRIMA-1MET) is the fi...

    Authors: Åsa Fransson, Daria Glaessgen, Jessica Alfredsson, Klas G. Wiman, Svetlana Bajalica-Lagercrantz and Nina Mohell

    Citation: Journal of Ovarian Research 2016 9:27

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  32. Content type: Research

    Deficiency in Vitamin D3 (cholecalciferol) may predispose to some malignancies, including gonadal tumors and in experimental models vitamin D3 has been proven to inhibit the growth of cancer cells. To learn mo...

    Authors: Ahmed Abdelbaset-Ismail, Daniel Pedziwiatr, Ewa Suszyńska, Sylwia Sluczanowska-Glabowska, Gabriela Schneider, Sham S. Kakar and Mariusz Z. Ratajczak

    Citation: Journal of Ovarian Research 2016 9:26

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  33. Content type: Research

    BH3 mimetics are a class of drugs that antagonize the Bcl-2 family of apoptosis inhibitors. We have previously shown that these compounds can potentiate the activity of carboplatin against several ovarian canc...

    Authors: Mohammed Najim Abed, Marwan Ibrahim Abdullah and Alan Richardson

    Citation: Journal of Ovarian Research 2016 9:25

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  34. Content type: Research

    Recent findings have revealed that the female gonad may have regenerative activity with having germ line stem cells in juveniles and adults. Application of these germ line stem cells could be an alternative th...

    Authors: Yeon-Mi Lee, Tae-Ho Kim, Jeong-Hyeon Lee, Won-Jae Lee, Ryoung-Hoon Jeon, Si-Jung Jang, Sun-A Ock, Sung-Lim Lee, Bong-Wook Park and Gyu-Jin Rho

    Citation: Journal of Ovarian Research 2016 9:24

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  35. Content type: Research

    The down-regulation of E-cadherin gene (CDH1) expression has been regarded as an important event in cancer invasion and metastasis. However, the association between CDH1 promoter methylation and ovarian cancer re...

    Authors: Qiang Wang, Bing Wang, Yun-mei Zhang and Wei Wang

    Citation: Journal of Ovarian Research 2016 9:23

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  36. Content type: Research

    To evaluate the effects of an ovulation triggering agent, human chorionic gonadotropin (hCG), versus a gonadotropin-releasing hormone agonist (GnRHa) on early embryo development in vitro using a time-lapse system...

    Authors: Ali Sami Gurbuz, Funda Gode, Mehmet Sukru Uzman, Betul Ince, Melek Kaya, Necati Ozcimen, Emel Ebru Ozcimen and Ali Acar

    Citation: Journal of Ovarian Research 2016 9:22

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  37. Content type: Research

    The critical role of the immune system in controlling cancer progression has become evident and immune modulatory therapy is now approved for clinical use. However, while the majority of studies on the inflamm...

    Authors: Sebastian Lundgren, Jonna Berntsson, Björn Nodin, Patrick Micke and Karin Jirström

    Citation: Journal of Ovarian Research 2016 9:21

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  38. Content type: Research

    Ovarian cancer (OVC) is the deadliest of all gynecologic cancers, primarily as a consequence of asymptomatic progression. The complex nature of OVC creates challenges for early detection, and there is a lack o...

    Authors: Ayala Tamir, Anju Gangadharan, Sakshi Balwani, Takemi Tanaka, Ushma Patel, Ahmed Hassan, Stephanie Benke, Agnieszka Agas, Joseph D’Agostino, Dayoung Shin, Sunghoon Yoon, Andre Goy, Andrew Pecora and K. Stephen Suh

    Citation: Journal of Ovarian Research 2016 9:20

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  39. Content type: Research

    Breast cancer associated (BRCA) genes are critical for DNA repair. Mutations in BRCA1 and BRCA2 (BRCAm) result in loss of these repair mechanisms and potential carcinogenesis. Germline BRCAm are common in ovarian...

    Authors: Sudhir K. Unni, Marisa B. Schauerhamer, Rishi Deka, Jerzy E. Tyczynski, Ancilla W. Fernandes, Vanessa Stevens, Diana I. Brixner and David D. Stenehjem

    Citation: Journal of Ovarian Research 2016 9:18

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  40. Content type: Research

    Amplified centrosomes are widely recognized as a hallmark of cancer. Although supernumerary centrosomes would be expected to compromise cell viability by yielding multipolar spindles that results in death-indu...

    Authors: Karuna Mittal, Da Hoon Choi, Sergey Klimov, Shrikant Pawar, Ramneet Kaur, Anirban K. Mitra, Meenakshi V. Gupta, Ralph Sams, Guilherme Cantuaria, Padmashree C. G. Rida and Ritu Aneja

    Citation: Journal of Ovarian Research 2016 9:17

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  41. Content type: Research

    Fertility-sparing surgery for patients with borderline ovarian tumors (BOTs) is still controversial. This study aimed to evaluate the oncological safety and fertility benefits in conservative surgery,as well a...

    Authors: Rui-fang Chen, Jun Li, Ting-ting Zhu, Hai-lin Yu and Xin Lu

    Citation: Journal of Ovarian Research 2016 9:16

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  42. Content type: Research

    Ovarian autotransplantation has shown increasing promise as a clinical method for the preservation of fertility and hormonal function. However, information regarding the success rate of this type of transplant...

    Authors: Lia Cruz V. C. Damásio, José Maria Soares-Júnior, Jairo Iavelberg, Gustavo A. R. Maciel, Manuel de Jesus Simões, Ricardo dos Santos Simões, Eduardo Vieira da Motta, Maria Cândida Pinheiro Baracat and Edmund C. Baracat

    Citation: Journal of Ovarian Research 2016 9:14

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  43. Content type: Research

    The ovulatory LH surge rapidly alters the expression of steroidogenesis-related genes such as steroidogenic acute regulatory protein (StAR) in granulosa cells (GCs) undergoing luteinization. We recently reported ...

    Authors: Ryo Maekawa, Lifa Lee, Maki Okada, Hiromi Asada, Masahiro Shinagawa, Isao Tamura, Shun Sato, Hiroshi Tamura and Norihiro Sugino

    Citation: Journal of Ovarian Research 2016 9:15

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